Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes

RATIONALE The efficiency of Sirtuin1, a major target for the treatment of various metabolic disorders such as inflammation and type 2 diabetes mellitus, can be modulated via low molecular mass SIRT1 activators (e.g. resveratrol, SRT1720, and SRT2104).The administration of such compounds results in i...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2013-01, Vol.27 (1), p.35-50
Hauptverfasser:	Höppner, Sebastian, Schänzer, Wilhelm, Thevis, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Chromatography, Liquid - methods Doping in Sports - prevention & control Drug Discovery - methods Enzyme Activators - blood Enzyme Activators - chemistry Enzyme Activators - pharmacology Heterocyclic Compounds, 2-Ring - blood Heterocyclic Compounds, 2-Ring - chemistry Heterocyclic Compounds, 2-Ring - pharmacology Heterocyclic Compounds, 4 or More Rings - blood Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Limit of Detection Mass spectrometry Metabolic disorders Models, Chemical Plasma Reproducibility of Results Sirtuin 1 - metabolism Tandem Mass Spectrometry - methods
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