Identification and classification of conopeptides using profile Hidden Markov Models

Conopeptides are small toxins produced by predatory marine snails of the genus Conus. They are studied with increasing intensity due to their potential in neurosciences and pharmacology. The number of existing conopeptides is estimated to be 1 million, but only about 1000 have been described to date...

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Veröffentlicht in:	Biochimica et biophysica acta 2012-03, Vol.1824 (3), p.488-492
Hauptverfasser:	Laht, Silja, Koua, Dominique, Kaplinski, Lauris, Lisacek, Frédérique, Stöcklin, Reto, Remm, Maido
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Conopeptide Conopeptide superfamilies Conotoxin Conotoxins - chemistry Conotoxins - classification Conotoxins - isolation & purification Conus Conus Snail - chemistry Conus Snail - genetics data collection Databases, Protein Hidden Markov Model high-throughput nucleotide sequencing Markov chain Markov Chains Molecular Sequence Data neurophysiology Neurotoxins - chemistry Neurotoxins - classification Neurotoxins - isolation & purification peptides pharmacology Phylogeny prediction Protein Precursors - chemistry Protein Precursors - classification Protein Precursors - isolation & purification Protein prediction Protein Sorting Signals - physiology Sequence Analysis, Protein signal peptide snails Terminology as Topic toxins Transcriptome
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