Putative tumor suppressor miR‐145 inhibits colon cancer cell growth by targeting oncogene friend leukemia virus integration 1 gene

BACKGROUND: Tumor suppressor microRNA miR‐145 is commonly down‐regulated in colon carcinoma tissues, but its specific role in tumors remains unknown. METHODS: In this study, the authors identified the Friend leukemia virus integration 1 gene (FLI1) as a novel target of miR‐145. FLI1 is involved in t...

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Veröffentlicht in:	Cancer 2011-01, Vol.117 (1), p.86-95
Hauptverfasser:	Zhang, Jianjun, Guo, Haiyan, Zhang, He, Wang, Haibo, Qian, Guanxiang, Fan, Xianqun, Hoffman, Andrew R., Hu, Ji‐Fan, Ge, Shengfang
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Apoptosis Biological and medical sciences Cell Line, Tumor Cell Proliferation Chromosome translocations Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - pathology Computational Biology Ewing's sarcoma FLI1 FLI1 protein Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation Gene Targeting Genes, Tumor Suppressor Humans Integration Medical sciences microRNA MicroRNAs - pharmacology miRNA miR‐145 mRNA Mutation Oncogenes Protein Biosynthesis Proto-Oncogene Protein c-fli-1 - genetics Proto-Oncogene Protein c-fli-1 - metabolism Regulatory sequences Regulatory Sequences, Nucleic Acid Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Translation Tumor cell lines tumor suppressor Tumor suppressor genes Tumors
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