Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells

Summary Histone deacetylase (HDAC) plays an important role in cancer onset and progression. Therefore, inhibition of HDAC offers potential as an effective cancer treatment regimen. CG200745, (E)-N 1 -(3-(dimethylamino)propyl)-N 8 -hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide, is a novel HD...

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Veröffentlicht in:	Investigational new drugs 2012-04, Vol.30 (2), p.435-442
Hauptverfasser:	Oh, Eun-Taex, Park, Moon-Taek, Choi, Bo-Hwa, Ro, Seonggu, Choi, Eun-Kyung, Jeong, Seong-Yun, Park, Heon Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antibodies Antineoplastic Agents - pharmacology Apoptosis Cancer therapies Cell cycle Cell death Cell Death - drug effects Cell Line, Tumor Clinical trials Cloning Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cytotoxicity Differentiation Dose-Response Relationship, Drug Gene Expression Regulation, Neoplastic - drug effects Genes, Reporter Genomics Half-Life Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histones - metabolism Humans Hydroxamic Acids - pharmacology Inhibitor drugs Lysine Male MDM2 protein Medicine Medicine & Public Health Mutation Naphthalenes - pharmacology Oncology p53 protein Pharmacology Pharmacology/Toxicology Plasmids Preclinical Studies Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Stability Proteins Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Studies Time Factors Transcription factors Transcriptional Activation - drug effects Transfection Tumor Stem Cell Assay Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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