Limited Sampling Estimates of Epigallocatechin Gallate Exposures in Cirrhotic and Noncirrhotic Patients With Hepatitis C After Single Oral Doses of Green Tea Extract

Abstract Background Epigallocatechin-3-gallate (EGCG) has antiangiogenic, antioxidant, and antifibrotic properties that may have therapeutic potential for the treatment of cirrhosis induced by hepatitis C virus (HCV). However, cirrhosis might affect EGCG disposition and augment its reported dose-dep...

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Veröffentlicht in:	Clinical therapeutics 2012-12, Vol.34 (12), p.2279-2285.e1
Hauptverfasser:	Halegoua-De Marzio, Dina, MD, Kraft, Walter K., MD, Daskalakis, Constantine, ScD, Ying, Xie, PhD, Hawke, Roy L., PharmD, PhD, Navarro, Victor J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Administration, Oral Aged Antioxidants - adverse effects Antioxidants - pharmacokinetics Area Under Curve Biological and medical sciences Blood Catechin - adverse effects Catechin - analogs & derivatives Catechin - pharmacokinetics Cell culture cirrhosis Drinking water Drug dosages epigallocatechin-3-gallate (EGCG) Estimates Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen green tea extract (GTE) hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy hepatocellular carcinoma Hepatology hepatotoxicity Human viral diseases Humans Infectious diseases Internal Medicine Liver cirrhosis Liver Cirrhosis - drug therapy Liver Cirrhosis - pathology Liver Cirrhosis - virology Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical Education Medical sciences Middle Aged Other diseases. Semiology Pharmacology. Drug treatments Plant Extracts - adverse effects Plant Extracts - pharmacokinetics Plasma Studies Tea - chemistry Time Factors Tumors Viral diseases Viral hepatitis
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