Synthesis and properties of squaraine-modified DNA

Synthesis and properties of squaraine-modified DNA

The incorporation of squaraines into DNA via the phosphoramidite approach is described. High molar absorptivity, environment-sensitive fluorescence properties and intense CD effects render squaraines valuable building blocks for DNA-based optical probes and nanostructures.

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Veröffentlicht in:Organic & biomolecular chemistry 2012-12, Vol.10 (45), p.8944-8947
Hauptverfasser: Markova, Larysa I, Malinovskii, Vladimir L, Patsenker, Leonid D, Häner, Robert
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry Techniques, Synthetic
Cyclobutanes - chemistry
DNA
DNA - chemical synthesis
DNA - chemistry
Fluorescence
Fluorescent indicators
Oligodeoxyribonucleotides - chemical synthesis
Oligodeoxyribonucleotides - chemistry
Optical Phenomena
Organophosphorus Compounds - chemistry
Phenols - chemistry
Spectrum Analysis
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Beschreibung
Zusammenfassung:The incorporation of squaraines into DNA via the phosphoramidite approach is described. High molar absorptivity, environment-sensitive fluorescence properties and intense CD effects render squaraines valuable building blocks for DNA-based optical probes and nanostructures.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob26787j