Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

Long-acting nanoformulated antiretroviral therapy (nanoART) with improved pharmacokinetics, biodistribution and limited systemic toxicities will likely improve drug adherence and access to viral reservoirs. Atazanavir and ritonavir crystalline nanoART were formulated in a poloxamer-188 excipient by...

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Veröffentlicht in:	AIDS (London) 2012-11, Vol.26 (17), p.2135-2144
Hauptverfasser:	DASH, Prasanta K, GENDELMAN, Howard E, ROY, Upal, BALKUNDI, Shantanu, ALNOUTI, Yazen, MOSLEY, Rodney L, GELBARD, Harris A, MCMILLAN, Joellyn, GORANTLA, Santhi, POLUEKTOVA, Larisa Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens, CD34 - metabolism antiretroviral therapy Antiviral agents Atazanavir Sulfate Biological and medical sciences Blood Brain Brain - metabolism Brain - virology CD34 antigen CD4 antigen Dosage Forms Dose-Response Relationship, Drug Drug Carriers - chemistry Drug delivery Drug Delivery Systems - methods Drug development HIV-1 - drug effects Human immunodeficiency virus Human viral diseases Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunohistochemistry Immunopathology Infectious diseases Liver Lymphocytes T Medical sciences Mice Mice, Inbred NOD Microtubule-associated protein 2 Nanoparticles - chemistry Neurofilaments Neuroprotection Oligopeptides - pharmacokinetics Oligopeptides - pharmacology Pharmacokinetics Pharmacology. Drug treatments Pyridines - pharmacokinetics Pyridines - pharmacology Ritonavir Ritonavir - pharmacokinetics Ritonavir - pharmacology Spleen Stem cells Synaptophysin Toxicity Translation Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load - drug effects
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