Association of PAI‐1 gene polymorphism with survival and chemotherapy‐related vascular toxicity in testicular cancer

BACKGROUND: High Plasminogen‐Activator Inhibitor 1 (PAI‐1) expression by tumors has been associated with poor prognosis in several cancer types, and high systemic PAI‐1 levels with increased thrombosis risk. The authors investigated whether the germline 4G/5G deletion/insertion polymorphism in the P...

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Veröffentlicht in:	Cancer 2010-12, Vol.116 (24), p.5628-5636
Hauptverfasser:	de Haas, Esther C., Zwart, Nynke, Meijer, Coby, Suurmeijer, Albert J.H., Meijer, Karina, Guchelaar, Henk‐Jan, Hoekstra, Harald J., van Leeuwen, Flora E., Sleijfer, Dirk Th, Boezen, H. Marike, Gietema, Jourik A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Cardiovascular Diseases - chemically induced Factor V - genetics gene polymorphism Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Middle Aged PAI‐1 Plasminogen Activator Inhibitor 1 - genetics Platinum Compounds - adverse effects Platinum Compounds - therapeutic use Polymorphism, Genetic Prognosis Prothrombin - genetics Risk Factors survival testicular cancer Testicular Neoplasms - drug therapy Testicular Neoplasms - genetics Testicular Neoplasms - mortality Tumors vascular toxicity
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