Lipopolysaccharide induces a stromal-epithelial signalling axis in a rat model of chronic periodontitis

Aim Lipopolysaccharide is a bacterial virulence factor implicated in chronic periodontitis, which may penetrate the junctional epithelial barrier and basement membrane to insult underlying stroma. We sought to identify lipopolysaccharide‐induced global gene expression changes responsible for signall...

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Veröffentlicht in:	Journal of clinical periodontology 2013-01, Vol.40 (1), p.8-17
Hauptverfasser:	Firth, James D., Ekuni, Daisuke, Irie, Koichiro, Tomofuji, Takaaki, Morita, Manabu, Putnins, Edward E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin Animals bioinformatics Biological and medical sciences Cells, Cultured Chronic Periodontitis - metabolism Chronic Periodontitis - microbiology Dentistry EGF Family of Proteins epithelia Epithelial Attachment - cytology Epithelial Attachment - metabolism Epithelial Cells Facial bones, jaws, teeth, parodontium: diseases, semeiology Fas Ligand Protein - genetics fibroblast Fibroblasts Gene expression Gene Expression Profiling Glycoproteins - genetics Gum disease inflammation Intercellular Signaling Peptides and Proteins - genetics Interleukin-1beta - genetics Laser Capture Microdissection lipopolysaccharide Lipopolysaccharides - pharmacology Male Medical research Medical sciences Mucin-4 - genetics Non tumoral diseases Otorhinolaryngology. Stomatology Porphyromonas gingivalis - physiology Proto-Oncogene Proteins c-fos - genetics Rats Rats, Wistar Receptor, Epidermal Growth Factor - physiology Receptors, Somatostatin - genetics Signal Transduction - drug effects signalling Stromal Cells - metabolism
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