Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients
Abstract Background Atrial fibrillation occurs after approximately 25% to 45% of coronary artery bypass graft (CABG) surgeries. Oxidative stress and related electrophysiological remodeling has been proposed as a potential cause of this atrial fibrillation. Perioperative supplementation of the antiox...
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| Veröffentlicht in: | The American journal of surgery 2012-12, Vol.204 (6), p.862-867 |
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| creator | Bjordahl, Paul M., M.D Helmer, Stephen D., Ph.D Gosnell, Dawn J., M.S.N Wemmer, Gail E., A.D.N O'Hara, Walter W., M.D Milfeld, Douglas J., M.D |
| description | Abstract Background Atrial fibrillation occurs after approximately 25% to 45% of coronary artery bypass graft (CABG) surgeries. Oxidative stress and related electrophysiological remodeling has been proposed as a potential cause of this atrial fibrillation. Perioperative supplementation of the antioxidant ascorbic acid has been evaluated as a preventive agent. The current investigation was conducted to evaluate the efficacy of ascorbic acid in reducing atrial fibrillation in CABG patients. Methods A prospective, randomized, placebo-controlled, triple-blind, single-institution study was conducted in nonemergency CABG patients. Subjects were monitored for episodes of arrhythmia and other complications. Results Eighty-nine treatment and 96 control subjects completed the study protocol. Demographics, comorbidities, and preoperative drugs were similar between groups. Surgical characteristics and postoperative medication use also were similar. The incidence of atrial fibrillation was 30.3% in the treatment group and 30.2% in the control group ( P = .985). No difference was found in postoperative complications or mortality. Conclusions Our data indicate that supplementation of ascorbic acid in addition to routine postoperative care does not reduce atrial fibrillation after coronary artery bypass grafting. |
| doi_str_mv | 10.1016/j.amjsurg.2012.03.012 |
| format | Article |
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Oxidative stress and related electrophysiological remodeling has been proposed as a potential cause of this atrial fibrillation. Perioperative supplementation of the antioxidant ascorbic acid has been evaluated as a preventive agent. The current investigation was conducted to evaluate the efficacy of ascorbic acid in reducing atrial fibrillation in CABG patients. Methods A prospective, randomized, placebo-controlled, triple-blind, single-institution study was conducted in nonemergency CABG patients. Subjects were monitored for episodes of arrhythmia and other complications. Results Eighty-nine treatment and 96 control subjects completed the study protocol. Demographics, comorbidities, and preoperative drugs were similar between groups. Surgical characteristics and postoperative medication use also were similar. The incidence of atrial fibrillation was 30.3% in the treatment group and 30.2% in the control group ( P = .985). No difference was found in postoperative complications or mortality. Conclusions Our data indicate that supplementation of ascorbic acid in addition to routine postoperative care does not reduce atrial fibrillation after coronary artery bypass grafting.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2012.03.012</identifier><identifier>PMID: 23022248</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Aged ; Antioxidants - therapeutic use ; Ascorbic acid ; Ascorbic Acid - therapeutic use ; Atrial fibrillation ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - etiology ; Atrial Fibrillation - prevention & control ; Biological and medical sciences ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Chronic obstructive pulmonary disease ; Coronary Artery Bypass ; Coronary artery bypass grafting ; Dietary Supplements ; Double-Blind Method ; Drug Administration Schedule ; Enteral Nutrition ; Female ; General aspects ; Heart ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Mortality ; Perioperative Care - methods ; Postoperative arrhythmia ; Postoperative Complications - epidemiology ; Postoperative Complications - prevention & control ; Postoperative period ; Prevention and actions ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Surgery ; Treatment Outcome ; Vitamin C</subject><ispartof>The American journal of surgery, 2012-12, Vol.204 (6), p.862-867</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-3cdedf9f9628dfa44df74fc234bdc8ed8195f25792635ae4097745132ff86f743</citedby><cites>FETCH-LOGICAL-c478t-3cdedf9f9628dfa44df74fc234bdc8ed8195f25792635ae4097745132ff86f743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1223854783?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26765012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23022248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bjordahl, Paul M., M.D</creatorcontrib><creatorcontrib>Helmer, Stephen D., Ph.D</creatorcontrib><creatorcontrib>Gosnell, Dawn J., M.S.N</creatorcontrib><creatorcontrib>Wemmer, Gail E., A.D.N</creatorcontrib><creatorcontrib>O'Hara, Walter W., M.D</creatorcontrib><creatorcontrib>Milfeld, Douglas J., M.D</creatorcontrib><title>Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Atrial fibrillation occurs after approximately 25% to 45% of coronary artery bypass graft (CABG) surgeries. Oxidative stress and related electrophysiological remodeling has been proposed as a potential cause of this atrial fibrillation. Perioperative supplementation of the antioxidant ascorbic acid has been evaluated as a preventive agent. The current investigation was conducted to evaluate the efficacy of ascorbic acid in reducing atrial fibrillation in CABG patients. Methods A prospective, randomized, placebo-controlled, triple-blind, single-institution study was conducted in nonemergency CABG patients. Subjects were monitored for episodes of arrhythmia and other complications. Results Eighty-nine treatment and 96 control subjects completed the study protocol. Demographics, comorbidities, and preoperative drugs were similar between groups. Surgical characteristics and postoperative medication use also were similar. The incidence of atrial fibrillation was 30.3% in the treatment group and 30.2% in the control group ( P = .985). No difference was found in postoperative complications or mortality. Conclusions Our data indicate that supplementation of ascorbic acid in addition to routine postoperative care does not reduce atrial fibrillation after coronary artery bypass grafting.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Antioxidants - therapeutic use</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Coronary Artery Bypass</subject><subject>Coronary artery bypass grafting</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Enteral Nutrition</subject><subject>Female</subject><subject>General aspects</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Perioperative Care - methods</subject><subject>Postoperative arrhythmia</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Postoperative period</subject><subject>Prevention and actions</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Vitamin C</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkluL1TAUhYsozpnRn6AERPClNbfeXhQZHBUGFFTwLaTJzpja09SkPXJe_O3u0qMD8-LTIvCtnbUvWfaE0YJRVr3sC73v0xJvCk4ZL6goUO5lO9bUbc6aRtzPdpRSnrcVo2fZeUo9PhmT4mF2xgXlnMtml_3-BNGHCaKe_QFIWqZpgD2MM77DSH75-TvRyYTYeUO08ZbYAImMYSZThAOCRM_R64E430U_DJvPjwQ9YdTxSHScAaU7TjolchO1Qy9i6E2PsgdODwken_Qi-3r19svl-_z647sPl2-ucyPrZs6FsWBd69qKN9ZpKa2rpTNcyM6aBmzD2tLxsm55JUoNkrZ1LUsmuHNNhai4yF5sdacYfi6QZrX3yQDGHSEsSTEuGkbLWq7osztoH5Y4YjqkECsxkUCq3CgTQ0oRnJqi32O7ilG1Lkj16rQgtS5IUaFQ0Pf0VH3p9mD_uf5uBIHnJwDHrgcX9Wh8uuWquiq3Qq83DnBsBw9RJYMjNWB9BDMrG_x_o7y6U8EMfvT46Q84QrrtWiX0qM_rNa3HxDilUpbfxB8jPMiP</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Bjordahl, Paul M., M.D</creator><creator>Helmer, Stephen D., Ph.D</creator><creator>Gosnell, Dawn J., M.S.N</creator><creator>Wemmer, Gail E., A.D.N</creator><creator>O'Hara, Walter W., M.D</creator><creator>Milfeld, Douglas J., M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients</title><author>Bjordahl, Paul M., M.D ; Helmer, Stephen D., Ph.D ; Gosnell, Dawn J., M.S.N ; Wemmer, Gail E., A.D.N ; O'Hara, Walter W., M.D ; Milfeld, Douglas J., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-3cdedf9f9628dfa44df74fc234bdc8ed8195f25792635ae4097745132ff86f743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Antioxidants - therapeutic use</topic><topic>Ascorbic acid</topic><topic>Ascorbic Acid - therapeutic use</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Coronary Artery Bypass</topic><topic>Coronary artery bypass grafting</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Enteral Nutrition</topic><topic>Female</topic><topic>General aspects</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Perioperative Care - methods</topic><topic>Postoperative arrhythmia</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Postoperative period</topic><topic>Prevention and actions</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. 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Oxidative stress and related electrophysiological remodeling has been proposed as a potential cause of this atrial fibrillation. Perioperative supplementation of the antioxidant ascorbic acid has been evaluated as a preventive agent. The current investigation was conducted to evaluate the efficacy of ascorbic acid in reducing atrial fibrillation in CABG patients. Methods A prospective, randomized, placebo-controlled, triple-blind, single-institution study was conducted in nonemergency CABG patients. Subjects were monitored for episodes of arrhythmia and other complications. Results Eighty-nine treatment and 96 control subjects completed the study protocol. Demographics, comorbidities, and preoperative drugs were similar between groups. Surgical characteristics and postoperative medication use also were similar. The incidence of atrial fibrillation was 30.3% in the treatment group and 30.2% in the control group ( P = .985). No difference was found in postoperative complications or mortality. Conclusions Our data indicate that supplementation of ascorbic acid in addition to routine postoperative care does not reduce atrial fibrillation after coronary artery bypass grafting.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23022248</pmid><doi>10.1016/j.amjsurg.2012.03.012</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Oral Aged Antioxidants - therapeutic use Ascorbic acid Ascorbic Acid - therapeutic use Atrial fibrillation Atrial Fibrillation - epidemiology Atrial Fibrillation - etiology Atrial Fibrillation - prevention & control Biological and medical sciences Cardiac arrhythmia Cardiac dysrhythmias Cardiology. Vascular system Chronic obstructive pulmonary disease Coronary Artery Bypass Coronary artery bypass grafting Dietary Supplements Double-Blind Method Drug Administration Schedule Enteral Nutrition Female General aspects Heart Humans Incidence Male Medical sciences Middle Aged Mortality Perioperative Care - methods Postoperative arrhythmia Postoperative Complications - epidemiology Postoperative Complications - prevention & control Postoperative period Prevention and actions Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Surgery Treatment Outcome Vitamin C |
| title | Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients |
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