Mimicry of human sepsis in a rat model—Prospects and limitations

Abstract Background Sepsis and systemic inflammatory response syndrome (SIRS) continue to represent critical conditions with persistently high mortality and continue to need experimental and clinical research. We developed a rat model of gram-positive and gram-negative SIRS/sepsis with in vivo visua...

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Veröffentlicht in:	The Journal of surgical research 2013, Vol.179 (1), p.e167-e175
Hauptverfasser:	Stahl, Oliver, MD, Löffler, Bettina, MD, Haier, Joerg, MD, Mardin, Wolf Arif, MD, Mees, Soeren Torge, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphatoxin Animal model Animals Bacterial Toxins - administration & dosage Bacterial Toxins - adverse effects Disease Models, Animal Gram-negative Gram-positive Hemodynamics - physiology Hemolysin Proteins - administration & dosage Hemolysin Proteins - adverse effects Humans Injections, Intraperitoneal Leukocyte Lipopolysaccharides - administration & dosage Lipopolysaccharides - adverse effects LPS Lung - blood supply Lung - physiopathology Male Microcirculation - physiology Microscopy, Video Platelet Rats Rats, Sprague-Dawley Respiration Sepsis Sepsis - blood Sepsis - etiology Sepsis - physiopathology SIRS Surgery Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - physiopathology
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