Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

In vertebrates ecto-5′-nucleotidase (e5NT) catalyzes the hydrolysis of extracellular AMP to adenosine and represents the major control point for extracellular adenosine levels. Due to its pivotal role for activation of P1 adenosine receptors, e5NT has emerged as an appealing drug target for treatmen...

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Veröffentlicht in:	Structure (London) 2012-12, Vol.20 (12), p.2161-2173
Hauptverfasser:	Knapp, Karen, Zebisch, Matthias, Pippel, Jan, El-Tayeb, Ali, Müller, Christa E., Sträter, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - antagonists & inhibitors 5'-Nucleotidase - chemistry Adenosine - chemistry Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - chemistry Amino Acid Sequence Catalytic Domain Coordination Complexes - chemistry Crystallography, X-Ray Enzyme Inhibitors - chemistry Flavonoids - chemistry GPI-Linked Proteins - antagonists & inhibitors GPI-Linked Proteins - chemistry Humans Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Models, Molecular Molecular Sequence Data Protein Binding Protein Interaction Domains and Motifs Protein Structure, Quaternary Protein Structure, Secondary Protein Subunits - antagonists & inhibitors Protein Subunits - chemistry Signal Transduction Structural Homology, Protein Zinc - chemistry
Online-Zugang:	Volltext
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