Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case
This report describes the laparoscopic resection of a rectal GIST after treatment with imatinib mesylate. A 56-year-old male presented with a submucosal tumor (longest diameter, 8 cm) arising in the lower rectum. A core needle biopsy revealed that the tumor contained bundles of spindle-like cells. I...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2012-11, Vol.42 (11), p.1096-1099 |
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| container_title | Surgery today (Tokyo, Japan) |
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| creator | Nakamura, Takatoshi Mitomi, Hiroyuki Onozato, Wataru Sato, Takeo Ikeda, Atsushi Naito, Masanori Ogura, Naoto Kamata, Hiroki Ooki, Akira Watanabe, Masahiko |
| description | This report describes the laparoscopic resection of a rectal GIST after treatment with imatinib mesylate. A 56-year-old male presented with a submucosal tumor (longest diameter, 8 cm) arising in the lower rectum. A core needle biopsy revealed that the tumor contained bundles of spindle-like cells. Immunostaining revealed that the tumor was positive for c-kit and CD34. Analysis of the c-kit gene revealed a substitution of ACA (threonine) by GCA (alanine) at codon 574 of exon 11. Imatinib mesylate (400 mg/day) was given as preoperative adjuvant therapy for 3 months, and the tumor shrank to 5 cm in diameter. Proctectomy with transanal anastomosis could be performed laparoscopically, while preserving the anus. There was no evidence of recurrence 2 years 6 months after surgery. Preoperative adjuvant chemotherapy with imatinib mesylate may permit the use of less invasive treatment procedures, allowing anal preservation. |
| doi_str_mv | 10.1007/s00595-012-0134-8 |
| format | Article |
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A 56-year-old male presented with a submucosal tumor (longest diameter, 8 cm) arising in the lower rectum. A core needle biopsy revealed that the tumor contained bundles of spindle-like cells. Immunostaining revealed that the tumor was positive for c-kit and CD34. Analysis of the c-kit gene revealed a substitution of ACA (threonine) by GCA (alanine) at codon 574 of exon 11. Imatinib mesylate (400 mg/day) was given as preoperative adjuvant therapy for 3 months, and the tumor shrank to 5 cm in diameter. Proctectomy with transanal anastomosis could be performed laparoscopically, while preserving the anus. There was no evidence of recurrence 2 years 6 months after surgery. Preoperative adjuvant chemotherapy with imatinib mesylate may permit the use of less invasive treatment procedures, allowing anal preservation.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-012-0134-8</identifier><identifier>PMID: 22294424</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Antineoplastic Agents - administration & dosage ; Benzamides ; Biopsy, Fine-Needle ; Case Report ; Colectomy - methods ; Follow-Up Studies ; Gastrointestinal Stromal Tumors - drug therapy ; Gastrointestinal Stromal Tumors - pathology ; Gastrointestinal Stromal Tumors - surgery ; Humans ; Imatinib Mesylate ; Immunohistochemistry ; Laparoscopy - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoadjuvant Therapy - methods ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Piperazines - administration & dosage ; Preoperative Care - methods ; Pyrimidines - administration & dosage ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - pathology ; Rectal Neoplasms - surgery ; Risk Assessment ; Surgery ; Surgical Oncology ; Treatment Outcome</subject><ispartof>Surgery today (Tokyo, Japan), 2012-11, Vol.42 (11), p.1096-1099</ispartof><rights>Springer 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-b8643dcf8511a547125b719037f26fad2d8e54fe2d1616c39ae06da4504022dd3</citedby><cites>FETCH-LOGICAL-c397t-b8643dcf8511a547125b719037f26fad2d8e54fe2d1616c39ae06da4504022dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-012-0134-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-012-0134-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22294424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Takatoshi</creatorcontrib><creatorcontrib>Mitomi, Hiroyuki</creatorcontrib><creatorcontrib>Onozato, Wataru</creatorcontrib><creatorcontrib>Sato, Takeo</creatorcontrib><creatorcontrib>Ikeda, Atsushi</creatorcontrib><creatorcontrib>Naito, Masanori</creatorcontrib><creatorcontrib>Ogura, Naoto</creatorcontrib><creatorcontrib>Kamata, Hiroki</creatorcontrib><creatorcontrib>Ooki, Akira</creatorcontrib><creatorcontrib>Watanabe, Masahiko</creatorcontrib><title>Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>This report describes the laparoscopic resection of a rectal GIST after treatment with imatinib mesylate. A 56-year-old male presented with a submucosal tumor (longest diameter, 8 cm) arising in the lower rectum. A core needle biopsy revealed that the tumor contained bundles of spindle-like cells. Immunostaining revealed that the tumor was positive for c-kit and CD34. Analysis of the c-kit gene revealed a substitution of ACA (threonine) by GCA (alanine) at codon 574 of exon 11. Imatinib mesylate (400 mg/day) was given as preoperative adjuvant therapy for 3 months, and the tumor shrank to 5 cm in diameter. Proctectomy with transanal anastomosis could be performed laparoscopically, while preserving the anus. There was no evidence of recurrence 2 years 6 months after surgery. Preoperative adjuvant chemotherapy with imatinib mesylate may permit the use of less invasive treatment procedures, allowing anal preservation.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Benzamides</subject><subject>Biopsy, Fine-Needle</subject><subject>Case Report</subject><subject>Colectomy - methods</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal Stromal Tumors - drug therapy</subject><subject>Gastrointestinal Stromal Tumors - pathology</subject><subject>Gastrointestinal Stromal Tumors - surgery</subject><subject>Humans</subject><subject>Imatinib Mesylate</subject><subject>Immunohistochemistry</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy - methods</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Piperazines - administration & dosage</subject><subject>Preoperative Care - methods</subject><subject>Pyrimidines - administration & dosage</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - surgery</subject><subject>Risk Assessment</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Treatment Outcome</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhq2qqCzQH9BL5SOX0BnH-eqtQrQgrdQLnC2vM9kNSuLUdoQ48s-ZVYBjD9bI8vO-1jxCfEO4QoDqRwQomiIDVHxyndWfxAZ1Xmaqxvyz2ECjMUPV4Kk4i_ERQOka4Is4VUo1Wiu9ES9bO9vgo_Nz72SgSC71fpK-k1bubUzB91OimPrJDvJ4HXmmZfThyKQDccjxXdouUZApkE0jTUk-9ekg-9Fyst_JkeLzYBP9ZHz2Ia0fOBvpQpx0doj09W2ei4ffN_fXt9n275-761_bzOVNlbJdXeq8dV1dINpCV6iKXYUN5FWnys62qq2p0B2pFkssOWMJytbqAjQo1bb5ubhce-fg_y28kRn76GgY7ER-iQZVXhXAzSWjuKKOzcRAnZkDbxKeDYI5mjerecPmzdG8qTnz_a1-2Y3UfiTeVTOgViDy07SnYB79Ethq_E_rK-KpkE0</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Nakamura, Takatoshi</creator><creator>Mitomi, Hiroyuki</creator><creator>Onozato, Wataru</creator><creator>Sato, Takeo</creator><creator>Ikeda, Atsushi</creator><creator>Naito, Masanori</creator><creator>Ogura, Naoto</creator><creator>Kamata, Hiroki</creator><creator>Ooki, Akira</creator><creator>Watanabe, Masahiko</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case</title><author>Nakamura, Takatoshi ; Mitomi, Hiroyuki ; Onozato, Wataru ; Sato, Takeo ; Ikeda, Atsushi ; Naito, Masanori ; Ogura, Naoto ; Kamata, Hiroki ; Ooki, Akira ; Watanabe, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-b8643dcf8511a547125b719037f26fad2d8e54fe2d1616c39ae06da4504022dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antineoplastic Agents - administration & dosage</topic><topic>Benzamides</topic><topic>Biopsy, Fine-Needle</topic><topic>Case Report</topic><topic>Colectomy - methods</topic><topic>Follow-Up Studies</topic><topic>Gastrointestinal Stromal Tumors - drug therapy</topic><topic>Gastrointestinal Stromal Tumors - pathology</topic><topic>Gastrointestinal Stromal Tumors - surgery</topic><topic>Humans</topic><topic>Imatinib Mesylate</topic><topic>Immunohistochemistry</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy - methods</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Piperazines - administration & dosage</topic><topic>Preoperative Care - methods</topic><topic>Pyrimidines - administration & dosage</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - surgery</topic><topic>Risk Assessment</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Takatoshi</creatorcontrib><creatorcontrib>Mitomi, Hiroyuki</creatorcontrib><creatorcontrib>Onozato, Wataru</creatorcontrib><creatorcontrib>Sato, Takeo</creatorcontrib><creatorcontrib>Ikeda, Atsushi</creatorcontrib><creatorcontrib>Naito, Masanori</creatorcontrib><creatorcontrib>Ogura, Naoto</creatorcontrib><creatorcontrib>Kamata, Hiroki</creatorcontrib><creatorcontrib>Ooki, Akira</creatorcontrib><creatorcontrib>Watanabe, Masahiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Takatoshi</au><au>Mitomi, Hiroyuki</au><au>Onozato, Wataru</au><au>Sato, Takeo</au><au>Ikeda, Atsushi</au><au>Naito, Masanori</au><au>Ogura, Naoto</au><au>Kamata, Hiroki</au><au>Ooki, Akira</au><au>Watanabe, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>42</volume><issue>11</issue><spage>1096</spage><epage>1099</epage><pages>1096-1099</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>This report describes the laparoscopic resection of a rectal GIST after treatment with imatinib mesylate. A 56-year-old male presented with a submucosal tumor (longest diameter, 8 cm) arising in the lower rectum. A core needle biopsy revealed that the tumor contained bundles of spindle-like cells. Immunostaining revealed that the tumor was positive for c-kit and CD34. Analysis of the c-kit gene revealed a substitution of ACA (threonine) by GCA (alanine) at codon 574 of exon 11. Imatinib mesylate (400 mg/day) was given as preoperative adjuvant therapy for 3 months, and the tumor shrank to 5 cm in diameter. Proctectomy with transanal anastomosis could be performed laparoscopically, while preserving the anus. There was no evidence of recurrence 2 years 6 months after surgery. Preoperative adjuvant chemotherapy with imatinib mesylate may permit the use of less invasive treatment procedures, allowing anal preservation.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>22294424</pmid><doi>10.1007/s00595-012-0134-8</doi><tpages>4</tpages></addata></record> |
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| subjects | Antineoplastic Agents - administration & dosage Benzamides Biopsy, Fine-Needle Case Report Colectomy - methods Follow-Up Studies Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - surgery Humans Imatinib Mesylate Immunohistochemistry Laparoscopy - methods Male Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy - methods Neoplasm Invasiveness - pathology Neoplasm Staging Piperazines - administration & dosage Preoperative Care - methods Pyrimidines - administration & dosage Rectal Neoplasms - drug therapy Rectal Neoplasms - pathology Rectal Neoplasms - surgery Risk Assessment Surgery Surgical Oncology Treatment Outcome |
| title | Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case |
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