Positive correlation of paraoxonase 1 (PON1) activity with serum insulin level and HOMA-IR in dementia. A possible advantageous role of PON1 in dementia development
Abstract Paraoxonase 1 (PON1) activity and metabolic syndrome traits were evaluated in 169 demented patients (81 recognized as AD, 32 as VaD, 56 as MD) and in 64 control individuals. Paraoxonase activity was determined spectrophotometrically using phenyloacetate as substrate. Metabolic syndrome was...
Gespeichert in:
| Veröffentlicht in: | Journal of the neurological sciences 2013-01, Vol.324 (1), p.172-175 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 175 |
|---|---|
| container_issue | 1 |
| container_start_page | 172 |
| container_title | Journal of the neurological sciences |
| container_volume | 324 |
| creator | Bednarska-Makaruk, Małgorzata Graban, Ałła Lipczyńska-Łojkowska, Wanda Bochyńska, Anna Rodo, Maria Krzywkowski, Tomasz Ryglewicz, Danuta Wehr, Hanna |
| description | Abstract Paraoxonase 1 (PON1) activity and metabolic syndrome traits were evaluated in 169 demented patients (81 recognized as AD, 32 as VaD, 56 as MD) and in 64 control individuals. Paraoxonase activity was determined spectrophotometrically using phenyloacetate as substrate. Metabolic syndrome was recognized according to AHA/NHLBI criteria. In the whole group with dementia significant positive correlation between PON1 activity/HDL cholesterol ratio (i.e. HDL corrected PON1 activity) and insulin level as well as HOMA IR index, was observed. The multivariate analysis showed that the PON1/HDL-C ratio was also significantly positively associated with the presence of metabolic syndrome (with insulin resistance as a major underlying trait) both in dementia and in control group. High insulin level and HOMA-IR are considered to be the traits of insulin resistance. It has however to be taken into account that they both could also depend on insulin production and release which, as was recently stated in cell experiments, are enhanced by PON1. The observed positive correlation suggests an advantageous role of the enzyme in metabolic syndrome influence on dementia development. |
| doi_str_mv | 10.1016/j.jns.2012.11.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1237503713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022510X12005904</els_id><sourcerecordid>1237503713</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-db8cf46ca30b1d2971e1c6743b6b1eabf2d3946405664f150b3b23c61067d1943</originalsourceid><addsrcrecordid>eNp9kttu1DAQhiMEotvCA3CDfINULhI8duIkQkJaVUArFbbiIHFnOc4EHLJ2sJMt-z48KI52OYgLrnz6_pnx_JMkj4BmQEE867PehoxRYBlARim_k6ygKqu0qCp-N1lRylhaAP10kpyG0FNKRVXV95MTxqFieV2ukh83LpjJ7JBo5z0OajLOEteRUXnlvjurAhIg5zebt_CUKB1RM-3JrZm-kIB-3hJjwzwYSwbc4UCUbcnl5s06vXoXX0iLW7STURlZk9GFYJoBiWp3yk7qM7o5EO_iTcy3JPhbETcxnhuX04PkXqeGgA-P61ny8dXLDxeX6fXm9dXF-jrVOa-mtG0q3eVCK04baFldAoIWZc4b0QCqpmMtr3OR00KIvIOCNrxhXAugomyhzvlZcn6IO3r3bcYwya0JGodB2aVWCYyXBeUl8IjCAdU-fstjJ0dvtsrvJVC5mCN7Gc2RizkSQEZzoubxMfzcbLH9rfjlRgSeHAEVtBo6r6w24Q8nKgaiEJF7fuAwNmNn0MugDVqNrfGoJ9k6898yXvyj1tE_ExN-xT2G3s3exi5LkIFJKt8vU7QMETBKi5rm_Cc7j8HF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1237503713</pqid></control><display><type>article</type><title>Positive correlation of paraoxonase 1 (PON1) activity with serum insulin level and HOMA-IR in dementia. A possible advantageous role of PON1 in dementia development</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Bednarska-Makaruk, Małgorzata ; Graban, Ałła ; Lipczyńska-Łojkowska, Wanda ; Bochyńska, Anna ; Rodo, Maria ; Krzywkowski, Tomasz ; Ryglewicz, Danuta ; Wehr, Hanna</creator><creatorcontrib>Bednarska-Makaruk, Małgorzata ; Graban, Ałła ; Lipczyńska-Łojkowska, Wanda ; Bochyńska, Anna ; Rodo, Maria ; Krzywkowski, Tomasz ; Ryglewicz, Danuta ; Wehr, Hanna</creatorcontrib><description>Abstract Paraoxonase 1 (PON1) activity and metabolic syndrome traits were evaluated in 169 demented patients (81 recognized as AD, 32 as VaD, 56 as MD) and in 64 control individuals. Paraoxonase activity was determined spectrophotometrically using phenyloacetate as substrate. Metabolic syndrome was recognized according to AHA/NHLBI criteria. In the whole group with dementia significant positive correlation between PON1 activity/HDL cholesterol ratio (i.e. HDL corrected PON1 activity) and insulin level as well as HOMA IR index, was observed. The multivariate analysis showed that the PON1/HDL-C ratio was also significantly positively associated with the presence of metabolic syndrome (with insulin resistance as a major underlying trait) both in dementia and in control group. High insulin level and HOMA-IR are considered to be the traits of insulin resistance. It has however to be taken into account that they both could also depend on insulin production and release which, as was recently stated in cell experiments, are enhanced by PON1. The observed positive correlation suggests an advantageous role of the enzyme in metabolic syndrome influence on dementia development.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2012.11.003</identifier><identifier>PMID: 23182497</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Aged ; Aryldialkylphosphatase - blood ; Biological and medical sciences ; Blood Glucose - metabolism ; Cholesterol - blood ; Cholesterol, HDL - blood ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Dementia - blood ; Dementia - enzymology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Insulin - blood ; Insulin resistance ; Insulin Resistance - physiology ; International Classification of Diseases ; Male ; Medical sciences ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Multivariate Analysis ; Neurology ; Neuropsychological Tests ; Paraoxonase ; Triglycerides - blood</subject><ispartof>Journal of the neurological sciences, 2013-01, Vol.324 (1), p.172-175</ispartof><rights>Elsevier B.V.</rights><rights>2012 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-db8cf46ca30b1d2971e1c6743b6b1eabf2d3946405664f150b3b23c61067d1943</citedby><cites>FETCH-LOGICAL-c438t-db8cf46ca30b1d2971e1c6743b6b1eabf2d3946405664f150b3b23c61067d1943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2012.11.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26821656$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23182497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bednarska-Makaruk, Małgorzata</creatorcontrib><creatorcontrib>Graban, Ałła</creatorcontrib><creatorcontrib>Lipczyńska-Łojkowska, Wanda</creatorcontrib><creatorcontrib>Bochyńska, Anna</creatorcontrib><creatorcontrib>Rodo, Maria</creatorcontrib><creatorcontrib>Krzywkowski, Tomasz</creatorcontrib><creatorcontrib>Ryglewicz, Danuta</creatorcontrib><creatorcontrib>Wehr, Hanna</creatorcontrib><title>Positive correlation of paraoxonase 1 (PON1) activity with serum insulin level and HOMA-IR in dementia. A possible advantageous role of PON1 in dementia development</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Abstract Paraoxonase 1 (PON1) activity and metabolic syndrome traits were evaluated in 169 demented patients (81 recognized as AD, 32 as VaD, 56 as MD) and in 64 control individuals. Paraoxonase activity was determined spectrophotometrically using phenyloacetate as substrate. Metabolic syndrome was recognized according to AHA/NHLBI criteria. In the whole group with dementia significant positive correlation between PON1 activity/HDL cholesterol ratio (i.e. HDL corrected PON1 activity) and insulin level as well as HOMA IR index, was observed. The multivariate analysis showed that the PON1/HDL-C ratio was also significantly positively associated with the presence of metabolic syndrome (with insulin resistance as a major underlying trait) both in dementia and in control group. High insulin level and HOMA-IR are considered to be the traits of insulin resistance. It has however to be taken into account that they both could also depend on insulin production and release which, as was recently stated in cell experiments, are enhanced by PON1. The observed positive correlation suggests an advantageous role of the enzyme in metabolic syndrome influence on dementia development.</description><subject>Aged</subject><subject>Aryldialkylphosphatase - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Dementia - blood</subject><subject>Dementia - enzymology</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>International Classification of Diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Multivariate Analysis</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Paraoxonase</subject><subject>Triglycerides - blood</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kttu1DAQhiMEotvCA3CDfINULhI8duIkQkJaVUArFbbiIHFnOc4EHLJ2sJMt-z48KI52OYgLrnz6_pnx_JMkj4BmQEE867PehoxRYBlARim_k6ygKqu0qCp-N1lRylhaAP10kpyG0FNKRVXV95MTxqFieV2ukh83LpjJ7JBo5z0OajLOEteRUXnlvjurAhIg5zebt_CUKB1RM-3JrZm-kIB-3hJjwzwYSwbc4UCUbcnl5s06vXoXX0iLW7STURlZk9GFYJoBiWp3yk7qM7o5EO_iTcy3JPhbETcxnhuX04PkXqeGgA-P61ny8dXLDxeX6fXm9dXF-jrVOa-mtG0q3eVCK04baFldAoIWZc4b0QCqpmMtr3OR00KIvIOCNrxhXAugomyhzvlZcn6IO3r3bcYwya0JGodB2aVWCYyXBeUl8IjCAdU-fstjJ0dvtsrvJVC5mCN7Gc2RizkSQEZzoubxMfzcbLH9rfjlRgSeHAEVtBo6r6w24Q8nKgaiEJF7fuAwNmNn0MugDVqNrfGoJ9k6898yXvyj1tE_ExN-xT2G3s3exi5LkIFJKt8vU7QMETBKi5rm_Cc7j8HF</recordid><startdate>20130115</startdate><enddate>20130115</enddate><creator>Bednarska-Makaruk, Małgorzata</creator><creator>Graban, Ałła</creator><creator>Lipczyńska-Łojkowska, Wanda</creator><creator>Bochyńska, Anna</creator><creator>Rodo, Maria</creator><creator>Krzywkowski, Tomasz</creator><creator>Ryglewicz, Danuta</creator><creator>Wehr, Hanna</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130115</creationdate><title>Positive correlation of paraoxonase 1 (PON1) activity with serum insulin level and HOMA-IR in dementia. A possible advantageous role of PON1 in dementia development</title><author>Bednarska-Makaruk, Małgorzata ; Graban, Ałła ; Lipczyńska-Łojkowska, Wanda ; Bochyńska, Anna ; Rodo, Maria ; Krzywkowski, Tomasz ; Ryglewicz, Danuta ; Wehr, Hanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-db8cf46ca30b1d2971e1c6743b6b1eabf2d3946405664f150b3b23c61067d1943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aryldialkylphosphatase - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>Dementia - blood</topic><topic>Dementia - enzymology</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>International Classification of Diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Multivariate Analysis</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Paraoxonase</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bednarska-Makaruk, Małgorzata</creatorcontrib><creatorcontrib>Graban, Ałła</creatorcontrib><creatorcontrib>Lipczyńska-Łojkowska, Wanda</creatorcontrib><creatorcontrib>Bochyńska, Anna</creatorcontrib><creatorcontrib>Rodo, Maria</creatorcontrib><creatorcontrib>Krzywkowski, Tomasz</creatorcontrib><creatorcontrib>Ryglewicz, Danuta</creatorcontrib><creatorcontrib>Wehr, Hanna</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bednarska-Makaruk, Małgorzata</au><au>Graban, Ałła</au><au>Lipczyńska-Łojkowska, Wanda</au><au>Bochyńska, Anna</au><au>Rodo, Maria</au><au>Krzywkowski, Tomasz</au><au>Ryglewicz, Danuta</au><au>Wehr, Hanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive correlation of paraoxonase 1 (PON1) activity with serum insulin level and HOMA-IR in dementia. A possible advantageous role of PON1 in dementia development</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2013-01-15</date><risdate>2013</risdate><volume>324</volume><issue>1</issue><spage>172</spage><epage>175</epage><pages>172-175</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Abstract Paraoxonase 1 (PON1) activity and metabolic syndrome traits were evaluated in 169 demented patients (81 recognized as AD, 32 as VaD, 56 as MD) and in 64 control individuals. Paraoxonase activity was determined spectrophotometrically using phenyloacetate as substrate. Metabolic syndrome was recognized according to AHA/NHLBI criteria. In the whole group with dementia significant positive correlation between PON1 activity/HDL cholesterol ratio (i.e. HDL corrected PON1 activity) and insulin level as well as HOMA IR index, was observed. The multivariate analysis showed that the PON1/HDL-C ratio was also significantly positively associated with the presence of metabolic syndrome (with insulin resistance as a major underlying trait) both in dementia and in control group. High insulin level and HOMA-IR are considered to be the traits of insulin resistance. It has however to be taken into account that they both could also depend on insulin production and release which, as was recently stated in cell experiments, are enhanced by PON1. The observed positive correlation suggests an advantageous role of the enzyme in metabolic syndrome influence on dementia development.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>23182497</pmid><doi>10.1016/j.jns.2012.11.003</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 2013-01, Vol.324 (1), p.172-175 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1237503713 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Aryldialkylphosphatase - blood Biological and medical sciences Blood Glucose - metabolism Cholesterol - blood Cholesterol, HDL - blood Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - blood Dementia - enzymology Diagnostic and Statistical Manual of Mental Disorders Female Humans Insulin - blood Insulin resistance Insulin Resistance - physiology International Classification of Diseases Male Medical sciences Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - complications Multivariate Analysis Neurology Neuropsychological Tests Paraoxonase Triglycerides - blood |
| title | Positive correlation of paraoxonase 1 (PON1) activity with serum insulin level and HOMA-IR in dementia. A possible advantageous role of PON1 in dementia development |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T01%3A43%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Positive%20correlation%20of%20paraoxonase%201%20(PON1)%20activity%20with%20serum%20insulin%20level%20and%20HOMA-IR%20in%20dementia.%20A%20possible%20advantageous%20role%20of%20PON1%20in%20dementia%20development&rft.jtitle=Journal%20of%20the%20neurological%20sciences&rft.au=Bednarska-Makaruk,%20Ma%C5%82gorzata&rft.date=2013-01-15&rft.volume=324&rft.issue=1&rft.spage=172&rft.epage=175&rft.pages=172-175&rft.issn=0022-510X&rft.eissn=1878-5883&rft.coden=JNSCAG&rft_id=info:doi/10.1016/j.jns.2012.11.003&rft_dat=%3Cproquest_cross%3E1237503713%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1237503713&rft_id=info:pmid/23182497&rft_els_id=S0022510X12005904&rfr_iscdi=true |