Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF-I axis?
Summary Background A specific acromegaly‐related cardiomyopathy has been described in the literature, largely in Caucasians, which is independent of other risk factors, mainly hypertension. Objective This study assessed the cardiac changes in acromegalics of significant ethnic diversity and also the...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2013-01, Vol.78 (1), p.94-101 |
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| creator | Nascimento, Gilvan Cortês de Oliveira, Marina Torres Carvalho, Viviane Chaves Lopes, Maria Honorina Cordeiro Guimarães Sá, Adriana Maria Souza, Marinilde Teles de Souza Paiva Ferreira, Adalgisa Ferreira, Pedro Antônio Muniz Faria, Manuel dos Santos |
| description | Summary
Background
A specific acromegaly‐related cardiomyopathy has been described in the literature, largely in Caucasians, which is independent of other risk factors, mainly hypertension.
Objective
This study assessed the cardiac changes in acromegalics of significant ethnic diversity and also the relevance of the aetiopathogenic factors involved, such as disease activity and hypertension.
Design
It is a cross‐sectional study with a comparative control group.
Patients and methods
In this study, 37 acromegalic patients (20 Intermediate‐skinned (IS), 14 Dark‐skinned (DS) and three Light‐skinned (LS) individuals) and 74 controls matched by age, gender and hypertension were evaluated. Cardiac morphology and function were addressed using echocardiography parameters.
Results
The mean age of patients was 46·9 ± 12·8 years, with 67·6% being women and 43·2% hypertensive. The prevalence of left ventricular hypertrophy (LVH) between acromegalics was 56·8% vs 10·8% in the controls (P |
| doi_str_mv | 10.1111/j.1365-2265.2012.04472.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1237501817</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3377139031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4652-e959c32a224cc8aa4614955adc8f942c8d7be86ad13fb29854304f8d2e194cbd3</originalsourceid><addsrcrecordid>eNqNkV-L1DAUxYMo7rj6FSQggi_tJmnSP4LIMu52BnZHkBV9C3fS1M3YNmPSavvtTZ3ZEXwyLzeQ37n35hyEMCUxDediF9MkFRFjqYgZoSwmnGcsHh-hxenhMVqQhJCIpCk_Q8-83xFCRE6yp-iMsYwERCyQulTOtvobNEZhBa4ytp3sHvr7CZsOQ4f12OvOm5-6mTBUrRl1hfd2PzTQG9u9xcbj_l47jQE722hcW4fL1cW6vI7WGEbj3z9HT2povH5xrOfo8_XV3XIV3Xws18vLm0jxVLBIF6JQCQPGuFI5AE8pL4SASuV1wZnKq2yr8xQqmtRbVuSCJ4TXecU0LbjaVsk5enPou3f2x6B9L1vjlW4a6LQdvKQsyQShOc0C-uofdGcH14XtJBVc5AWjTAQqP1DBI--druXemRbcJCmRcxByJ2e_5ey3nIOQf4KQY5C-PA4Ytq2uTsIH5wPw-giAV9DUDjpl_F8uzXj4Fg_cuwP3yzR6-u8F5PJqM9-CPjroje_1eNKD-y7TLPghv2xKuSrF19sPm0_yLvkNpaGxaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545892125</pqid></control><display><type>article</type><title>Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF-I axis?</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Nascimento, Gilvan Cortês ; de Oliveira, Marina Torres ; Carvalho, Viviane Chaves ; Lopes, Maria Honorina Cordeiro ; Guimarães Sá, Adriana Maria ; Souza, Marinilde Teles ; de Souza Paiva Ferreira, Adalgisa ; Ferreira, Pedro Antônio Muniz ; Faria, Manuel dos Santos</creator><creatorcontrib>Nascimento, Gilvan Cortês ; de Oliveira, Marina Torres ; Carvalho, Viviane Chaves ; Lopes, Maria Honorina Cordeiro ; Guimarães Sá, Adriana Maria ; Souza, Marinilde Teles ; de Souza Paiva Ferreira, Adalgisa ; Ferreira, Pedro Antônio Muniz ; Faria, Manuel dos Santos</creatorcontrib><description>Summary
Background
A specific acromegaly‐related cardiomyopathy has been described in the literature, largely in Caucasians, which is independent of other risk factors, mainly hypertension.
Objective
This study assessed the cardiac changes in acromegalics of significant ethnic diversity and also the relevance of the aetiopathogenic factors involved, such as disease activity and hypertension.
Design
It is a cross‐sectional study with a comparative control group.
Patients and methods
In this study, 37 acromegalic patients (20 Intermediate‐skinned (IS), 14 Dark‐skinned (DS) and three Light‐skinned (LS) individuals) and 74 controls matched by age, gender and hypertension were evaluated. Cardiac morphology and function were addressed using echocardiography parameters.
Results
The mean age of patients was 46·9 ± 12·8 years, with 67·6% being women and 43·2% hypertensive. The prevalence of left ventricular hypertrophy (LVH) between acromegalics was 56·8% vs 10·8% in the controls (P < 0·001). About 86% of patients with LVH had active disease (P = 0·023). Logistic regression revealed that disease activity presented a stronger association (OR = 5·925; CI = 1·085–32·351; P = 0·040) with LVH than hypertension (OR = 3·237; CI = 0·702–14·924; P = 0·132). When DS acromegalics were compared with IS ones, no statistically significant differences were observed.
Conclusion
Chronically hyperactive somatotropic axis remains as an independent and determining factor in the development of left ventricular hypertrophy, as it is more associated with this condition than hypertension in a largely admixed population with a high degree of African ancestry.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2012.04472.x</identifier><identifier>PMID: 22702655</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Acromegaly - complications ; Acromegaly - epidemiology ; Acromegaly - metabolism ; Adult ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathies - epidemiology ; Cardiomyopathies - etiology ; Cross-Sectional Studies ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Heart ; Human Growth Hormone - metabolism ; Humans ; Hypothalamus. Hypophysis. Epiphysis (diseases) ; Insulin-Like Growth Factor I - metabolism ; Male ; Medical sciences ; Middle Aged ; Myocarditis. Cardiomyopathies ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2013-01, Vol.78 (1), p.94-101</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2012 Blackwell Publishing Ltd.</rights><rights>Copyright © 2013 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4652-e959c32a224cc8aa4614955adc8f942c8d7be86ad13fb29854304f8d2e194cbd3</citedby><cites>FETCH-LOGICAL-c4652-e959c32a224cc8aa4614955adc8f942c8d7be86ad13fb29854304f8d2e194cbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2012.04472.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2012.04472.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26741944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22702655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nascimento, Gilvan Cortês</creatorcontrib><creatorcontrib>de Oliveira, Marina Torres</creatorcontrib><creatorcontrib>Carvalho, Viviane Chaves</creatorcontrib><creatorcontrib>Lopes, Maria Honorina Cordeiro</creatorcontrib><creatorcontrib>Guimarães Sá, Adriana Maria</creatorcontrib><creatorcontrib>Souza, Marinilde Teles</creatorcontrib><creatorcontrib>de Souza Paiva Ferreira, Adalgisa</creatorcontrib><creatorcontrib>Ferreira, Pedro Antônio Muniz</creatorcontrib><creatorcontrib>Faria, Manuel dos Santos</creatorcontrib><title>Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF-I axis?</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Background
A specific acromegaly‐related cardiomyopathy has been described in the literature, largely in Caucasians, which is independent of other risk factors, mainly hypertension.
Objective
This study assessed the cardiac changes in acromegalics of significant ethnic diversity and also the relevance of the aetiopathogenic factors involved, such as disease activity and hypertension.
Design
It is a cross‐sectional study with a comparative control group.
Patients and methods
In this study, 37 acromegalic patients (20 Intermediate‐skinned (IS), 14 Dark‐skinned (DS) and three Light‐skinned (LS) individuals) and 74 controls matched by age, gender and hypertension were evaluated. Cardiac morphology and function were addressed using echocardiography parameters.
Results
The mean age of patients was 46·9 ± 12·8 years, with 67·6% being women and 43·2% hypertensive. The prevalence of left ventricular hypertrophy (LVH) between acromegalics was 56·8% vs 10·8% in the controls (P < 0·001). About 86% of patients with LVH had active disease (P = 0·023). Logistic regression revealed that disease activity presented a stronger association (OR = 5·925; CI = 1·085–32·351; P = 0·040) with LVH than hypertension (OR = 3·237; CI = 0·702–14·924; P = 0·132). When DS acromegalics were compared with IS ones, no statistically significant differences were observed.
Conclusion
Chronically hyperactive somatotropic axis remains as an independent and determining factor in the development of left ventricular hypertrophy, as it is more associated with this condition than hypertension in a largely admixed population with a high degree of African ancestry.</description><subject>Acromegaly - complications</subject><subject>Acromegaly - epidemiology</subject><subject>Acromegaly - metabolism</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies - epidemiology</subject><subject>Cardiomyopathies - etiology</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Human Growth Hormone - metabolism</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis (diseases)</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV-L1DAUxYMo7rj6FSQggi_tJmnSP4LIMu52BnZHkBV9C3fS1M3YNmPSavvtTZ3ZEXwyLzeQ37n35hyEMCUxDediF9MkFRFjqYgZoSwmnGcsHh-hxenhMVqQhJCIpCk_Q8-83xFCRE6yp-iMsYwERCyQulTOtvobNEZhBa4ytp3sHvr7CZsOQ4f12OvOm5-6mTBUrRl1hfd2PzTQG9u9xcbj_l47jQE722hcW4fL1cW6vI7WGEbj3z9HT2povH5xrOfo8_XV3XIV3Xws18vLm0jxVLBIF6JQCQPGuFI5AE8pL4SASuV1wZnKq2yr8xQqmtRbVuSCJ4TXecU0LbjaVsk5enPou3f2x6B9L1vjlW4a6LQdvKQsyQShOc0C-uofdGcH14XtJBVc5AWjTAQqP1DBI--druXemRbcJCmRcxByJ2e_5ey3nIOQf4KQY5C-PA4Ytq2uTsIH5wPw-giAV9DUDjpl_F8uzXj4Fg_cuwP3yzR6-u8F5PJqM9-CPjroje_1eNKD-y7TLPghv2xKuSrF19sPm0_yLvkNpaGxaw</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Nascimento, Gilvan Cortês</creator><creator>de Oliveira, Marina Torres</creator><creator>Carvalho, Viviane Chaves</creator><creator>Lopes, Maria Honorina Cordeiro</creator><creator>Guimarães Sá, Adriana Maria</creator><creator>Souza, Marinilde Teles</creator><creator>de Souza Paiva Ferreira, Adalgisa</creator><creator>Ferreira, Pedro Antônio Muniz</creator><creator>Faria, Manuel dos Santos</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF-I axis?</title><author>Nascimento, Gilvan Cortês ; de Oliveira, Marina Torres ; Carvalho, Viviane Chaves ; Lopes, Maria Honorina Cordeiro ; Guimarães Sá, Adriana Maria ; Souza, Marinilde Teles ; de Souza Paiva Ferreira, Adalgisa ; Ferreira, Pedro Antônio Muniz ; Faria, Manuel dos Santos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4652-e959c32a224cc8aa4614955adc8f942c8d7be86ad13fb29854304f8d2e194cbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acromegaly - complications</topic><topic>Acromegaly - epidemiology</topic><topic>Acromegaly - metabolism</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies - epidemiology</topic><topic>Cardiomyopathies - etiology</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Human Growth Hormone - metabolism</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis (diseases)</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nascimento, Gilvan Cortês</creatorcontrib><creatorcontrib>de Oliveira, Marina Torres</creatorcontrib><creatorcontrib>Carvalho, Viviane Chaves</creatorcontrib><creatorcontrib>Lopes, Maria Honorina Cordeiro</creatorcontrib><creatorcontrib>Guimarães Sá, Adriana Maria</creatorcontrib><creatorcontrib>Souza, Marinilde Teles</creatorcontrib><creatorcontrib>de Souza Paiva Ferreira, Adalgisa</creatorcontrib><creatorcontrib>Ferreira, Pedro Antônio Muniz</creatorcontrib><creatorcontrib>Faria, Manuel dos Santos</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nascimento, Gilvan Cortês</au><au>de Oliveira, Marina Torres</au><au>Carvalho, Viviane Chaves</au><au>Lopes, Maria Honorina Cordeiro</au><au>Guimarães Sá, Adriana Maria</au><au>Souza, Marinilde Teles</au><au>de Souza Paiva Ferreira, Adalgisa</au><au>Ferreira, Pedro Antônio Muniz</au><au>Faria, Manuel dos Santos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF-I axis?</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2013-01</date><risdate>2013</risdate><volume>78</volume><issue>1</issue><spage>94</spage><epage>101</epage><pages>94-101</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Background
A specific acromegaly‐related cardiomyopathy has been described in the literature, largely in Caucasians, which is independent of other risk factors, mainly hypertension.
Objective
This study assessed the cardiac changes in acromegalics of significant ethnic diversity and also the relevance of the aetiopathogenic factors involved, such as disease activity and hypertension.
Design
It is a cross‐sectional study with a comparative control group.
Patients and methods
In this study, 37 acromegalic patients (20 Intermediate‐skinned (IS), 14 Dark‐skinned (DS) and three Light‐skinned (LS) individuals) and 74 controls matched by age, gender and hypertension were evaluated. Cardiac morphology and function were addressed using echocardiography parameters.
Results
The mean age of patients was 46·9 ± 12·8 years, with 67·6% being women and 43·2% hypertensive. The prevalence of left ventricular hypertrophy (LVH) between acromegalics was 56·8% vs 10·8% in the controls (P < 0·001). About 86% of patients with LVH had active disease (P = 0·023). Logistic regression revealed that disease activity presented a stronger association (OR = 5·925; CI = 1·085–32·351; P = 0·040) with LVH than hypertension (OR = 3·237; CI = 0·702–14·924; P = 0·132). When DS acromegalics were compared with IS ones, no statistically significant differences were observed.
Conclusion
Chronically hyperactive somatotropic axis remains as an independent and determining factor in the development of left ventricular hypertrophy, as it is more associated with this condition than hypertension in a largely admixed population with a high degree of African ancestry.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22702655</pmid><doi>10.1111/j.1365-2265.2012.04472.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical endocrinology (Oxford), 2013-01, Vol.78 (1), p.94-101 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acromegaly - complications Acromegaly - epidemiology Acromegaly - metabolism Adult Biological and medical sciences Cardiology. Vascular system Cardiomyopathies - epidemiology Cardiomyopathies - etiology Cross-Sectional Studies Endocrinopathies Female Fundamental and applied biological sciences. Psychology Heart Human Growth Hormone - metabolism Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Insulin-Like Growth Factor I - metabolism Male Medical sciences Middle Aged Myocarditis. Cardiomyopathies Non tumoral diseases. Target tissue resistance. Benign neoplasms Vertebrates: endocrinology |
| title | Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF-I axis? |
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