Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol
► Vitamin E was linked to O6-succinylated chitosan and glycol chitosan. ► Resulting conjugates formed self-assembled nanoparticles in aqueous solution. ► Almost constant release rates were observed during the first 7h. ► Self-assembled nanoparticles exhibited antioxidant activity. ► Resulting nanopa...
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| Veröffentlicht in: | Carbohydrate polymers 2013-01, Vol.92 (1), p.856-864 |
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| creator | Quiñones, Javier Pérez Gothelf, Kurt Vesterager Kjems, Jørgen Yang, Chuanxu Caballero, Angeles María Heras Schmidt, Claudia Covas, Carlos Peniche |
| description | ► Vitamin E was linked to O6-succinylated chitosan and glycol chitosan. ► Resulting conjugates formed self-assembled nanoparticles in aqueous solution. ► Almost constant release rates were observed during the first 7h. ► Self-assembled nanoparticles exhibited antioxidant activity. ► Resulting nanoparticles enhanced Human Microvascular Endothelial Cells viability.
Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254–496nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40–75nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation. |
| doi_str_mv | 10.1016/j.carbpol.2012.10.005 |
| format | Article |
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Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254–496nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40–75nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2012.10.005</identifier><identifier>PMID: 23218376</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>alpha-Tocopherol - administration & dosage ; alpha-Tocopherol - chemistry ; Applied sciences ; aqueous solutions ; Biological and medical sciences ; cell proliferation ; chitosan ; Chitosan - administration & dosage ; Chitosan - analogs & derivatives ; Chitosan - chemical synthesis ; Chitosan - chemistry ; Chitosan conjugates ; Controlled release ; differential scanning calorimetry ; drug abuse ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; drugs ; drying ; Exact sciences and technology ; Fourier transform infrared spectroscopy ; free radical scavengers ; General and cellular metabolism. Vitamins ; HeLa Cells - drug effects ; Humans ; Magnetic Resonance Spectroscopy ; MCF-7 Cells - drug effects ; Medical sciences ; Microscopy, Electron, Transmission ; nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Natural polymers ; nuclear magnetic resonance spectroscopy ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Self-assembled nanoparticles ; Spectroscopy, Fourier Transform Infrared ; Starch and polysaccharides ; Tocopherol ; transmission electron microscopy ; vitamin E ; Water - chemistry ; X-ray diffraction</subject><ispartof>Carbohydrate polymers, 2013-01, Vol.92 (1), p.856-864</ispartof><rights>2012 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-45ae8987fc54daefd1cd9dc0866712ef1c0db2a1288f84af69d78f1d20e34b033</citedby><cites>FETCH-LOGICAL-c419t-45ae8987fc54daefd1cd9dc0866712ef1c0db2a1288f84af69d78f1d20e34b033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0144861712010235$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26901012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23218376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quiñones, Javier Pérez</creatorcontrib><creatorcontrib>Gothelf, Kurt Vesterager</creatorcontrib><creatorcontrib>Kjems, Jørgen</creatorcontrib><creatorcontrib>Yang, Chuanxu</creatorcontrib><creatorcontrib>Caballero, Angeles María Heras</creatorcontrib><creatorcontrib>Schmidt, Claudia</creatorcontrib><creatorcontrib>Covas, Carlos Peniche</creatorcontrib><title>Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>► Vitamin E was linked to O6-succinylated chitosan and glycol chitosan. ► Resulting conjugates formed self-assembled nanoparticles in aqueous solution. ► Almost constant release rates were observed during the first 7h. ► Self-assembled nanoparticles exhibited antioxidant activity. ► Resulting nanoparticles enhanced Human Microvascular Endothelial Cells viability.
Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254–496nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40–75nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation.</description><subject>alpha-Tocopherol - administration & dosage</subject><subject>alpha-Tocopherol - chemistry</subject><subject>Applied sciences</subject><subject>aqueous solutions</subject><subject>Biological and medical sciences</subject><subject>cell proliferation</subject><subject>chitosan</subject><subject>Chitosan - administration & dosage</subject><subject>Chitosan - analogs & derivatives</subject><subject>Chitosan - chemical synthesis</subject><subject>Chitosan - chemistry</subject><subject>Chitosan conjugates</subject><subject>Controlled release</subject><subject>differential scanning calorimetry</subject><subject>drug abuse</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>drugs</subject><subject>drying</subject><subject>Exact sciences and technology</subject><subject>Fourier transform infrared spectroscopy</subject><subject>free radical scavengers</subject><subject>General and cellular metabolism. Vitamins</subject><subject>HeLa Cells - drug effects</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>MCF-7 Cells - drug effects</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Transmission</subject><subject>nanoparticles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Natural polymers</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Self-assembled nanoparticles</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Starch and polysaccharides</subject><subject>Tocopherol</subject><subject>transmission electron microscopy</subject><subject>vitamin E</subject><subject>Water - chemistry</subject><subject>X-ray diffraction</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EotvCIwC5IHHJYjuO45wQqvgnVeJQerYm9rjryImDnVTisXgRngmvdoEjvlgaf7-Z0WdCXjC6Z5TJt-PeQBqWGPacMl5qe0rbR2THVNfXrBHiMdlRJkStJOsuyGXOIy1HMvqUXPCGM9V0ckfGWwyuhpxxGgLaaoY5LpBWbwLmKrpqitY7j7Y2B7_GDHNl4jxu97CWdxdTtR6wyltewc8lnzAgZDwmbah__azXaOJywBTDM_LEQcj4_HxfkbuPH75df65vvn76cv3-pjaC9WstWkDVq86ZVlhAZ5mxvTVUSdkxjo4ZagcOjCvllAAne9spxyyn2IiBNs0VeXPqu6T4fcO86slngyHAjHHLmvGmoz1vO1XQ9oSaFHNO6PSS_ATph2ZUHzXrUZ8166PmY7loLrmX5xHbMKH9m_rjtQCvzwBkA8ElmI3P_zjZ09KeF-7ViXMQNdynwtzdlkmyfFXLhBSFeHcisCh78Jh0Nh5ng9YnNKu20f9n2d9LKamI</recordid><startdate>20130130</startdate><enddate>20130130</enddate><creator>Quiñones, Javier Pérez</creator><creator>Gothelf, Kurt Vesterager</creator><creator>Kjems, Jørgen</creator><creator>Yang, Chuanxu</creator><creator>Caballero, Angeles María Heras</creator><creator>Schmidt, Claudia</creator><creator>Covas, Carlos Peniche</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130130</creationdate><title>Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol</title><author>Quiñones, Javier Pérez ; Gothelf, Kurt Vesterager ; Kjems, Jørgen ; Yang, Chuanxu ; Caballero, Angeles María Heras ; Schmidt, Claudia ; Covas, Carlos Peniche</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-45ae8987fc54daefd1cd9dc0866712ef1c0db2a1288f84af69d78f1d20e34b033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>alpha-Tocopherol - administration & dosage</topic><topic>alpha-Tocopherol - chemistry</topic><topic>Applied sciences</topic><topic>aqueous solutions</topic><topic>Biological and medical sciences</topic><topic>cell proliferation</topic><topic>chitosan</topic><topic>Chitosan - administration & dosage</topic><topic>Chitosan - analogs & derivatives</topic><topic>Chitosan - chemical synthesis</topic><topic>Chitosan - chemistry</topic><topic>Chitosan conjugates</topic><topic>Controlled release</topic><topic>differential scanning calorimetry</topic><topic>drug abuse</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>drugs</topic><topic>drying</topic><topic>Exact sciences and technology</topic><topic>Fourier transform infrared spectroscopy</topic><topic>free radical scavengers</topic><topic>General and cellular metabolism. Vitamins</topic><topic>HeLa Cells - drug effects</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>MCF-7 Cells - drug effects</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Transmission</topic><topic>nanoparticles</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Natural polymers</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Self-assembled nanoparticles</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Starch and polysaccharides</topic><topic>Tocopherol</topic><topic>transmission electron microscopy</topic><topic>vitamin E</topic><topic>Water - chemistry</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quiñones, Javier Pérez</creatorcontrib><creatorcontrib>Gothelf, Kurt Vesterager</creatorcontrib><creatorcontrib>Kjems, Jørgen</creatorcontrib><creatorcontrib>Yang, Chuanxu</creatorcontrib><creatorcontrib>Caballero, Angeles María Heras</creatorcontrib><creatorcontrib>Schmidt, Claudia</creatorcontrib><creatorcontrib>Covas, Carlos Peniche</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quiñones, Javier Pérez</au><au>Gothelf, Kurt Vesterager</au><au>Kjems, Jørgen</au><au>Yang, Chuanxu</au><au>Caballero, Angeles María Heras</au><au>Schmidt, Claudia</au><au>Covas, Carlos Peniche</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2013-01-30</date><risdate>2013</risdate><volume>92</volume><issue>1</issue><spage>856</spage><epage>864</epage><pages>856-864</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>► Vitamin E was linked to O6-succinylated chitosan and glycol chitosan. ► Resulting conjugates formed self-assembled nanoparticles in aqueous solution. ► Almost constant release rates were observed during the first 7h. ► Self-assembled nanoparticles exhibited antioxidant activity. ► Resulting nanoparticles enhanced Human Microvascular Endothelial Cells viability.
Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254–496nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40–75nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23218376</pmid><doi>10.1016/j.carbpol.2012.10.005</doi><tpages>9</tpages></addata></record> |
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| subjects | alpha-Tocopherol - administration & dosage alpha-Tocopherol - chemistry Applied sciences aqueous solutions Biological and medical sciences cell proliferation chitosan Chitosan - administration & dosage Chitosan - analogs & derivatives Chitosan - chemical synthesis Chitosan - chemistry Chitosan conjugates Controlled release differential scanning calorimetry drug abuse Drug Carriers - administration & dosage Drug Carriers - chemistry drugs drying Exact sciences and technology Fourier transform infrared spectroscopy free radical scavengers General and cellular metabolism. Vitamins HeLa Cells - drug effects Humans Magnetic Resonance Spectroscopy MCF-7 Cells - drug effects Medical sciences Microscopy, Electron, Transmission nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Natural polymers nuclear magnetic resonance spectroscopy Pharmacology. Drug treatments Physicochemistry of polymers Self-assembled nanoparticles Spectroscopy, Fourier Transform Infrared Starch and polysaccharides Tocopherol transmission electron microscopy vitamin E Water - chemistry X-ray diffraction |
| title | Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol |
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