Male and Female Fertility Assessment in the Cynomolgus Monkey Following Administration of ABT-874, a Human Anti-IL-12/23p40 Monoclonal Antibody

BACKGROUND ABT‐874 is an anti‐IL‐12/23 monoclonal antibody that binds to the p40 subunit of human IL‐12 and IL‐23. As part of its preclinical safety assessment, studies were conducted to asses its potential effects on the reproductive system in male and female cynomolgus monkeys. METHODS Sexually ma...

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Veröffentlicht in:	Birth defects research. Part B. Developmental and reproductive toxicology 2012-12, Vol.95 (6), p.421-430
Hauptverfasser:	Enright, Brian P., Tornesi, Belen, Weinbauer, Gerhard F., Blaich, Guenter
Format:	Artikel
Sprache:	eng
Schlagworte:	ABT-874 Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - toxicity cynomolgus monkey Dose-Response Relationship, Drug Estradiol - blood Female fertility Fertility - drug effects Fertility - physiology Infertility - chemically induced Infertility - physiopathology Injections, Subcutaneous interleukin 12/23 Luteinizing Hormone - blood Macaca fascicularis - physiology Male Menstrual Cycle - drug effects Ovary - drug effects Ovary - metabolism Progesterone - blood Sperm Count Spermatozoa - drug effects Spermatozoa - physiology Testis - drug effects Testis - pathology Toxicity Tests
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