Mucoadhesive nanoparticles made of thiolated quaternary chitosan crosslinked with hyaluronan

► Thiolated quaternary chitosans were obtained from a chitosan of 32kDa MW. ► Nanoparticles were obtained by interaction of these polymers with hyaluronan. ► The nanoparticles were modispersed and showed mucoadhesivity. ► The nanoparticles were internalized by endothelial progenitor cells. ► The nan...

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Veröffentlicht in:	Carbohydrate polymers 2013-01, Vol.92 (1), p.33-39
Hauptverfasser:	Zambito, Ylenia, Felice, Francesca, Fabiano, Angela, Di Stefano, Rossella, Di Colo, Giacomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biological and medical sciences Cell Survival - drug effects cell viability Chitin - chemistry chitosan Chitosan - administration & dosage Chitosan - chemical synthesis Chitosan - chemistry Chitosan–hyaluronan nanoparticles crosslinking drugs Endothelial Cells - cytology Endothelial Cells - drug effects Exact sciences and technology freeze drying gastrointestinal system gelation General pharmacology Humans hyaluronic acid Hyaluronic Acid - administration & dosage Hyaluronic Acid - chemical synthesis Hyaluronic Acid - chemistry Ionotropically cross-linked nanoparticles Medical sciences Mucoadhesive nanoparticles mucosa Mucous Membrane - chemistry Nanoparticle cellular uptake nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Natural polymers oxidation Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers polymers Polymers - administration & dosage Polymers - chemical synthesis Polymers - chemistry Starch and polysaccharides stem cells Stem Cells - cytology Stem Cells - drug effects Surface Properties Thiolated quaternized chitosan thiols zeta potential
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