Pre- and Postnatal Development in the Cynomolgus Monkey Following Administration of ABT-874, a Human Anti-IL-12/23p40 Monoclonal Antibody

BACKGROUND ABT‐874 is an anti‐IL‐12/23 monoclonal antibody that binds to the p40 subunit of human IL‐12 and IL‐23. As part of its preclinical safety assessment, studies were conducted to assess its potential effects on pre‐ and postnatal development in cynomolgus monkeys. METHODS In the embryo‐fetal...

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Veröffentlicht in:	Birth defects research. Part B. Developmental and reproductive toxicology 2012-12, Vol.95 (6), p.431-443
Hauptverfasser:	Enright, Brian P., Tornesi, Belen, Weinbauer, Gerhard F., Blaich, Guenter
Format:	Artikel
Sprache:	eng
Schlagworte:	ABT-874 Animals Animals, Newborn Antibodies, Monoclonal - toxicity Antibody Formation - drug effects Body Weight - drug effects cynomolgus monkey Dose-Response Relationship, Drug embryo Embryo, Mammalian - drug effects Embryonic Development - drug effects Female Fetal Development - drug effects fetus Fetuses Hemocyanins - pharmacology Immune System - drug effects Injections, Subcutaneous interleukin 12/23 Lactation - drug effects Lymphocytes - drug effects Macaca fascicularis - physiology Male Maternal Exposure - adverse effects Medical research Monoclonal antibodies Pregnancy Prenatal Exposure Delayed Effects - chemically induced Toxicity Tests
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