Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses

► Galactosyl lactose and cellobiose can be successfully immobilized on gold substrates. ► Carbohydrate-binding lectins show specific affinities for the glyco-nanolayers. ► Human liver carcinoma cells adhere well to the hydrophilic glyco-scaffolds. ► Cytochrome P450 activity depends on the hybrid rat...

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Veröffentlicht in:	Carbohydrate polymers 2013-01, Vol.92 (1), p.374-379
Hauptverfasser:	Kitaoka, Takuya, Yoshiyama, Chiharu, Uemura, Fumi
Format:	Artikel
Sprache:	eng
Schlagworte:	adsorption bioactive properties Biointerface Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides cell culture Cell culture scaffold cellobiose Cellobiose - chemical synthesis Cellobiose - chemistry Chemistry cytochrome P-450 Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 activity Exact sciences and technology galactose Galactose - chemistry Galectins - chemistry Glycomaterial gold Gold - chemistry Hep G2 Cells hepatoma Humans Immobilization lactose Lactose - chemistry Lectin-binding assay lectins neoplasm cells Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Organic chemistry Preparations and properties quartz Self-assembled monolayer Semicarbazides - chemistry
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