Cachexia assessed by bioimpedance vector analysis as a prognostic indicator in chronic stable heart failure patients

Abstract Background This study explored whether the cachectic state assessed by bioimpedance vector analysis provides additional prognostic information about mortality from all causes. Methods We included 519 consecutive patients with stable chronic heart failure (mean age 62.5 ± 16.4 y; 286 males)....

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Veröffentlicht in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2012-09, Vol.28 (9), p.886-891
Hauptverfasser: Castillo-Martínez, Lilia, Ph.D, Colín-Ramírez, Eloisa, Ph.D, Orea-Tejeda, Arturo, M.D, González Islas, Dulce Gabriela, B.Ch.D, Rodríguez García, Wendy Daniella, B.Ch.D, Santillán Díaz, Cira, B.Ch.D, Gutiérrez Rodríguez, Ana Elizabeth, B.Ch.D, Vázquez Durán, Marisela, B.Ch.D, Keirns Davies, Candace, M.D
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container_end_page 891
container_issue 9
container_start_page 886
container_title Nutrition (Burbank, Los Angeles County, Calif.)
container_volume 28
creator Castillo-Martínez, Lilia, Ph.D
Colín-Ramírez, Eloisa, Ph.D
Orea-Tejeda, Arturo, M.D
González Islas, Dulce Gabriela, B.Ch.D
Rodríguez García, Wendy Daniella, B.Ch.D
Santillán Díaz, Cira, B.Ch.D
Gutiérrez Rodríguez, Ana Elizabeth, B.Ch.D
Vázquez Durán, Marisela, B.Ch.D
Keirns Davies, Candace, M.D
description Abstract Background This study explored whether the cachectic state assessed by bioimpedance vector analysis provides additional prognostic information about mortality from all causes. Methods We included 519 consecutive patients with stable chronic heart failure (mean age 62.5 ± 16.4 y; 286 males). Cachexia was identified in those subjects who fell outside the right lower quadrant of the reference curve of 95% on the resistance/reactance graph [bioelectrical impedance vectorial analysis (BIVA)-cachexia]. Clinical, anthropometric, and biochemical data were also evaluated. Results Patients with BIVA-cachexia ( n = 196, 37.8%) were older and had significantly lower ejection fraction, handgrip strength, serum albumin, total cholesterol, and triglycerides. The frequency of patients with body mass index < 20, decreased muscle strength, hypoalbuminemia, anemia, anorexia, New York Heart Association functional classes III/IV and edema, as well as creatinine levels, resistance/height, and impedance index was significantly higher in the cachexia group. During 29 ± 11 mo of follow-up, 39 (19.9%) patients with BIVA-cachexia and 38 (11.7%) patients without BIVA-cachexia ( P < 0.0001) died. Conclusions The cachectic state is an independent risk factor for mortality in chronic heart failure patients. BIVA could represent a valuable tool to assess presence of cachexia as changes in body cell mass in heart failure patients because provide information additional to weight loss.
doi_str_mv 10.1016/j.nut.2011.11.024
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Methods We included 519 consecutive patients with stable chronic heart failure (mean age 62.5 ± 16.4 y; 286 males). Cachexia was identified in those subjects who fell outside the right lower quadrant of the reference curve of 95% on the resistance/reactance graph [bioelectrical impedance vectorial analysis (BIVA)-cachexia]. Clinical, anthropometric, and biochemical data were also evaluated. Results Patients with BIVA-cachexia ( n = 196, 37.8%) were older and had significantly lower ejection fraction, handgrip strength, serum albumin, total cholesterol, and triglycerides. The frequency of patients with body mass index &lt; 20, decreased muscle strength, hypoalbuminemia, anemia, anorexia, New York Heart Association functional classes III/IV and edema, as well as creatinine levels, resistance/height, and impedance index was significantly higher in the cachexia group. During 29 ± 11 mo of follow-up, 39 (19.9%) patients with BIVA-cachexia and 38 (11.7%) patients without BIVA-cachexia ( P &lt; 0.0001) died. Conclusions The cachectic state is an independent risk factor for mortality in chronic heart failure patients. BIVA could represent a valuable tool to assess presence of cachexia as changes in body cell mass in heart failure patients because provide information additional to weight loss.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2011.11.024</identifier><identifier>PMID: 22480798</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Anemia ; Anorexia ; bioelectrical impedance ; Bioelectrical impedance vector analysis ; Biological and medical sciences ; Biomarkers - analysis ; Biomedical research ; Body Composition - physiology ; Body Height ; Body Mass Index ; Cachexia ; Cachexia - etiology ; Cachexia - mortality ; Cachexia - physiopathology ; cholesterol ; Chronic Disease ; Chronic illnesses ; Disease ; Eating disorders ; Edema ; Electric Impedance ; Feeding. Feeding behavior ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Hand Strength ; heart ; Heart failure ; Heart Failure - complications ; Heart Failure - mortality ; Heart Failure - physiopathology ; Humans ; Hypoalbuminemia ; Impedance ; Insulin Resistance ; Male ; males ; Methods ; Middle Aged ; Mortality ; muscle strength ; Nutritional Status - physiology ; patients ; Prevalence ; Risk Factors ; serum albumin ; Standard deviation ; Thinness ; triacylglycerols ; Variables ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; weight loss</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2012-09, Vol.28 (9), p.886-891</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. 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Methods We included 519 consecutive patients with stable chronic heart failure (mean age 62.5 ± 16.4 y; 286 males). Cachexia was identified in those subjects who fell outside the right lower quadrant of the reference curve of 95% on the resistance/reactance graph [bioelectrical impedance vectorial analysis (BIVA)-cachexia]. Clinical, anthropometric, and biochemical data were also evaluated. Results Patients with BIVA-cachexia ( n = 196, 37.8%) were older and had significantly lower ejection fraction, handgrip strength, serum albumin, total cholesterol, and triglycerides. The frequency of patients with body mass index &lt; 20, decreased muscle strength, hypoalbuminemia, anemia, anorexia, New York Heart Association functional classes III/IV and edema, as well as creatinine levels, resistance/height, and impedance index was significantly higher in the cachexia group. During 29 ± 11 mo of follow-up, 39 (19.9%) patients with BIVA-cachexia and 38 (11.7%) patients without BIVA-cachexia ( P &lt; 0.0001) died. Conclusions The cachectic state is an independent risk factor for mortality in chronic heart failure patients. BIVA could represent a valuable tool to assess presence of cachexia as changes in body cell mass in heart failure patients because provide information additional to weight loss.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Anemia</subject><subject>Anorexia</subject><subject>bioelectrical impedance</subject><subject>Bioelectrical impedance vector analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biomedical research</subject><subject>Body Composition - physiology</subject><subject>Body Height</subject><subject>Body Mass Index</subject><subject>Cachexia</subject><subject>Cachexia - etiology</subject><subject>Cachexia - mortality</subject><subject>Cachexia - physiopathology</subject><subject>cholesterol</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>Disease</subject><subject>Eating disorders</subject><subject>Edema</subject><subject>Electric Impedance</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Hand Strength</subject><subject>heart</subject><subject>Heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Hypoalbuminemia</subject><subject>Impedance</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>males</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>muscle strength</subject><subject>Nutritional Status - physiology</subject><subject>patients</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>serum albumin</subject><subject>Standard deviation</subject><subject>Thinness</subject><subject>triacylglycerols</subject><subject>Variables</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>weight loss</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt-L1DAQgIso3nr6B_iiARF82XWStmnDgSCLv-DAh_OewzSZ3mbttmvSHu5_79RdPbgHDQOB8E0mmW-y7LmElQSp325X_TSuFEi54gBVPMgWsq7ypVRF8TBbQG3M0gBUZ9mTlLYAII02j7MzpYoaKlMvsnGNbkM_AwpMiTi8aA6iCUPY7clj70jckhuHKLDH7pBCYlCg2Mfhph_SGJwIvQ8OZyT0wm3i0PNhGrHpSGwI4yhaDN0USexxDNSP6Wn2qMUu0bPTfp5df_zwbf15efn105f1-8ulK2szLhuo8oJA123uiVpVOkdgGlC-KhR4o9C3ZCpdUo7e61ZS7tqixFJ57g5V-Xn25ngvv_bHRGm0u5AcdR32NEzJSqXyWoJS5f9RyKXU0oBm9NU9dDtMkbvzm9JGF5WZa8sj5eKQUqTW7mPYYTwwZGd7dmvZnp3tWQ62xzkvTjdPzY7834w_uhh4fQIwOezayIJCuuO0qnWVS-ZeHrkWB4s3kZnrK65U8ARUWqn5ExdHgrj_t4GiTY7dOPIhsm_rh_DPh767l-26wNqx-04HSnf9sElZsFfzIM5zKCVAkfP6BRI-1kM</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Castillo-Martínez, Lilia, Ph.D</creator><creator>Colín-Ramírez, Eloisa, Ph.D</creator><creator>Orea-Tejeda, Arturo, M.D</creator><creator>González Islas, Dulce Gabriela, B.Ch.D</creator><creator>Rodríguez García, Wendy Daniella, B.Ch.D</creator><creator>Santillán Díaz, Cira, B.Ch.D</creator><creator>Gutiérrez Rodríguez, Ana Elizabeth, B.Ch.D</creator><creator>Vázquez Durán, Marisela, B.Ch.D</creator><creator>Keirns Davies, Candace, M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Cachexia assessed by bioimpedance vector analysis as a prognostic indicator in chronic stable heart failure patients</title><author>Castillo-Martínez, Lilia, Ph.D ; Colín-Ramírez, Eloisa, Ph.D ; Orea-Tejeda, Arturo, M.D ; González Islas, Dulce Gabriela, B.Ch.D ; Rodríguez García, Wendy Daniella, B.Ch.D ; Santillán Díaz, Cira, B.Ch.D ; Gutiérrez Rodríguez, Ana Elizabeth, B.Ch.D ; Vázquez Durán, Marisela, B.Ch.D ; Keirns Davies, Candace, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-b0734e068f3deef25cce09b02d7420d92adfe9765e3add6f1e3cf45a52d016e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Anemia</topic><topic>Anorexia</topic><topic>bioelectrical impedance</topic><topic>Bioelectrical impedance vector analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biomedical research</topic><topic>Body Composition - physiology</topic><topic>Body Height</topic><topic>Body Mass Index</topic><topic>Cachexia</topic><topic>Cachexia - etiology</topic><topic>Cachexia - mortality</topic><topic>Cachexia - physiopathology</topic><topic>cholesterol</topic><topic>Chronic Disease</topic><topic>Chronic illnesses</topic><topic>Disease</topic><topic>Eating disorders</topic><topic>Edema</topic><topic>Electric Impedance</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Hand Strength</topic><topic>heart</topic><topic>Heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Hypoalbuminemia</topic><topic>Impedance</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>males</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>muscle strength</topic><topic>Nutritional Status - physiology</topic><topic>patients</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>serum albumin</topic><topic>Standard deviation</topic><topic>Thinness</topic><topic>triacylglycerols</topic><topic>Variables</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castillo-Martínez, Lilia, Ph.D</creatorcontrib><creatorcontrib>Colín-Ramírez, Eloisa, Ph.D</creatorcontrib><creatorcontrib>Orea-Tejeda, Arturo, M.D</creatorcontrib><creatorcontrib>González Islas, Dulce Gabriela, B.Ch.D</creatorcontrib><creatorcontrib>Rodríguez García, Wendy Daniella, B.Ch.D</creatorcontrib><creatorcontrib>Santillán Díaz, Cira, B.Ch.D</creatorcontrib><creatorcontrib>Gutiérrez Rodríguez, Ana Elizabeth, B.Ch.D</creatorcontrib><creatorcontrib>Vázquez Durán, Marisela, B.Ch.D</creatorcontrib><creatorcontrib>Keirns Davies, Candace, M.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career &amp; 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Methods We included 519 consecutive patients with stable chronic heart failure (mean age 62.5 ± 16.4 y; 286 males). Cachexia was identified in those subjects who fell outside the right lower quadrant of the reference curve of 95% on the resistance/reactance graph [bioelectrical impedance vectorial analysis (BIVA)-cachexia]. Clinical, anthropometric, and biochemical data were also evaluated. Results Patients with BIVA-cachexia ( n = 196, 37.8%) were older and had significantly lower ejection fraction, handgrip strength, serum albumin, total cholesterol, and triglycerides. The frequency of patients with body mass index &lt; 20, decreased muscle strength, hypoalbuminemia, anemia, anorexia, New York Heart Association functional classes III/IV and edema, as well as creatinine levels, resistance/height, and impedance index was significantly higher in the cachexia group. During 29 ± 11 mo of follow-up, 39 (19.9%) patients with BIVA-cachexia and 38 (11.7%) patients without BIVA-cachexia ( P &lt; 0.0001) died. Conclusions The cachectic state is an independent risk factor for mortality in chronic heart failure patients. BIVA could represent a valuable tool to assess presence of cachexia as changes in body cell mass in heart failure patients because provide information additional to weight loss.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22480798</pmid><doi>10.1016/j.nut.2011.11.024</doi><tpages>6</tpages></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland
subjects Age Factors
Aged
Anemia
Anorexia
bioelectrical impedance
Bioelectrical impedance vector analysis
Biological and medical sciences
Biomarkers - analysis
Biomedical research
Body Composition - physiology
Body Height
Body Mass Index
Cachexia
Cachexia - etiology
Cachexia - mortality
Cachexia - physiopathology
cholesterol
Chronic Disease
Chronic illnesses
Disease
Eating disorders
Edema
Electric Impedance
Feeding. Feeding behavior
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Hand Strength
heart
Heart failure
Heart Failure - complications
Heart Failure - mortality
Heart Failure - physiopathology
Humans
Hypoalbuminemia
Impedance
Insulin Resistance
Male
males
Methods
Middle Aged
Mortality
muscle strength
Nutritional Status - physiology
patients
Prevalence
Risk Factors
serum albumin
Standard deviation
Thinness
triacylglycerols
Variables
Vertebrates: anatomy and physiology, studies on body, several organs or systems
weight loss
title Cachexia assessed by bioimpedance vector analysis as a prognostic indicator in chronic stable heart failure patients
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