Myeloproliferative disorders "Philadelphia negative" and JAK2V617F mutation: study of 15 cases in Togo
The goal of our study is to document the prevalence of change JAK2V617F among patients reached of myeloproliferative syndromes (MPS) in Togo in order to evaluate frequencies. This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was ca...
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| Veröffentlicht in: | Annales de biologie clinique (Paris) 2012-10, Vol.70 (5), p.591-594 |
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| creator | Padaro, Essohana Agbetiafa, Kossi Delagnon Kueviakoe, Irénée Messanh Layibo, Yao Amegbor, Koffi Vovor, Ahoefa Giraudier, Stéphane Sanogo, Ibrahima Segbena, Akueté Yvon |
| description | The goal of our study is to document the prevalence of change JAK2V617F among patients reached of myeloproliferative syndromes (MPS) in Togo in order to evaluate frequencies. This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was carried out with the APHP Henri Mondor of Creteil (France). During the study period, 15 patients followed for MPS (9 cases of polycythemia Vera, 5 cases of essential thrombocytemia and a case of primitive myelofibrosis) profited from the research of JAK2 change. The Middle age of the patients was respectively of 45±18 years; of 55±6 years for the PV and the essential thrombocytemia. The patient followed for primitive myelofibrosis was 72 years old. Sex-ratio (H/F) was of 2. JAK2 Change was positive in 5 cases out of 9 (55.5%) of the polycythemia Vera, at 3 patients out of 5 (60%) followed for essential thrombocytemia but negative for patient reached of primitive myelofibrosis. In conclusion, JAK2 Change has an interest diagnosis and forecast in the MPS negative Chromosom Philadelphia and can be systematic even in Africa Sub-saharian. |
| doi_str_mv | 10.1684/abc.2012.0747 |
| format | Article |
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This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was carried out with the APHP Henri Mondor of Creteil (France). During the study period, 15 patients followed for MPS (9 cases of polycythemia Vera, 5 cases of essential thrombocytemia and a case of primitive myelofibrosis) profited from the research of JAK2 change. The Middle age of the patients was respectively of 45±18 years; of 55±6 years for the PV and the essential thrombocytemia. The patient followed for primitive myelofibrosis was 72 years old. Sex-ratio (H/F) was of 2. JAK2 Change was positive in 5 cases out of 9 (55.5%) of the polycythemia Vera, at 3 patients out of 5 (60%) followed for essential thrombocytemia but negative for patient reached of primitive myelofibrosis. In conclusion, JAK2 Change has an interest diagnosis and forecast in the MPS negative Chromosom Philadelphia and can be systematic even in Africa Sub-saharian.</description><identifier>EISSN: 1950-6112</identifier><identifier>DOI: 10.1684/abc.2012.0747</identifier><identifier>PMID: 23047905</identifier><language>fre</language><publisher>France</publisher><subject>Adult ; Aged ; Amino Acid Substitution - physiology ; Cohort Studies ; Female ; Humans ; Janus Kinase 2 - genetics ; Longitudinal Studies ; Male ; Middle Aged ; Mutation, Missense - physiology ; Myeloproliferative Disorders - diagnosis ; Myeloproliferative Disorders - epidemiology ; Myeloproliferative Disorders - genetics ; Phenylalanine - genetics ; Philadelphia Chromosome ; Prognosis ; Togo - epidemiology ; Valine - genetics</subject><ispartof>Annales de biologie clinique (Paris), 2012-10, Vol.70 (5), p.591-594</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23047905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Padaro, Essohana</creatorcontrib><creatorcontrib>Agbetiafa, Kossi</creatorcontrib><creatorcontrib>Delagnon Kueviakoe, Irénée Messanh</creatorcontrib><creatorcontrib>Layibo, Yao</creatorcontrib><creatorcontrib>Amegbor, Koffi</creatorcontrib><creatorcontrib>Vovor, Ahoefa</creatorcontrib><creatorcontrib>Giraudier, Stéphane</creatorcontrib><creatorcontrib>Sanogo, Ibrahima</creatorcontrib><creatorcontrib>Segbena, Akueté Yvon</creatorcontrib><title>Myeloproliferative disorders "Philadelphia negative" and JAK2V617F mutation: study of 15 cases in Togo</title><title>Annales de biologie clinique (Paris)</title><addtitle>Ann Biol Clin (Paris)</addtitle><description>The goal of our study is to document the prevalence of change JAK2V617F among patients reached of myeloproliferative syndromes (MPS) in Togo in order to evaluate frequencies. This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was carried out with the APHP Henri Mondor of Creteil (France). During the study period, 15 patients followed for MPS (9 cases of polycythemia Vera, 5 cases of essential thrombocytemia and a case of primitive myelofibrosis) profited from the research of JAK2 change. The Middle age of the patients was respectively of 45±18 years; of 55±6 years for the PV and the essential thrombocytemia. The patient followed for primitive myelofibrosis was 72 years old. Sex-ratio (H/F) was of 2. JAK2 Change was positive in 5 cases out of 9 (55.5%) of the polycythemia Vera, at 3 patients out of 5 (60%) followed for essential thrombocytemia but negative for patient reached of primitive myelofibrosis. In conclusion, JAK2 Change has an interest diagnosis and forecast in the MPS negative Chromosom Philadelphia and can be systematic even in Africa Sub-saharian.</description><subject>Adult</subject><subject>Aged</subject><subject>Amino Acid Substitution - physiology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Janus Kinase 2 - genetics</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation, Missense - physiology</subject><subject>Myeloproliferative Disorders - diagnosis</subject><subject>Myeloproliferative Disorders - epidemiology</subject><subject>Myeloproliferative Disorders - genetics</subject><subject>Phenylalanine - genetics</subject><subject>Philadelphia Chromosome</subject><subject>Prognosis</subject><subject>Togo - epidemiology</subject><subject>Valine - genetics</subject><issn>1950-6112</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kD1PwzAYhC0kREthZEVWJ5YUf8VO2CpE-SqCobBGjv26NUriECdI_fdEUKaT7h6ddIfQBSULKjNxrUuzYISyBVFCHaEpzVOSSErZBJ3G-EnGKOP8BE0YJ0LlJJ0i97KHKrRdqLyDTvf-G7D1MXQWuojnbztfaQtVu_MaN7D9BeZYNxY_LZ_Zh6RqheuhH_3Q3ODYD3aPg8M0xUZHiNg3eBO24QwdO11FOD_oDL2v7ja3D8n69f7xdrlOWiponzgtTC4dyVKplDQiM5zkwqRAJJWOC6DWMseVK5nIKTdCWkcNGKEgl6a0fIau_nrHRV8DxL6ofTRQVbqBMMSCMsYFy9M0G9HLAzqUNdii7Xytu33x_w3_AZdbYzY</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Padaro, Essohana</creator><creator>Agbetiafa, Kossi</creator><creator>Delagnon Kueviakoe, Irénée Messanh</creator><creator>Layibo, Yao</creator><creator>Amegbor, Koffi</creator><creator>Vovor, Ahoefa</creator><creator>Giraudier, Stéphane</creator><creator>Sanogo, Ibrahima</creator><creator>Segbena, Akueté Yvon</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Myeloproliferative disorders "Philadelphia negative" and JAK2V617F mutation: study of 15 cases in Togo</title><author>Padaro, Essohana ; Agbetiafa, Kossi ; Delagnon Kueviakoe, Irénée Messanh ; Layibo, Yao ; Amegbor, Koffi ; Vovor, Ahoefa ; Giraudier, Stéphane ; Sanogo, Ibrahima ; Segbena, Akueté Yvon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-fa4c96f0856776c48c3094c5e0616f34e1dd2f37fb24913c46df1cec47e96cbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amino Acid Substitution - physiology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Janus Kinase 2 - genetics</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation, Missense - physiology</topic><topic>Myeloproliferative Disorders - diagnosis</topic><topic>Myeloproliferative Disorders - epidemiology</topic><topic>Myeloproliferative Disorders - genetics</topic><topic>Phenylalanine - genetics</topic><topic>Philadelphia Chromosome</topic><topic>Prognosis</topic><topic>Togo - epidemiology</topic><topic>Valine - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Padaro, Essohana</creatorcontrib><creatorcontrib>Agbetiafa, Kossi</creatorcontrib><creatorcontrib>Delagnon Kueviakoe, Irénée Messanh</creatorcontrib><creatorcontrib>Layibo, Yao</creatorcontrib><creatorcontrib>Amegbor, Koffi</creatorcontrib><creatorcontrib>Vovor, Ahoefa</creatorcontrib><creatorcontrib>Giraudier, Stéphane</creatorcontrib><creatorcontrib>Sanogo, Ibrahima</creatorcontrib><creatorcontrib>Segbena, Akueté Yvon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annales de biologie clinique (Paris)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Padaro, Essohana</au><au>Agbetiafa, Kossi</au><au>Delagnon Kueviakoe, Irénée Messanh</au><au>Layibo, Yao</au><au>Amegbor, Koffi</au><au>Vovor, Ahoefa</au><au>Giraudier, Stéphane</au><au>Sanogo, Ibrahima</au><au>Segbena, Akueté Yvon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myeloproliferative disorders "Philadelphia negative" and JAK2V617F mutation: study of 15 cases in Togo</atitle><jtitle>Annales de biologie clinique (Paris)</jtitle><addtitle>Ann Biol Clin (Paris)</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>70</volume><issue>5</issue><spage>591</spage><epage>594</epage><pages>591-594</pages><eissn>1950-6112</eissn><abstract>The goal of our study is to document the prevalence of change JAK2V617F among patients reached of myeloproliferative syndromes (MPS) in Togo in order to evaluate frequencies. This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was carried out with the APHP Henri Mondor of Creteil (France). During the study period, 15 patients followed for MPS (9 cases of polycythemia Vera, 5 cases of essential thrombocytemia and a case of primitive myelofibrosis) profited from the research of JAK2 change. The Middle age of the patients was respectively of 45±18 years; of 55±6 years for the PV and the essential thrombocytemia. The patient followed for primitive myelofibrosis was 72 years old. Sex-ratio (H/F) was of 2. JAK2 Change was positive in 5 cases out of 9 (55.5%) of the polycythemia Vera, at 3 patients out of 5 (60%) followed for essential thrombocytemia but negative for patient reached of primitive myelofibrosis. In conclusion, JAK2 Change has an interest diagnosis and forecast in the MPS negative Chromosom Philadelphia and can be systematic even in Africa Sub-saharian.</abstract><cop>France</cop><pmid>23047905</pmid><doi>10.1684/abc.2012.0747</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Amino Acid Substitution - physiology Cohort Studies Female Humans Janus Kinase 2 - genetics Longitudinal Studies Male Middle Aged Mutation, Missense - physiology Myeloproliferative Disorders - diagnosis Myeloproliferative Disorders - epidemiology Myeloproliferative Disorders - genetics Phenylalanine - genetics Philadelphia Chromosome Prognosis Togo - epidemiology Valine - genetics |
| title | Myeloproliferative disorders "Philadelphia negative" and JAK2V617F mutation: study of 15 cases in Togo |
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