Pathological Effects in Lymphoid Tissues of the Spleen, Lymph Nodes, and Peyer’s Patches in Cyclosporin-Treated Cynomolgus Monkeys

Germinal center/lymphoid follicle area ratio and CD3/CD20-positive area ratio were calculated for the spleen, submandibular and mesenteric lymph nodes, and Peyer’s patches in cynomolgus monkeys treated orally with cyclosporin A (CsA), an immunosuppressant which blocks Ca2+/NFAT signaling. A differen...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2012, Vol.74(11), pp.1487-1491
Hauptverfasser:	MORIYAMA, Akiko, MAEDA, Hiroshi, HIRAI, Takuya, YAMAGUCHI, Ryoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antigens, CD20 - metabolism Calcium Signaling - drug effects CD3 Complex - metabolism cyclosporin Cyclosporine - administration & dosage Cyclosporine - pharmacology cynomolgus monkey Dose-Response Relationship, Drug Female Germinal Center - cytology Immunohistochemistry immunosuppression Lymph Nodes - cytology Lymph Nodes - drug effects Macaca fascicularis - immunology Male Peyer's Patches - cytology Peyer's Patches - drug effects Spleen - cytology Spleen - drug effects
Online-Zugang:	Volltext
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