Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera

The impact of inserting hydrocarbon staples into short α-helical antimicrobial peptides lasioglossin III and melectin (antimicrobial peptides of wild bee venom) on their biological and biophysical properties has been examined. The stapling was achieved by ring-closing olefin metathesis, either betwe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Amino acids 2012-11, Vol.43 (5), p.2047-2058
Hauptverfasser:	Chapuis, Hubert, Slaninová, Jiřina, Bednárová, Lucie, Monincová, Lenka, Buděšínský, Miloš, Čeřovský, Václav
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Amino Acid Sequence Analytical Chemistry Animals Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - pharmacology Bacteria - drug effects Bacteria - growth & development Bee Venoms - chemistry Bees - chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences Candida albicans - drug effects Candida albicans - growth & development Chromatography, Reverse-Phase Circular Dichroism Erythrocytes - drug effects Hemolysis - drug effects Humans Hymenoptera Life Sciences Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Sequence Data Neurobiology Original Article Protein Structure, Secondary Proteolysis Proteomics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!