Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection
A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wav...
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| Veröffentlicht in: | Optics letters 2012-10, Vol.37 (19), p.3969-3971 |
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| container_issue | 19 |
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| container_title | Optics letters |
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| creator | Lin, Hsing-Ying Huang, Chen-Han Huang, Chia-Chi Liu, Yu-Chia Chau, Lai-Kwan |
| description | A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 ×10(-6) RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected. |
| doi_str_mv | 10.1364/OL.37.003969 |
| format | Article |
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The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 ×10(-6) RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.</description><identifier>ISSN: 0146-9592</identifier><identifier>EISSN: 1539-4794</identifier><identifier>DOI: 10.1364/OL.37.003969</identifier><identifier>PMID: 23027248</identifier><language>eng</language><publisher>United States</publisher><subject>Aminocaproates - chemistry ; Animals ; Cattle ; Detectors ; Fiber optics ; Illumination ; Metal Nanoparticles - chemistry ; Nanorods ; Optical Fibers ; Sensors ; Silver ; Silver - chemistry ; Streptavidin - chemistry ; Surface Plasmon Resonance - instrumentation ; Time division multiplexing ; Time Factors</subject><ispartof>Optics letters, 2012-10, Vol.37 (19), p.3969-3971</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-ac993b544cae9c2d19405a3d30c14d8bdff95e46a249cf88820f52364484a1853</citedby><cites>FETCH-LOGICAL-c324t-ac993b544cae9c2d19405a3d30c14d8bdff95e46a249cf88820f52364484a1853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3258,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23027248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Hsing-Ying</creatorcontrib><creatorcontrib>Huang, Chen-Han</creatorcontrib><creatorcontrib>Huang, Chia-Chi</creatorcontrib><creatorcontrib>Liu, Yu-Chia</creatorcontrib><creatorcontrib>Chau, Lai-Kwan</creatorcontrib><title>Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection</title><title>Optics letters</title><addtitle>Opt Lett</addtitle><description>A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 ×10(-6) RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.</description><subject>Aminocaproates - chemistry</subject><subject>Animals</subject><subject>Cattle</subject><subject>Detectors</subject><subject>Fiber optics</subject><subject>Illumination</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Nanorods</subject><subject>Optical Fibers</subject><subject>Sensors</subject><subject>Silver</subject><subject>Silver - chemistry</subject><subject>Streptavidin - chemistry</subject><subject>Surface Plasmon Resonance - instrumentation</subject><subject>Time division multiplexing</subject><subject>Time Factors</subject><issn>0146-9592</issn><issn>1539-4794</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LtPwzAQBnALgWgpbMzIIwMpfib2iCpeUlAXmIPjnMEoL2IX6H9PSgsr00mn333SfQidUjKnPBWXy3zOszkhXKd6D02p5DoRmRb7aEqoSBMtNZugoxDeCCFpxvkhmjBOWMaEmqLnh1UdfV8DHiB0rWktYOdLGJKuj97iAG3oBvzp4yuOvgFc-Q8ffNfiZnf45dsX7EbzszCtqddxZBDBxtEdowNn6gAnuzlDTzfXj4u7JF_e3i-u8sRyJmJirNa8lEJYA9qyimpBpOEVJ5aKSpWVc1qCSA0T2jqlFCNOsvF_oYShSvIZOt_m9kP3voIQi8YHC3VtWuhWoaCMUU2ozNL_KVGMcUXYJvViS-3QhTCAK_rBN2ZYj6jY1F8s84Jnxbb-kZ_tkldlA9Uf_u2bfwP46YC_</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Lin, Hsing-Ying</creator><creator>Huang, Chen-Han</creator><creator>Huang, Chia-Chi</creator><creator>Liu, Yu-Chia</creator><creator>Chau, Lai-Kwan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20121001</creationdate><title>Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection</title><author>Lin, Hsing-Ying ; Huang, Chen-Han ; Huang, Chia-Chi ; Liu, Yu-Chia ; Chau, Lai-Kwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-ac993b544cae9c2d19405a3d30c14d8bdff95e46a249cf88820f52364484a1853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aminocaproates - chemistry</topic><topic>Animals</topic><topic>Cattle</topic><topic>Detectors</topic><topic>Fiber optics</topic><topic>Illumination</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Nanorods</topic><topic>Optical Fibers</topic><topic>Sensors</topic><topic>Silver</topic><topic>Silver - chemistry</topic><topic>Streptavidin - chemistry</topic><topic>Surface Plasmon Resonance - instrumentation</topic><topic>Time division multiplexing</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Hsing-Ying</creatorcontrib><creatorcontrib>Huang, Chen-Han</creatorcontrib><creatorcontrib>Huang, Chia-Chi</creatorcontrib><creatorcontrib>Liu, Yu-Chia</creatorcontrib><creatorcontrib>Chau, Lai-Kwan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Optics letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Hsing-Ying</au><au>Huang, Chen-Han</au><au>Huang, Chia-Chi</au><au>Liu, Yu-Chia</au><au>Chau, Lai-Kwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection</atitle><jtitle>Optics letters</jtitle><addtitle>Opt Lett</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>37</volume><issue>19</issue><spage>3969</spage><epage>3971</epage><pages>3969-3971</pages><issn>0146-9592</issn><eissn>1539-4794</eissn><abstract>A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. 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| fulltext | fulltext |
| identifier | ISSN: 0146-9592 |
| ispartof | Optics letters, 2012-10, Vol.37 (19), p.3969-3971 |
| issn | 0146-9592 1539-4794 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1221901576 |
| source | MEDLINE; Optica Publishing Group Journals |
| subjects | Aminocaproates - chemistry Animals Cattle Detectors Fiber optics Illumination Metal Nanoparticles - chemistry Nanorods Optical Fibers Sensors Silver Silver - chemistry Streptavidin - chemistry Surface Plasmon Resonance - instrumentation Time division multiplexing Time Factors |
| title | Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection |
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