Ultrasound-assisted convection-enhanced delivery to the brain in vivo with a novel transducer cannula assembly: Laboratory investigation

In convection-enhanced delivery (CED), drugs are infused locally into tissue through a cannula inserted into the brain parenchyma to enhance drug penetration over diffusion strategies. The purpose of this study was to demonstrate the feasibility of ultrasound-assisted CED (UCED) in the rodent brain...

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Veröffentlicht in:	Journal of neurosurgery 2012-12, Vol.117 (6), p.1128-1140
Hauptverfasser:	LEWIS, George K, SCHULZ, Zachary R, PANNULLO, Susan C, SOUTHARD, Teresa L, OLBRICHT, William L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - metabolism Catheters Coloring Agents - administration & dosage Coloring Agents - pharmacokinetics Convection Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Electric Impedance Equipment Design Evans Blue - administration & dosage Evans Blue - pharmacokinetics Feasibility Studies Medical sciences Neurosurgery Rats Rats, Sprague-Dawley Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Distribution Ultrasonics
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