Adherence styles of schizophrenia patients identified by a latent class analysis of the Medication Adherence Rating Scale (MARS): A six-month follow-up study
Abstract The purpose of this study was to examine patients' response profiles to the Medication Adherence Rating Scale (MARS) and to evaluate the potential of response styles as predictors of the future course of psychotic disorders in terms of rehospitalisation and maintenance of medication. A...
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| Veröffentlicht in: | Psychiatry research 2012-12, Vol.200 (2), p.83-88 |
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| creator | Jaeger, Susanne Pfiffner, Carmen Weiser, Prisca Kilian, Reinhold Becker, Thomas Längle, Gerhard Eschweiler, Gerhard Wilhelm Croissant, Daniela Schepp, Wiltrud Steinert, Tilman |
| description | Abstract The purpose of this study was to examine patients' response profiles to the Medication Adherence Rating Scale (MARS) and to evaluate the potential of response styles as predictors of the future course of psychotic disorders in terms of rehospitalisation and maintenance of medication. A total of 371 psychiatric in-patients with schizophrenia or schizoaffective disorder who were taking part in a naturalistic long-term study completed a German version of the MARS. A Latent Class Analysis (LCA) was performed. Five latent classes of response styles could be identified: “moderately adherent”, “critical discontinuers”, “good compliers”, “careless and forgetful”, and “compliant sceptics”. Class membership was found to be related to the severity of symptoms, level of functioning, insight into illness, insight into necessity of treatment, treatment satisfaction and medication side effects. At a six-month follow-up appointment, significant differences between the classes persisted. Participants showing a “good compliers” response pattern had a significantly better prognosis in terms of rehospitalisation rate and maintenance of the original medication than “critical discontinuers”. Evaluation of the MARS by studying response profiles provides informative results that reach beyond the results obtained by an evaluation by scores. Patients can be classified into adherence groups that are of predictive value for long-term patient outcome. |
| doi_str_mv | 10.1016/j.psychres.2012.03.033 |
| format | Article |
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A total of 371 psychiatric in-patients with schizophrenia or schizoaffective disorder who were taking part in a naturalistic long-term study completed a German version of the MARS. A Latent Class Analysis (LCA) was performed. Five latent classes of response styles could be identified: “moderately adherent”, “critical discontinuers”, “good compliers”, “careless and forgetful”, and “compliant sceptics”. Class membership was found to be related to the severity of symptoms, level of functioning, insight into illness, insight into necessity of treatment, treatment satisfaction and medication side effects. At a six-month follow-up appointment, significant differences between the classes persisted. Participants showing a “good compliers” response pattern had a significantly better prognosis in terms of rehospitalisation rate and maintenance of the original medication than “critical discontinuers”. Evaluation of the MARS by studying response profiles provides informative results that reach beyond the results obtained by an evaluation by scores. Patients can be classified into adherence groups that are of predictive value for long-term patient outcome.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2012.03.033</identifier><identifier>PMID: 22534500</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - therapeutic use ; Antipsychotics ; Biological and medical sciences ; Compliance ; Female ; Follow-Up Studies ; Humans ; LCA ; Male ; Medical sciences ; Medication Adherence - psychology ; Neuropharmacology ; Patient Satisfaction ; Pharmacology. Drug treatments ; Psychiatry ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Psychoses ; Psychosis ; Schizophrenia ; Schizophrenia - drug therapy ; Schizophrenic Psychology ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>Psychiatry research, 2012-12, Vol.200 (2), p.83-88</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-214c23bacc7e985d12596fa0a9edfd29e58b409f0ea00d0621aa71e2f3dc1d0a3</citedby><cites>FETCH-LOGICAL-c453t-214c23bacc7e985d12596fa0a9edfd29e58b409f0ea00d0621aa71e2f3dc1d0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165178112001424$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26711512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22534500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaeger, Susanne</creatorcontrib><creatorcontrib>Pfiffner, Carmen</creatorcontrib><creatorcontrib>Weiser, Prisca</creatorcontrib><creatorcontrib>Kilian, Reinhold</creatorcontrib><creatorcontrib>Becker, Thomas</creatorcontrib><creatorcontrib>Längle, Gerhard</creatorcontrib><creatorcontrib>Eschweiler, Gerhard Wilhelm</creatorcontrib><creatorcontrib>Croissant, Daniela</creatorcontrib><creatorcontrib>Schepp, Wiltrud</creatorcontrib><creatorcontrib>Steinert, Tilman</creatorcontrib><title>Adherence styles of schizophrenia patients identified by a latent class analysis of the Medication Adherence Rating Scale (MARS): A six-month follow-up study</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract The purpose of this study was to examine patients' response profiles to the Medication Adherence Rating Scale (MARS) and to evaluate the potential of response styles as predictors of the future course of psychotic disorders in terms of rehospitalisation and maintenance of medication. A total of 371 psychiatric in-patients with schizophrenia or schizoaffective disorder who were taking part in a naturalistic long-term study completed a German version of the MARS. A Latent Class Analysis (LCA) was performed. Five latent classes of response styles could be identified: “moderately adherent”, “critical discontinuers”, “good compliers”, “careless and forgetful”, and “compliant sceptics”. Class membership was found to be related to the severity of symptoms, level of functioning, insight into illness, insight into necessity of treatment, treatment satisfaction and medication side effects. At a six-month follow-up appointment, significant differences between the classes persisted. Participants showing a “good compliers” response pattern had a significantly better prognosis in terms of rehospitalisation rate and maintenance of the original medication than “critical discontinuers”. Evaluation of the MARS by studying response profiles provides informative results that reach beyond the results obtained by an evaluation by scores. Patients can be classified into adherence groups that are of predictive value for long-term patient outcome.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Antipsychotics</subject><subject>Biological and medical sciences</subject><subject>Compliance</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>LCA</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medication Adherence - psychology</subject><subject>Neuropharmacology</subject><subject>Patient Satisfaction</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatry</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Psychoses</subject><subject>Psychosis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenic Psychology</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFktuKFDEQhoMo7jj6CktuhPWixxz66IU4LJ5gF2FHr0MmqXYyZjptqltt38V3Ne3MuuCNUFAQ_r-qUl8Rcs7ZijNePt-vepzMLgKuBONixWQKeY8seF2JrOJC3ieLJCwyXtX8jDxC3DPGBG-ah-RMiELmBWML8mttdxChM0BxmDwgDS1Fs3M_Q5-qd07TXg8OugGpsym51oGl24lq6vWQHqjxGpHqTvsJ3R__sAN6DdaZ5AwdvWtxkx66z3RjtAd6cb2-2Tx7QdcU3Y_sELphR9vgffiejX2aZrTTY_Kg1R7hySkvyac3rz9evsuuPrx9f7m-ykxeyCETPDdCbrUxFTR1YbkomrLVTDdgWysaKOptzpqWgWbMslJwrSsOopXWcMu0XJKLY90-hq8j4KAODg14rzsIIyouBK-LmskqScuj1MSAGKFVfXQHHSfFmZrRqL26RaNmNIrJFDIZz089xu0B7F_bLYskeHoSaEwLaqPujMM7XVlxXiSwS_LqqIO0kW8OokLj5vVaF8EMygb3_1le_lPCeNclXv4LTID7MMaEM_1bYfKozXxI8x1xwRjPRS5_A68Jx0w</recordid><startdate>20121230</startdate><enddate>20121230</enddate><creator>Jaeger, Susanne</creator><creator>Pfiffner, Carmen</creator><creator>Weiser, Prisca</creator><creator>Kilian, Reinhold</creator><creator>Becker, Thomas</creator><creator>Längle, Gerhard</creator><creator>Eschweiler, Gerhard Wilhelm</creator><creator>Croissant, Daniela</creator><creator>Schepp, Wiltrud</creator><creator>Steinert, Tilman</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121230</creationdate><title>Adherence styles of schizophrenia patients identified by a latent class analysis of the Medication Adherence Rating Scale (MARS): A six-month follow-up study</title><author>Jaeger, Susanne ; Pfiffner, Carmen ; Weiser, Prisca ; Kilian, Reinhold ; Becker, Thomas ; Längle, Gerhard ; Eschweiler, Gerhard Wilhelm ; Croissant, Daniela ; Schepp, Wiltrud ; Steinert, Tilman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-214c23bacc7e985d12596fa0a9edfd29e58b409f0ea00d0621aa71e2f3dc1d0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Antipsychotics</topic><topic>Biological and medical sciences</topic><topic>Compliance</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>LCA</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medication Adherence - psychology</topic><topic>Neuropharmacology</topic><topic>Patient Satisfaction</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatry</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Psychoses</topic><topic>Psychosis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenic Psychology</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaeger, Susanne</creatorcontrib><creatorcontrib>Pfiffner, Carmen</creatorcontrib><creatorcontrib>Weiser, Prisca</creatorcontrib><creatorcontrib>Kilian, Reinhold</creatorcontrib><creatorcontrib>Becker, Thomas</creatorcontrib><creatorcontrib>Längle, Gerhard</creatorcontrib><creatorcontrib>Eschweiler, Gerhard Wilhelm</creatorcontrib><creatorcontrib>Croissant, Daniela</creatorcontrib><creatorcontrib>Schepp, Wiltrud</creatorcontrib><creatorcontrib>Steinert, Tilman</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaeger, Susanne</au><au>Pfiffner, Carmen</au><au>Weiser, Prisca</au><au>Kilian, Reinhold</au><au>Becker, Thomas</au><au>Längle, Gerhard</au><au>Eschweiler, Gerhard Wilhelm</au><au>Croissant, Daniela</au><au>Schepp, Wiltrud</au><au>Steinert, Tilman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adherence styles of schizophrenia patients identified by a latent class analysis of the Medication Adherence Rating Scale (MARS): A six-month follow-up study</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2012-12-30</date><risdate>2012</risdate><volume>200</volume><issue>2</issue><spage>83</spage><epage>88</epage><pages>83-88</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract The purpose of this study was to examine patients' response profiles to the Medication Adherence Rating Scale (MARS) and to evaluate the potential of response styles as predictors of the future course of psychotic disorders in terms of rehospitalisation and maintenance of medication. A total of 371 psychiatric in-patients with schizophrenia or schizoaffective disorder who were taking part in a naturalistic long-term study completed a German version of the MARS. A Latent Class Analysis (LCA) was performed. Five latent classes of response styles could be identified: “moderately adherent”, “critical discontinuers”, “good compliers”, “careless and forgetful”, and “compliant sceptics”. Class membership was found to be related to the severity of symptoms, level of functioning, insight into illness, insight into necessity of treatment, treatment satisfaction and medication side effects. At a six-month follow-up appointment, significant differences between the classes persisted. Participants showing a “good compliers” response pattern had a significantly better prognosis in terms of rehospitalisation rate and maintenance of the original medication than “critical discontinuers”. Evaluation of the MARS by studying response profiles provides informative results that reach beyond the results obtained by an evaluation by scores. Patients can be classified into adherence groups that are of predictive value for long-term patient outcome.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>22534500</pmid><doi>10.1016/j.psychres.2012.03.033</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Antipsychotics Biological and medical sciences Compliance Female Follow-Up Studies Humans LCA Male Medical sciences Medication Adherence - psychology Neuropharmacology Patient Satisfaction Pharmacology. Drug treatments Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Psychosis Schizophrenia Schizophrenia - drug therapy Schizophrenic Psychology Severity of Illness Index Treatment Outcome |
| title | Adherence styles of schizophrenia patients identified by a latent class analysis of the Medication Adherence Rating Scale (MARS): A six-month follow-up study |
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