Psychiatric comorbidity in refractory focal epilepsy: A study of 490 patients
Abstract We studied the prevalence and associated factors of psychiatric comorbidities in 490 patients with refractory focal epilepsy. Of these, 198 (40.4%) patients had psychiatric comorbidity. An Axis I diagnosis was made in 154 patients (31.4%) and an Axis II diagnosis (personality disorder) in a...
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| Veröffentlicht in: | Epilepsy & behavior 2012-12, Vol.25 (4), p.593-597 |
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| creator | Dalmagro, Charles L Velasco, Tonicarlo R Bianchin, Marino M Martins, Ana Paula P Guarnieri, Ricardo Cescato, Maria P Carlotti, Carlos G Assirati, João A Araújo, David Santos, Antonio C Hallak, Jaime E Sakamoto, Américo C |
| description | Abstract We studied the prevalence and associated factors of psychiatric comorbidities in 490 patients with refractory focal epilepsy. Of these, 198 (40.4%) patients had psychiatric comorbidity. An Axis I diagnosis was made in 154 patients (31.4%) and an Axis II diagnosis (personality disorder) in another 44 (8.97%) patients. After logistic regression, positive family history of psychiatric comorbidities (O.R. = 1.98; 95% CI = 1.10–3.58; p = 0.023), the presence of Axis II psychiatric comorbidities (O.R. = 3.25; 95% CI = 1.70–6.22; p < 0.0001), and the epileptogenic zone located in mesial temporal lobe structures (O.R. = 1.94; 95% CI = 1.25–3.03; p = 0.003) remained associated with Axis I psychiatric comorbidities. We concluded that a combination of clinical variables and selected structural abnormalities of the central nervous system contributes to the development of psychiatric comorbidities in patients with focal epilepsy. |
| doi_str_mv | 10.1016/j.yebeh.2012.09.026 |
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Of these, 198 (40.4%) patients had psychiatric comorbidity. An Axis I diagnosis was made in 154 patients (31.4%) and an Axis II diagnosis (personality disorder) in another 44 (8.97%) patients. After logistic regression, positive family history of psychiatric comorbidities (O.R. = 1.98; 95% CI = 1.10–3.58; p = 0.023), the presence of Axis II psychiatric comorbidities (O.R. = 3.25; 95% CI = 1.70–6.22; p < 0.0001), and the epileptogenic zone located in mesial temporal lobe structures (O.R. = 1.94; 95% CI = 1.25–3.03; p = 0.003) remained associated with Axis I psychiatric comorbidities. We concluded that a combination of clinical variables and selected structural abnormalities of the central nervous system contributes to the development of psychiatric comorbidities in patients with focal epilepsy.</description><identifier>ISSN: 1525-5050</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2012.09.026</identifier><identifier>PMID: 23159384</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Anxiety Disorders - epidemiology ; Chi-Square Distribution ; Comorbidity ; Epilepsies, Partial - epidemiology ; Female ; Frontal lobe epilepsy ; Humans ; Limbic system ; Logistic Models ; Male ; Mental Disorders - epidemiology ; Middle Aged ; Mood Disorders - epidemiology ; Neocortical epilepsy ; Neurology ; Personality Disorders - epidemiology ; Psychiatric comorbidities ; Psychotic Disorders - epidemiology ; Statistics, Nonparametric ; Temporal lobe epilepsy ; Young Adult</subject><ispartof>Epilepsy & behavior, 2012-12, Vol.25 (4), p.593-597</ispartof><rights>2012</rights><rights>Copyright © 2012. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-b33b7abf2072a88632003b2b039d73d96ae778e9cc67992e1dd1dde18ea21c973</citedby><cites>FETCH-LOGICAL-c414t-b33b7abf2072a88632003b2b039d73d96ae778e9cc67992e1dd1dde18ea21c973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yebeh.2012.09.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23159384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dalmagro, Charles L</creatorcontrib><creatorcontrib>Velasco, Tonicarlo R</creatorcontrib><creatorcontrib>Bianchin, Marino M</creatorcontrib><creatorcontrib>Martins, Ana Paula P</creatorcontrib><creatorcontrib>Guarnieri, Ricardo</creatorcontrib><creatorcontrib>Cescato, Maria P</creatorcontrib><creatorcontrib>Carlotti, Carlos G</creatorcontrib><creatorcontrib>Assirati, João A</creatorcontrib><creatorcontrib>Araújo, David</creatorcontrib><creatorcontrib>Santos, Antonio C</creatorcontrib><creatorcontrib>Hallak, Jaime E</creatorcontrib><creatorcontrib>Sakamoto, Américo C</creatorcontrib><title>Psychiatric comorbidity in refractory focal epilepsy: A study of 490 patients</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description>Abstract We studied the prevalence and associated factors of psychiatric comorbidities in 490 patients with refractory focal epilepsy. Of these, 198 (40.4%) patients had psychiatric comorbidity. An Axis I diagnosis was made in 154 patients (31.4%) and an Axis II diagnosis (personality disorder) in another 44 (8.97%) patients. After logistic regression, positive family history of psychiatric comorbidities (O.R. = 1.98; 95% CI = 1.10–3.58; p = 0.023), the presence of Axis II psychiatric comorbidities (O.R. = 3.25; 95% CI = 1.70–6.22; p < 0.0001), and the epileptogenic zone located in mesial temporal lobe structures (O.R. = 1.94; 95% CI = 1.25–3.03; p = 0.003) remained associated with Axis I psychiatric comorbidities. We concluded that a combination of clinical variables and selected structural abnormalities of the central nervous system contributes to the development of psychiatric comorbidities in patients with focal epilepsy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Chi-Square Distribution</subject><subject>Comorbidity</subject><subject>Epilepsies, Partial - epidemiology</subject><subject>Female</subject><subject>Frontal lobe epilepsy</subject><subject>Humans</subject><subject>Limbic system</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mental Disorders - epidemiology</subject><subject>Middle Aged</subject><subject>Mood Disorders - epidemiology</subject><subject>Neocortical epilepsy</subject><subject>Neurology</subject><subject>Personality Disorders - epidemiology</subject><subject>Psychiatric comorbidities</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Statistics, Nonparametric</subject><subject>Temporal lobe epilepsy</subject><subject>Young Adult</subject><issn>1525-5050</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVoSdK0v6BQdOxlXY1k2VYghRD6BSkNtD0LWRoTbbyWK8kB__tou0kOvRQGZg7vOx_PEPIWWAUMmg_basUebyvOgFdMVYw3R-QUJJcbyRr14rmW7IS8SmnLGIAUcExOuACpRFefku83abW33uToLbVhF2Lvnc8r9RONOERjc4grHYI1I8XZjzin9Zxe0pQXt9Iw0FoxOpvsccrpNXk5mDHhm8d8Rn5__vTr6uvm-seXb1eX1xtbQ503vRB9a_qBs5abrmsEZ0z0vGdCuVY41Rhs2w6VtU2rFEdwrgRCh4aDVa04I-8PfecY_iyYst75ZHEczYRhSRo4h07KtmZFKg5SG0NK5SQ9R78zcdXA9J6j3uq_HPWeo2ZKF47F9e5xwNLv0D17nsAVwcVBgOXMe49RJ1sQWHQ-os3aBf-fAR__8dvRT75QvsMV0zYscSoENehUPPrn_pX7T0JBJbuywANteZj2</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Dalmagro, Charles L</creator><creator>Velasco, Tonicarlo R</creator><creator>Bianchin, Marino M</creator><creator>Martins, Ana Paula P</creator><creator>Guarnieri, Ricardo</creator><creator>Cescato, Maria P</creator><creator>Carlotti, Carlos G</creator><creator>Assirati, João A</creator><creator>Araújo, David</creator><creator>Santos, Antonio C</creator><creator>Hallak, Jaime E</creator><creator>Sakamoto, Américo C</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Psychiatric comorbidity in refractory focal epilepsy: A study of 490 patients</title><author>Dalmagro, Charles L ; Velasco, Tonicarlo R ; Bianchin, Marino M ; Martins, Ana Paula P ; Guarnieri, Ricardo ; Cescato, Maria P ; Carlotti, Carlos G ; Assirati, João A ; Araújo, David ; Santos, Antonio C ; Hallak, Jaime E ; Sakamoto, Américo C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-b33b7abf2072a88632003b2b039d73d96ae778e9cc67992e1dd1dde18ea21c973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Chi-Square Distribution</topic><topic>Comorbidity</topic><topic>Epilepsies, Partial - epidemiology</topic><topic>Female</topic><topic>Frontal lobe epilepsy</topic><topic>Humans</topic><topic>Limbic system</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mental Disorders - epidemiology</topic><topic>Middle Aged</topic><topic>Mood Disorders - epidemiology</topic><topic>Neocortical epilepsy</topic><topic>Neurology</topic><topic>Personality Disorders - epidemiology</topic><topic>Psychiatric comorbidities</topic><topic>Psychotic Disorders - epidemiology</topic><topic>Statistics, Nonparametric</topic><topic>Temporal lobe epilepsy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dalmagro, Charles L</creatorcontrib><creatorcontrib>Velasco, Tonicarlo R</creatorcontrib><creatorcontrib>Bianchin, Marino M</creatorcontrib><creatorcontrib>Martins, Ana Paula P</creatorcontrib><creatorcontrib>Guarnieri, Ricardo</creatorcontrib><creatorcontrib>Cescato, Maria P</creatorcontrib><creatorcontrib>Carlotti, Carlos G</creatorcontrib><creatorcontrib>Assirati, João A</creatorcontrib><creatorcontrib>Araújo, David</creatorcontrib><creatorcontrib>Santos, Antonio C</creatorcontrib><creatorcontrib>Hallak, Jaime E</creatorcontrib><creatorcontrib>Sakamoto, Américo C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalmagro, Charles L</au><au>Velasco, Tonicarlo R</au><au>Bianchin, Marino M</au><au>Martins, Ana Paula P</au><au>Guarnieri, Ricardo</au><au>Cescato, Maria P</au><au>Carlotti, Carlos G</au><au>Assirati, João A</au><au>Araújo, David</au><au>Santos, Antonio C</au><au>Hallak, Jaime E</au><au>Sakamoto, Américo C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychiatric comorbidity in refractory focal epilepsy: A study of 490 patients</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>25</volume><issue>4</issue><spage>593</spage><epage>597</epage><pages>593-597</pages><issn>1525-5050</issn><eissn>1525-5069</eissn><abstract>Abstract We studied the prevalence and associated factors of psychiatric comorbidities in 490 patients with refractory focal epilepsy. Of these, 198 (40.4%) patients had psychiatric comorbidity. An Axis I diagnosis was made in 154 patients (31.4%) and an Axis II diagnosis (personality disorder) in another 44 (8.97%) patients. After logistic regression, positive family history of psychiatric comorbidities (O.R. = 1.98; 95% CI = 1.10–3.58; p = 0.023), the presence of Axis II psychiatric comorbidities (O.R. = 3.25; 95% CI = 1.70–6.22; p < 0.0001), and the epileptogenic zone located in mesial temporal lobe structures (O.R. = 1.94; 95% CI = 1.25–3.03; p = 0.003) remained associated with Axis I psychiatric comorbidities. We concluded that a combination of clinical variables and selected structural abnormalities of the central nervous system contributes to the development of psychiatric comorbidities in patients with focal epilepsy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23159384</pmid><doi>10.1016/j.yebeh.2012.09.026</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Anxiety Disorders - epidemiology Chi-Square Distribution Comorbidity Epilepsies, Partial - epidemiology Female Frontal lobe epilepsy Humans Limbic system Logistic Models Male Mental Disorders - epidemiology Middle Aged Mood Disorders - epidemiology Neocortical epilepsy Neurology Personality Disorders - epidemiology Psychiatric comorbidities Psychotic Disorders - epidemiology Statistics, Nonparametric Temporal lobe epilepsy Young Adult |
| title | Psychiatric comorbidity in refractory focal epilepsy: A study of 490 patients |
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