Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives
A new group of pyrimidine derivatives of indane-1,3-dione were synthesized aiming at the synthesis of new compounds acting as analgesic, anti-inflammatory and antimicrobial activity in a single component. The title compounds (3a-l) were synthesized from chalcone derivatives of indane-1,3-dione (2a-l...
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| Veröffentlicht in: | European journal of medicinal chemistry 2012-12, Vol.58, p.478-484 |
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| container_title | European journal of medicinal chemistry |
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| creator | Giles, D. Roopa, Karki Sheeba, F.R. Gurubasavarajaswamy, P.M. Divakar, Goli Vidhya, Thomas |
| description | A new group of pyrimidine derivatives of indane-1,3-dione were synthesized aiming at the synthesis of new compounds acting as analgesic, anti-inflammatory and antimicrobial activity in a single component. The title compounds (3a-l) were synthesized from chalcone derivatives of indane-1,3-dione (2a-l) through cyclization reaction with urea. The synthesized compounds were characterized by FT-IR, 1H NMR, mass spectral data, elemental analysis and evaluated for anti-inflammatory, analgesic, antibacterial and antifungal activities. The most active compound 3e, was evaluated for its ulcerogenicity. Good anti-inflammatory property was observed for chlorophenyl substituted pyrimidine derivatives. It mainly binds with Pro 218 of 1CX2, and the ligand could have caused much conformational changes in the protein structure than other derivatives. It also exhibits good analgesic and antimicrobial agent in a single component.
Pyrimidine derivatives of indane-1,3-dione were synthesized and evaluated for its anti-inflammatory, analgesic and antimicrobial activity in a single component. Chloro phenyl substituted derivative showed promising activity in a single component. [Display omitted]
► We studied the modification of pyrimidine in 4-position. ► We examine analgesic, anti-inflammatory and antimicrobial activity. ► We compared docking results with anti-inflammatory activity. ► Chloro substituted derivatives showed good pharmacological activity. |
| doi_str_mv | 10.1016/j.ejmech.2012.09.050 |
| format | Article |
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Pyrimidine derivatives of indane-1,3-dione were synthesized and evaluated for its anti-inflammatory, analgesic and antimicrobial activity in a single component. Chloro phenyl substituted derivative showed promising activity in a single component. [Display omitted]
► We studied the modification of pyrimidine in 4-position. ► We examine analgesic, anti-inflammatory and antimicrobial activity. ► We compared docking results with anti-inflammatory activity. ► Chloro substituted derivatives showed good pharmacological activity.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2012.09.050</identifier><identifier>PMID: 23159805</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>Analgesic activity ; Analgesics - chemical synthesis ; Analgesics - chemistry ; Analgesics - pharmacology ; Animals ; Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Anti-Inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antifungal Agents - chemical synthesis ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Antimicrobial activity ; Aspergillus niger - drug effects ; Bacillus subtilis - drug effects ; Biological and medical sciences ; Candida albicans - drug effects ; Cyclooxygenase ; Dose-Response Relationship, Drug ; Edema - chemically induced ; Edema - drug therapy ; Escherichia coli - drug effects ; Female ; Indane-1,3-dione ; Male ; Medical sciences ; Mice ; Microbial Sensitivity Tests ; Miscellaneous ; Models, Molecular ; Molecular Structure ; Pain - chemically induced ; Pain - drug therapy ; Pharmacology. Drug treatments ; Pseudomonas aeruginosa - drug effects ; Pyrimidine ; Pyrimidines - chemical synthesis ; Pyrimidines - chemistry ; Pyrimidines - pharmacology ; Rats ; Rats, Wistar ; Staphylococcus aureus - drug effects ; Structure-Activity Relationship ; Ulcer - chemically induced ; Ulcer - drug therapy ; Ulcerogenic activity</subject><ispartof>European journal of medicinal chemistry, 2012-12, Vol.58, p.478-484</ispartof><rights>2012 Elsevier Masson SAS</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-cd4af1626d7b5200fac0009af61fc8b2f2052b089f1ffa6d3c2ba2ea028c80343</citedby><cites>FETCH-LOGICAL-c392t-cd4af1626d7b5200fac0009af61fc8b2f2052b089f1ffa6d3c2ba2ea028c80343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0223523412006022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26761933$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23159805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giles, D.</creatorcontrib><creatorcontrib>Roopa, Karki</creatorcontrib><creatorcontrib>Sheeba, F.R.</creatorcontrib><creatorcontrib>Gurubasavarajaswamy, P.M.</creatorcontrib><creatorcontrib>Divakar, Goli</creatorcontrib><creatorcontrib>Vidhya, Thomas</creatorcontrib><title>Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>A new group of pyrimidine derivatives of indane-1,3-dione were synthesized aiming at the synthesis of new compounds acting as analgesic, anti-inflammatory and antimicrobial activity in a single component. The title compounds (3a-l) were synthesized from chalcone derivatives of indane-1,3-dione (2a-l) through cyclization reaction with urea. The synthesized compounds were characterized by FT-IR, 1H NMR, mass spectral data, elemental analysis and evaluated for anti-inflammatory, analgesic, antibacterial and antifungal activities. The most active compound 3e, was evaluated for its ulcerogenicity. Good anti-inflammatory property was observed for chlorophenyl substituted pyrimidine derivatives. It mainly binds with Pro 218 of 1CX2, and the ligand could have caused much conformational changes in the protein structure than other derivatives. It also exhibits good analgesic and antimicrobial agent in a single component.
Pyrimidine derivatives of indane-1,3-dione were synthesized and evaluated for its anti-inflammatory, analgesic and antimicrobial activity in a single component. Chloro phenyl substituted derivative showed promising activity in a single component. [Display omitted]
► We studied the modification of pyrimidine in 4-position. ► We examine analgesic, anti-inflammatory and antimicrobial activity. ► We compared docking results with anti-inflammatory activity. ► Chloro substituted derivatives showed good pharmacological activity.</description><subject>Analgesic activity</subject><subject>Analgesics - chemical synthesis</subject><subject>Analgesics - chemistry</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antimicrobial activity</subject><subject>Aspergillus niger - drug effects</subject><subject>Bacillus subtilis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Candida albicans - drug effects</subject><subject>Cyclooxygenase</subject><subject>Dose-Response Relationship, Drug</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Escherichia coli - drug effects</subject><subject>Female</subject><subject>Indane-1,3-dione</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Miscellaneous</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Pain - chemically induced</subject><subject>Pain - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pyrimidine</subject><subject>Pyrimidines - chemical synthesis</subject><subject>Pyrimidines - chemistry</subject><subject>Pyrimidines - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Structure-Activity Relationship</subject><subject>Ulcer - chemically induced</subject><subject>Ulcer - drug therapy</subject><subject>Ulcerogenic activity</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAURS0EokPhHyCUDRKbpM_PsSfZIKGqUKRKlSisLcd-7njIx2AnI82_r0cz0B2rtzn3vqvD2HsOFQeurrYVbQeymwqBYwVtBRJesBVfq6YUKOuXbAWIopQo6gv2JqUtAEgF8JpdoOCybUCu2I-HwzhvKIVU7DYmDsZO_fQYrOkL2pt-MXOYxsKMrnCT_R3GxyLNiwuUiskXu0MMQ3BhpMJRDPsM7ym9Za-86RO9O99L9uvrzc_r2_Lu_tv36y93pRUtzqV1tfFcoXLrTiKANzYPbI1X3NumQ48gsYOm9dx7o5yw2BkkA9jYBkQtLtmnU-8uTn8WSrMeQrLU92akaUmaI_JG1nJ9ROsTauOUUiSvd3m5iQfNQR9t6q0-2dRHmxpanW3m2Ifzh6UbyP0L_dWXgY9nwKSszEcz2pCeObVWvBUic59PHGUf-0BRJxtotORCJDtrN4X_L3kCmtqV_w</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Giles, D.</creator><creator>Roopa, Karki</creator><creator>Sheeba, F.R.</creator><creator>Gurubasavarajaswamy, P.M.</creator><creator>Divakar, Goli</creator><creator>Vidhya, Thomas</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives</title><author>Giles, D. ; Roopa, Karki ; Sheeba, F.R. ; Gurubasavarajaswamy, P.M. ; Divakar, Goli ; Vidhya, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-cd4af1626d7b5200fac0009af61fc8b2f2052b089f1ffa6d3c2ba2ea028c80343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analgesic activity</topic><topic>Analgesics - chemical synthesis</topic><topic>Analgesics - chemistry</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antimicrobial activity</topic><topic>Aspergillus niger - drug effects</topic><topic>Bacillus subtilis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Candida albicans - drug effects</topic><topic>Cyclooxygenase</topic><topic>Dose-Response Relationship, Drug</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>Escherichia coli - drug effects</topic><topic>Female</topic><topic>Indane-1,3-dione</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Miscellaneous</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Pain - chemically induced</topic><topic>Pain - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pyrimidine</topic><topic>Pyrimidines - chemical synthesis</topic><topic>Pyrimidines - chemistry</topic><topic>Pyrimidines - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Structure-Activity Relationship</topic><topic>Ulcer - chemically induced</topic><topic>Ulcer - drug therapy</topic><topic>Ulcerogenic activity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giles, D.</creatorcontrib><creatorcontrib>Roopa, Karki</creatorcontrib><creatorcontrib>Sheeba, F.R.</creatorcontrib><creatorcontrib>Gurubasavarajaswamy, P.M.</creatorcontrib><creatorcontrib>Divakar, Goli</creatorcontrib><creatorcontrib>Vidhya, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giles, D.</au><au>Roopa, Karki</au><au>Sheeba, F.R.</au><au>Gurubasavarajaswamy, P.M.</au><au>Divakar, Goli</au><au>Vidhya, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>58</volume><spage>478</spage><epage>484</epage><pages>478-484</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>A new group of pyrimidine derivatives of indane-1,3-dione were synthesized aiming at the synthesis of new compounds acting as analgesic, anti-inflammatory and antimicrobial activity in a single component. The title compounds (3a-l) were synthesized from chalcone derivatives of indane-1,3-dione (2a-l) through cyclization reaction with urea. The synthesized compounds were characterized by FT-IR, 1H NMR, mass spectral data, elemental analysis and evaluated for anti-inflammatory, analgesic, antibacterial and antifungal activities. The most active compound 3e, was evaluated for its ulcerogenicity. Good anti-inflammatory property was observed for chlorophenyl substituted pyrimidine derivatives. It mainly binds with Pro 218 of 1CX2, and the ligand could have caused much conformational changes in the protein structure than other derivatives. It also exhibits good analgesic and antimicrobial agent in a single component.
Pyrimidine derivatives of indane-1,3-dione were synthesized and evaluated for its anti-inflammatory, analgesic and antimicrobial activity in a single component. Chloro phenyl substituted derivative showed promising activity in a single component. [Display omitted]
► We studied the modification of pyrimidine in 4-position. ► We examine analgesic, anti-inflammatory and antimicrobial activity. ► We compared docking results with anti-inflammatory activity. ► Chloro substituted derivatives showed good pharmacological activity.</abstract><cop>Kidlington</cop><pub>Elsevier Masson SAS</pub><pmid>23159805</pmid><doi>10.1016/j.ejmech.2012.09.050</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of medicinal chemistry, 2012-12, Vol.58, p.478-484 |
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| language | eng |
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| subjects | Analgesic activity Analgesics - chemical synthesis Analgesics - chemistry Analgesics - pharmacology Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antimicrobial activity Aspergillus niger - drug effects Bacillus subtilis - drug effects Biological and medical sciences Candida albicans - drug effects Cyclooxygenase Dose-Response Relationship, Drug Edema - chemically induced Edema - drug therapy Escherichia coli - drug effects Female Indane-1,3-dione Male Medical sciences Mice Microbial Sensitivity Tests Miscellaneous Models, Molecular Molecular Structure Pain - chemically induced Pain - drug therapy Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Pyrimidine Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Rats Rats, Wistar Staphylococcus aureus - drug effects Structure-Activity Relationship Ulcer - chemically induced Ulcer - drug therapy Ulcerogenic activity |
| title | Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives |
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