Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase

Endothelin-1 (ET-1) has been implicated in the development of pulmonary fibrosis, based on its capacity in vitro to promote extracellular matrix (ECM) production and contraction, and on studies showing elevated expression of ET-1 and its receptors in patients with pulmonary fibrosis. However, the in...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2012-12, Vol.47 (6), p.834-842
Hauptverfasser:	Lagares, David, Busnadiego, Oscar, García-Fernández, Rosa Ana, Lamas, Santiago, Rodríguez-Pascual, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals B-Lymphocytes - immunology B-Lymphocytes - pathology Cell Differentiation Cells, Cultured Endothelin-1 - biosynthesis Endothelin-1 - genetics Enzyme Activation Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - metabolism Genetic Vectors Humans Indoles - pharmacology Lung - immunology Lung - metabolism Lung - pathology Mice Mice, Inbred C57BL Myofibroblasts - pathology Myofibroblasts - physiology Phosphorylation Protein Processing, Post-Translational Pulmonary Fibrosis - enzymology Pulmonary Fibrosis - immunology Pulmonary Fibrosis - pathology Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Scleroderma, Systemic - enzymology Scleroderma, Systemic - immunology Scleroderma, Systemic - pathology Sulfonamides - pharmacology T-Lymphocytes - immunology T-Lymphocytes - pathology
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