Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy
. Purpose: To prospectively study prognostic factors for normal‐tension glaucoma (NTG) under treatment with topical β‐blocker. Methods: One hundred and forty‐six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2012-08, Vol.90 (5), p.e337-e343 |
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| creator | Araie, Makoto Shirato, Shiroaki Yamazaki, Yoshio Matsumoto, Chota Kitazawa, Yoshiaki Ohashi, Yasuo |
| description | .
Purpose: To prospectively study prognostic factors for normal‐tension glaucoma (NTG) under treatment with topical β‐blocker.
Methods: One hundred and forty‐six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean spherical equivalent refraction of −3.5 (−8.0 to +2.0) dioptre were randomized to topical nipradilol or timolol and followed for 3 years. The Humphrey full threshold 30‐2 visual field test was performed every 6 months, and optic disc photographs were obtained every 12 months. Progression was defined as visual field progression, optic disc and/or peripapillary nerve fibre layer change, and factors relating to progression were evaluated using Cox proportional hazards models.
Results: IOP decreased by 1.0 mmHg over the 3‐year period, during which 35% showed progression according to the aforementioned criteria. Optic disc haemorrhage (hazard ratio [HR] 4.00, p |
| doi_str_mv | 10.1111/j.1755-3768.2012.02425.x |
| format | Article |
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Purpose: To prospectively study prognostic factors for normal‐tension glaucoma (NTG) under treatment with topical β‐blocker.
Methods: One hundred and forty‐six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean spherical equivalent refraction of −3.5 (−8.0 to +2.0) dioptre were randomized to topical nipradilol or timolol and followed for 3 years. The Humphrey full threshold 30‐2 visual field test was performed every 6 months, and optic disc photographs were obtained every 12 months. Progression was defined as visual field progression, optic disc and/or peripapillary nerve fibre layer change, and factors relating to progression were evaluated using Cox proportional hazards models.
Results: IOP decreased by 1.0 mmHg over the 3‐year period, during which 35% showed progression according to the aforementioned criteria. Optic disc haemorrhage (hazard ratio [HR] 4.00, p < 0.001) and less extent of myopia (per dioptre, HR 1.15, p = 0.013) were significant risk factors. When progression was defined by visual field progression only, less extent of myopia was again a significant risk factor (HR 1.17, p = 0.038).
Conclusion: Beside optic disc haemorrhage, less extent of myopia was a risk factor for progression in the current NTG population where most patients were mildly myopic and IOP during follow‐up averaged 13.2 mmHg under topical β‐blocker.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2012.02425.x</identifier><identifier>PMID: 22551324</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Disease Progression ; Double-Blind Method ; Female ; Humans ; Intraocular Pressure - drug effects ; Low Tension Glaucoma - diagnosis ; Low Tension Glaucoma - drug therapy ; Male ; Middle Aged ; Myopia ; Myopia - complications ; normal-tension glaucoma ; Ophthalmic Solutions ; optic disc ; Prognosis ; Propanolamines - therapeutic use ; Prospective Studies ; risk factor ; Risk Factors ; Timolol - therapeutic use ; Tonometry, Ocular ; Vision Disorders - complications ; visual field ; Visual Fields</subject><ispartof>Acta ophthalmologica (Oxford, England), 2012-08, Vol.90 (5), p.e337-e343</ispartof><rights>2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation</rights><rights>2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4575-c0c60613a2cc8672d336e65297598e6070f78fd3a325d35132f97495805019ae3</citedby><cites>FETCH-LOGICAL-c4575-c0c60613a2cc8672d336e65297598e6070f78fd3a325d35132f97495805019ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1755-3768.2012.02425.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1755-3768.2012.02425.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22551324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Araie, Makoto</creatorcontrib><creatorcontrib>Shirato, Shiroaki</creatorcontrib><creatorcontrib>Yamazaki, Yoshio</creatorcontrib><creatorcontrib>Matsumoto, Chota</creatorcontrib><creatorcontrib>Kitazawa, Yoshiaki</creatorcontrib><creatorcontrib>Ohashi, Yasuo</creatorcontrib><creatorcontrib>Nipradilol‐Timolol Study Group</creatorcontrib><creatorcontrib>for the Nipradilol‐Timolol Study Group</creatorcontrib><title>Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>.
Purpose: To prospectively study prognostic factors for normal‐tension glaucoma (NTG) under treatment with topical β‐blocker.
Methods: One hundred and forty‐six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean spherical equivalent refraction of −3.5 (−8.0 to +2.0) dioptre were randomized to topical nipradilol or timolol and followed for 3 years. The Humphrey full threshold 30‐2 visual field test was performed every 6 months, and optic disc photographs were obtained every 12 months. Progression was defined as visual field progression, optic disc and/or peripapillary nerve fibre layer change, and factors relating to progression were evaluated using Cox proportional hazards models.
Results: IOP decreased by 1.0 mmHg over the 3‐year period, during which 35% showed progression according to the aforementioned criteria. Optic disc haemorrhage (hazard ratio [HR] 4.00, p < 0.001) and less extent of myopia (per dioptre, HR 1.15, p = 0.013) were significant risk factors. When progression was defined by visual field progression only, less extent of myopia was again a significant risk factor (HR 1.17, p = 0.038).
Conclusion: Beside optic disc haemorrhage, less extent of myopia was a risk factor for progression in the current NTG population where most patients were mildly myopic and IOP during follow‐up averaged 13.2 mmHg under topical β‐blocker.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Disease Progression</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Intraocular Pressure - drug effects</subject><subject>Low Tension Glaucoma - diagnosis</subject><subject>Low Tension Glaucoma - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myopia</subject><subject>Myopia - complications</subject><subject>normal-tension glaucoma</subject><subject>Ophthalmic Solutions</subject><subject>optic disc</subject><subject>Prognosis</subject><subject>Propanolamines - therapeutic use</subject><subject>Prospective Studies</subject><subject>risk factor</subject><subject>Risk Factors</subject><subject>Timolol - therapeutic use</subject><subject>Tonometry, Ocular</subject><subject>Vision Disorders - complications</subject><subject>visual field</subject><subject>Visual Fields</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkclOwzAURS0EYij8AsqSTYKH2E4WLBBDC1RUTAKxsYzjlLRJXOxEtL_Fh_BNOLR0jTd-su997_oYgADBCPl1PIkQpzQknCURhghHEMeYRvMNsLu-2FzX9GUH7Dk3gZAhxuJtsIMxpYjgeBc83hduGuRSNca6IDc2mFkzttq5wtSByYPa2EqWYaPr35NxKVtlKhm0daZt8P0VvpVGTX1Zmdo079rK2WIfbOWydPpgtffA0-XF49kgHI76V2enw1DFlNNQQcV8JCKxUgnjOCOEaUZxymmaaAY5zHmSZ0QSTDPSBc5THqc0gRSiVGrSA0fLvj7zR6tdI6rCKV2WstamdQJhjBLqH8u8NFlKlTXOWZ2LmS0qaRcCQdExFRPR4RIdOtExFb9MxdxbD1dT2rdKZ2vjH0QvOFkKPotSL_7dWJyOHrrK-8Olv3CNnq_90k4F4_77xPNtX9xdp-fsZvAqMPkBI5-UWQ</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Araie, Makoto</creator><creator>Shirato, Shiroaki</creator><creator>Yamazaki, Yoshio</creator><creator>Matsumoto, Chota</creator><creator>Kitazawa, Yoshiaki</creator><creator>Ohashi, Yasuo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy</title><author>Araie, Makoto ; Shirato, Shiroaki ; Yamazaki, Yoshio ; Matsumoto, Chota ; Kitazawa, Yoshiaki ; Ohashi, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4575-c0c60613a2cc8672d336e65297598e6070f78fd3a325d35132f97495805019ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Disease Progression</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Intraocular Pressure - drug effects</topic><topic>Low Tension Glaucoma - diagnosis</topic><topic>Low Tension Glaucoma - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myopia</topic><topic>Myopia - complications</topic><topic>normal-tension glaucoma</topic><topic>Ophthalmic Solutions</topic><topic>optic disc</topic><topic>Prognosis</topic><topic>Propanolamines - therapeutic use</topic><topic>Prospective Studies</topic><topic>risk factor</topic><topic>Risk Factors</topic><topic>Timolol - therapeutic use</topic><topic>Tonometry, Ocular</topic><topic>Vision Disorders - complications</topic><topic>visual field</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araie, Makoto</creatorcontrib><creatorcontrib>Shirato, Shiroaki</creatorcontrib><creatorcontrib>Yamazaki, Yoshio</creatorcontrib><creatorcontrib>Matsumoto, Chota</creatorcontrib><creatorcontrib>Kitazawa, Yoshiaki</creatorcontrib><creatorcontrib>Ohashi, Yasuo</creatorcontrib><creatorcontrib>Nipradilol‐Timolol Study Group</creatorcontrib><creatorcontrib>for the Nipradilol‐Timolol Study Group</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araie, Makoto</au><au>Shirato, Shiroaki</au><au>Yamazaki, Yoshio</au><au>Matsumoto, Chota</au><au>Kitazawa, Yoshiaki</au><au>Ohashi, Yasuo</au><aucorp>Nipradilol‐Timolol Study Group</aucorp><aucorp>for the Nipradilol‐Timolol Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2012-08</date><risdate>2012</risdate><volume>90</volume><issue>5</issue><spage>e337</spage><epage>e343</epage><pages>e337-e343</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>.
Purpose: To prospectively study prognostic factors for normal‐tension glaucoma (NTG) under treatment with topical β‐blocker.
Methods: One hundred and forty‐six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean spherical equivalent refraction of −3.5 (−8.0 to +2.0) dioptre were randomized to topical nipradilol or timolol and followed for 3 years. The Humphrey full threshold 30‐2 visual field test was performed every 6 months, and optic disc photographs were obtained every 12 months. Progression was defined as visual field progression, optic disc and/or peripapillary nerve fibre layer change, and factors relating to progression were evaluated using Cox proportional hazards models.
Results: IOP decreased by 1.0 mmHg over the 3‐year period, during which 35% showed progression according to the aforementioned criteria. Optic disc haemorrhage (hazard ratio [HR] 4.00, p < 0.001) and less extent of myopia (per dioptre, HR 1.15, p = 0.013) were significant risk factors. When progression was defined by visual field progression only, less extent of myopia was again a significant risk factor (HR 1.17, p = 0.038).
Conclusion: Beside optic disc haemorrhage, less extent of myopia was a risk factor for progression in the current NTG population where most patients were mildly myopic and IOP during follow‐up averaged 13.2 mmHg under topical β‐blocker.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22551324</pmid><doi>10.1111/j.1755-3768.2012.02425.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic beta-Antagonists - therapeutic use Disease Progression Double-Blind Method Female Humans Intraocular Pressure - drug effects Low Tension Glaucoma - diagnosis Low Tension Glaucoma - drug therapy Male Middle Aged Myopia Myopia - complications normal-tension glaucoma Ophthalmic Solutions optic disc Prognosis Propanolamines - therapeutic use Prospective Studies risk factor Risk Factors Timolol - therapeutic use Tonometry, Ocular Vision Disorders - complications visual field Visual Fields |
| title | Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy |
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