Molecular and epidemiologic predictors of Staphylococcus aureus colonization site in a population with limited nosocomial exposure
Background The anterior naris has been considered the most consistent location of asymptomatic Staphylococcus aureus colonization. However, recent studies have shown that a substantial number of individuals, ranging from 7% to 32% of colonized individuals, are exclusive throat carriers. Most of thes...
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| Veröffentlicht in: | American journal of infection control 2012-12, Vol.40 (10), p.992-996 |
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| creator | Smith, Tara C., PhD Forshey, Brett M., PhD Hanson, Blake M., MS Wardyn, Shylo E., MS Moritz, Erin D., MS, PhD |
| description | Background The anterior naris has been considered the most consistent location of asymptomatic Staphylococcus aureus colonization. However, recent studies have shown that a substantial number of individuals, ranging from 7% to 32% of colonized individuals, are exclusive throat carriers. Most of these studies have been carried out in a health care setting, limiting their generalizability to nonhospitalized populations. Methods To evaluate anatomic carriage sites of S aureus in individuals outside of a health care setting, we combined the results of 2 cross-sectional studies conducted in Iowa. Results S aureus was carried by 103 of 340 individuals (30.3%), including 31 (30.1%) exclusive throat carriers, 44 (42.7%) exclusive nose carriers, and 28 (27.2%) colonized in both sites. Nonwhite race (adjusted odds ratio [OR], 4.91; 95% confidence interval [CI], 1.26-18.3) and younger age (≥30 years: OR, 0.23; 95% CI, 0.10-0.54) were associated with increased odds of exclusive throat carriage, whereas nonwhite race (OR, 5.14; 95% CI, 1.62-16.3) and spring or summer sampling season (OR, 2.62; 95% CI, 1.32-5.18) were associated with increased odds of exclusive nasal carriage. Conclusions These findings suggest that including a throat swab in addition to a nasal swab could play an important role in the success of surveillance programs, particularly among younger adults. |
| doi_str_mv | 10.1016/j.ajic.2011.11.017 |
| format | Article |
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However, recent studies have shown that a substantial number of individuals, ranging from 7% to 32% of colonized individuals, are exclusive throat carriers. Most of these studies have been carried out in a health care setting, limiting their generalizability to nonhospitalized populations. Methods To evaluate anatomic carriage sites of S aureus in individuals outside of a health care setting, we combined the results of 2 cross-sectional studies conducted in Iowa. Results S aureus was carried by 103 of 340 individuals (30.3%), including 31 (30.1%) exclusive throat carriers, 44 (42.7%) exclusive nose carriers, and 28 (27.2%) colonized in both sites. Nonwhite race (adjusted odds ratio [OR], 4.91; 95% confidence interval [CI], 1.26-18.3) and younger age (≥30 years: OR, 0.23; 95% CI, 0.10-0.54) were associated with increased odds of exclusive throat carriage, whereas nonwhite race (OR, 5.14; 95% CI, 1.62-16.3) and spring or summer sampling season (OR, 2.62; 95% CI, 1.32-5.18) were associated with increased odds of exclusive nasal carriage. Conclusions These findings suggest that including a throat swab in addition to a nasal swab could play an important role in the success of surveillance programs, particularly among younger adults.</description><identifier>ISSN: 0196-6553</identifier><identifier>EISSN: 1527-3296</identifier><identifier>DOI: 10.1016/j.ajic.2011.11.017</identifier><identifier>PMID: 22418604</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anatomic location ; Bacterial carriage ; Bacterial diseases ; Biological and medical sciences ; Body site ; Carrier State - diagnosis ; Carrier State - epidemiology ; Cross-Sectional Studies ; Epidemiology ; Epidemiology. Vaccinations ; Female ; General aspects ; Human bacterial diseases ; Human infectious diseases. Experimental studies and models ; Humans ; Infection Control ; Infectious Disease ; Infectious diseases ; Iowa - epidemiology ; Male ; Medical sciences ; Middle Aged ; Nose ; Nose - microbiology ; Nosocomial infections ; Pharynx - microbiology ; Risk Factors ; Staphylococcal Infections - diagnosis ; Staphylococcal Infections - epidemiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus - isolation & purification ; Staphylococcus infections ; Surveillance ; Throat ; Young Adult ; Young adults</subject><ispartof>American journal of infection control, 2012-12, Vol.40 (10), p.992-996</ispartof><rights>Association for Professionals in Infection Control and Epidemiology, Inc.</rights><rights>2012 Association for Professionals in Infection Control and Epidemiology, Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Mosby-Year Book, Inc. Dec 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-5877365c8b98ce022121845dd9e1b6825c708865ac26e1e720fce75181a517533</citedby><cites>FETCH-LOGICAL-c469t-5877365c8b98ce022121845dd9e1b6825c708865ac26e1e720fce75181a517533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196655311013216$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26756470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22418604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Tara C., PhD</creatorcontrib><creatorcontrib>Forshey, Brett M., PhD</creatorcontrib><creatorcontrib>Hanson, Blake M., MS</creatorcontrib><creatorcontrib>Wardyn, Shylo E., MS</creatorcontrib><creatorcontrib>Moritz, Erin D., MS, PhD</creatorcontrib><title>Molecular and epidemiologic predictors of Staphylococcus aureus colonization site in a population with limited nosocomial exposure</title><title>American journal of infection control</title><addtitle>Am J Infect Control</addtitle><description>Background The anterior naris has been considered the most consistent location of asymptomatic Staphylococcus aureus colonization. However, recent studies have shown that a substantial number of individuals, ranging from 7% to 32% of colonized individuals, are exclusive throat carriers. Most of these studies have been carried out in a health care setting, limiting their generalizability to nonhospitalized populations. Methods To evaluate anatomic carriage sites of S aureus in individuals outside of a health care setting, we combined the results of 2 cross-sectional studies conducted in Iowa. Results S aureus was carried by 103 of 340 individuals (30.3%), including 31 (30.1%) exclusive throat carriers, 44 (42.7%) exclusive nose carriers, and 28 (27.2%) colonized in both sites. Nonwhite race (adjusted odds ratio [OR], 4.91; 95% confidence interval [CI], 1.26-18.3) and younger age (≥30 years: OR, 0.23; 95% CI, 0.10-0.54) were associated with increased odds of exclusive throat carriage, whereas nonwhite race (OR, 5.14; 95% CI, 1.62-16.3) and spring or summer sampling season (OR, 2.62; 95% CI, 1.32-5.18) were associated with increased odds of exclusive nasal carriage. Conclusions These findings suggest that including a throat swab in addition to a nasal swab could play an important role in the success of surveillance programs, particularly among younger adults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anatomic location</subject><subject>Bacterial carriage</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Body site</subject><subject>Carrier State - diagnosis</subject><subject>Carrier State - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>Epidemiology. Vaccinations</subject><subject>Female</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Humans</subject><subject>Infection Control</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Iowa - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nose</subject><subject>Nose - microbiology</subject><subject>Nosocomial infections</subject><subject>Pharynx - microbiology</subject><subject>Risk Factors</subject><subject>Staphylococcal Infections - diagnosis</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus - isolation & purification</subject><subject>Staphylococcus infections</subject><subject>Surveillance</subject><subject>Throat</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0196-6553</issn><issn>1527-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt-L1DAQx4so3nr6D_ggARHupWsmbdIURJDj_AEnPpw-h-x01suaNjVp1fXRv9zUXT24B2FgIPnMdyb5TlE8Br4GDur5bm13DteCA6xzcGjuFCuQoikr0aq7xYpDq0olZXVSPEhpxzlvKyXvFydC1KAVr1fFr_fBE87eRmaHjtHoOupd8OGzQzZG6hxOISYWtuxqsuP13gcMiHNido6UE2Z2cD_t5MLAkpuIuYFZNoYxi_45_O6ma-Zdn-86NoSUBXpnPaMfY0hZ5GFxb2t9okfHfFp8en3x8fxtefnhzbvzV5cl1qqdSqmbJk-PetNqJC4ECNC17LqWYKO0kNhwrZW0KBQBNYJvkRoJGqyERlbVaXF20B1j-DpTmkzvEpL3dqAwJwNZUktoW5HRp7fQXZjjkKdbKFHptpZ1psSBwhhSirQ1Y3S9jXsD3CwOmZ1ZHDKLQyZHdigXPTlKz5ueun8lfy3JwLMjYBNav412QJduONVIVTc8cy8OHOU_--YomoSOBsyWRcLJdMH9f46Xt8rRu8Hljl9oT-nmvSYJw83VskvLKkEWrASo6jcwVsSg</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Smith, Tara C., PhD</creator><creator>Forshey, Brett M., PhD</creator><creator>Hanson, Blake M., MS</creator><creator>Wardyn, Shylo E., MS</creator><creator>Moritz, Erin D., MS, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Mosby-Year Book, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Molecular and epidemiologic predictors of Staphylococcus aureus colonization site in a population with limited nosocomial exposure</title><author>Smith, Tara C., PhD ; Forshey, Brett M., PhD ; Hanson, Blake M., MS ; Wardyn, Shylo E., MS ; Moritz, Erin D., MS, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-5877365c8b98ce022121845dd9e1b6825c708865ac26e1e720fce75181a517533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anatomic location</topic><topic>Bacterial carriage</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Body site</topic><topic>Carrier State - diagnosis</topic><topic>Carrier State - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Epidemiology</topic><topic>Epidemiology. Vaccinations</topic><topic>Female</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Humans</topic><topic>Infection Control</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Iowa - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nose</topic><topic>Nose - microbiology</topic><topic>Nosocomial infections</topic><topic>Pharynx - microbiology</topic><topic>Risk Factors</topic><topic>Staphylococcal Infections - diagnosis</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Staphylococcus aureus - isolation & purification</topic><topic>Staphylococcus infections</topic><topic>Surveillance</topic><topic>Throat</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Tara C., PhD</creatorcontrib><creatorcontrib>Forshey, Brett M., PhD</creatorcontrib><creatorcontrib>Hanson, Blake M., MS</creatorcontrib><creatorcontrib>Wardyn, Shylo E., MS</creatorcontrib><creatorcontrib>Moritz, Erin D., MS, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of infection control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Tara C., PhD</au><au>Forshey, Brett M., PhD</au><au>Hanson, Blake M., MS</au><au>Wardyn, Shylo E., MS</au><au>Moritz, Erin D., MS, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular and epidemiologic predictors of Staphylococcus aureus colonization site in a population with limited nosocomial exposure</atitle><jtitle>American journal of infection control</jtitle><addtitle>Am J Infect Control</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>40</volume><issue>10</issue><spage>992</spage><epage>996</epage><pages>992-996</pages><issn>0196-6553</issn><eissn>1527-3296</eissn><abstract>Background The anterior naris has been considered the most consistent location of asymptomatic Staphylococcus aureus colonization. However, recent studies have shown that a substantial number of individuals, ranging from 7% to 32% of colonized individuals, are exclusive throat carriers. Most of these studies have been carried out in a health care setting, limiting their generalizability to nonhospitalized populations. Methods To evaluate anatomic carriage sites of S aureus in individuals outside of a health care setting, we combined the results of 2 cross-sectional studies conducted in Iowa. Results S aureus was carried by 103 of 340 individuals (30.3%), including 31 (30.1%) exclusive throat carriers, 44 (42.7%) exclusive nose carriers, and 28 (27.2%) colonized in both sites. Nonwhite race (adjusted odds ratio [OR], 4.91; 95% confidence interval [CI], 1.26-18.3) and younger age (≥30 years: OR, 0.23; 95% CI, 0.10-0.54) were associated with increased odds of exclusive throat carriage, whereas nonwhite race (OR, 5.14; 95% CI, 1.62-16.3) and spring or summer sampling season (OR, 2.62; 95% CI, 1.32-5.18) were associated with increased odds of exclusive nasal carriage. Conclusions These findings suggest that including a throat swab in addition to a nasal swab could play an important role in the success of surveillance programs, particularly among younger adults.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22418604</pmid><doi>10.1016/j.ajic.2011.11.017</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anatomic location Bacterial carriage Bacterial diseases Biological and medical sciences Body site Carrier State - diagnosis Carrier State - epidemiology Cross-Sectional Studies Epidemiology Epidemiology. Vaccinations Female General aspects Human bacterial diseases Human infectious diseases. Experimental studies and models Humans Infection Control Infectious Disease Infectious diseases Iowa - epidemiology Male Medical sciences Middle Aged Nose Nose - microbiology Nosocomial infections Pharynx - microbiology Risk Factors Staphylococcal Infections - diagnosis Staphylococcal Infections - epidemiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus - isolation & purification Staphylococcus infections Surveillance Throat Young Adult Young adults |
| title | Molecular and epidemiologic predictors of Staphylococcus aureus colonization site in a population with limited nosocomial exposure |
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