Prenatal stress induces alterations in cerebellar nitric oxide that are correlated with deficits in spatial memory in rat’s offspring
► Prenatal stress induces a disarrangement in offspring’s cerebellum. ► We examine the role of cerebellar nitric oxide system in this model. ► We found changes in behavioral parameters. ► There was an increase in nitric oxide synthase. ► Alterations in nitric oxide might be related to an altered beh...
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| Veröffentlicht in: | Neurochemistry international 2012-12, Vol.61 (8), p.1294-1301 |
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| creator | Maur, Damián G. Romero, Carolina B. Burdet, Berenice Palumbo, María L. Zorrilla-Zubilete, María A. |
| description | ► Prenatal stress induces a disarrangement in offspring’s cerebellum. ► We examine the role of cerebellar nitric oxide system in this model. ► We found changes in behavioral parameters. ► There was an increase in nitric oxide synthase. ► Alterations in nitric oxide might be related to an altered behavioral outcome.
Prenatal stress (PS) has been linked to abnormal cognitive, behavioral and psychosocial outcomes in both animals and humans. Since PS has been shown to induce a cerebellar cytoarchitectural disarrangement and cerebellar abnormalities that have been linked to an impairment of behavioral functions, the aim of the present work was to investigate whether the exposure to PS in a period in which the cerebellum is still immature can induce behavioral deficits in the adult and whether this alterations are correlated with changes in nitric oxide (NO) and cellular oxidative mechanisms in offspring’s cerebellum. Our results show impairments in spatial memory and territory discrimination in PS adult rats. PS offspring also displayed alterations in cerebellar nitric oxide synthase (NOS) expression and activity. Moreover, a correlation between spatial memory deficits and the increase in NOS activity was found. The results found here may point to a role of cerebellar NO in the behavioral alterations induced by stress during early development stages. |
| doi_str_mv | 10.1016/j.neuint.2012.09.006 |
| format | Article |
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Prenatal stress (PS) has been linked to abnormal cognitive, behavioral and psychosocial outcomes in both animals and humans. Since PS has been shown to induce a cerebellar cytoarchitectural disarrangement and cerebellar abnormalities that have been linked to an impairment of behavioral functions, the aim of the present work was to investigate whether the exposure to PS in a period in which the cerebellum is still immature can induce behavioral deficits in the adult and whether this alterations are correlated with changes in nitric oxide (NO) and cellular oxidative mechanisms in offspring’s cerebellum. Our results show impairments in spatial memory and territory discrimination in PS adult rats. PS offspring also displayed alterations in cerebellar nitric oxide synthase (NOS) expression and activity. Moreover, a correlation between spatial memory deficits and the increase in NOS activity was found. The results found here may point to a role of cerebellar NO in the behavioral alterations induced by stress during early development stages.</description><identifier>ISSN: 0197-0186</identifier><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/j.neuint.2012.09.006</identifier><identifier>PMID: 23022609</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cerebellum ; Cerebellum - metabolism ; Exploratory behavior ; Exploratory Behavior - physiology ; Female ; Male ; Maze Learning - physiology ; Memory Disorders - etiology ; Memory Disorders - metabolism ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type I - biosynthesis ; Nitric Oxide Synthase Type I - genetics ; Oxidative Stress ; Pregnancy ; Pregnancy Complications - etiology ; Pregnancy Complications - physiopathology ; Prenatal Exposure Delayed Effects ; Prenatal stress ; Random Allocation ; Rats ; Rats, Wistar ; Real-Time Polymerase Chain Reaction ; Restraint, Physical - adverse effects ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Stress, Psychological - etiology ; Stress, Psychological - physiopathology</subject><ispartof>Neurochemistry international, 2012-12, Vol.61 (8), p.1294-1301</ispartof><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-29f971fb00f7c10afbbe7d552ba829c47e44ad3704d128ab7a1cf2b836c893e83</citedby><cites>FETCH-LOGICAL-c408t-29f971fb00f7c10afbbe7d552ba829c47e44ad3704d128ab7a1cf2b836c893e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuint.2012.09.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23022609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maur, Damián G.</creatorcontrib><creatorcontrib>Romero, Carolina B.</creatorcontrib><creatorcontrib>Burdet, Berenice</creatorcontrib><creatorcontrib>Palumbo, María L.</creatorcontrib><creatorcontrib>Zorrilla-Zubilete, María A.</creatorcontrib><title>Prenatal stress induces alterations in cerebellar nitric oxide that are correlated with deficits in spatial memory in rat’s offspring</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>► Prenatal stress induces a disarrangement in offspring’s cerebellum. ► We examine the role of cerebellar nitric oxide system in this model. ► We found changes in behavioral parameters. ► There was an increase in nitric oxide synthase. ► Alterations in nitric oxide might be related to an altered behavioral outcome.
Prenatal stress (PS) has been linked to abnormal cognitive, behavioral and psychosocial outcomes in both animals and humans. Since PS has been shown to induce a cerebellar cytoarchitectural disarrangement and cerebellar abnormalities that have been linked to an impairment of behavioral functions, the aim of the present work was to investigate whether the exposure to PS in a period in which the cerebellum is still immature can induce behavioral deficits in the adult and whether this alterations are correlated with changes in nitric oxide (NO) and cellular oxidative mechanisms in offspring’s cerebellum. Our results show impairments in spatial memory and territory discrimination in PS adult rats. PS offspring also displayed alterations in cerebellar nitric oxide synthase (NOS) expression and activity. Moreover, a correlation between spatial memory deficits and the increase in NOS activity was found. The results found here may point to a role of cerebellar NO in the behavioral alterations induced by stress during early development stages.</description><subject>Animals</subject><subject>Cerebellum</subject><subject>Cerebellum - metabolism</subject><subject>Exploratory behavior</subject><subject>Exploratory Behavior - physiology</subject><subject>Female</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - metabolism</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase Type I - biosynthesis</subject><subject>Nitric Oxide Synthase Type I - genetics</subject><subject>Oxidative Stress</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - etiology</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal stress</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Restraint, Physical - adverse effects</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Stress, Psychological - etiology</subject><subject>Stress, Psychological - physiopathology</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1TAQtRAVvRT-ACEv2SSMnYfjDRKqgCJVogtYW449pr5K7IvtQLtjxzfwe_0SEm5h2dVIo_OYM4eQFwxqBqx_va8DLj6UmgPjNcgaoH9EdmwQvJKiax-THTApKmBDf0qe5rwHACGhe0JOeQOc9yB35NdVwqCLnmguCXOmPtjFYKZ6Kph08TFsO2ow4YjTpBMNviRvaLzxFmm51oXqhNTElHDSBS394cs1tei88eUvOR9WodVixjmm222zKt_9_J1pdC4fkg9fn5ETp6eMz-_nGfny_t3n84vq8tOHj-dvLyvTwlAqLp0UzI0AThgG2o0jCtt1fNQDl6YV2LbaNgJay_igR6GZcXwcmt4MssGhOSOvjrqHFL8tmIuafTZbsIBxyYpxzoaOtZKt0PYINSnmnNCp9dJZp1vFQG0VqL06VqC2ChRItVaw0l7eOyzjjPY_6d_PV8CbIwDXnN89JpWNx2DQ-oSmKBv9ww5_ADwXngA</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Maur, Damián G.</creator><creator>Romero, Carolina B.</creator><creator>Burdet, Berenice</creator><creator>Palumbo, María L.</creator><creator>Zorrilla-Zubilete, María A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Prenatal stress induces alterations in cerebellar nitric oxide that are correlated with deficits in spatial memory in rat’s offspring</title><author>Maur, Damián G. ; Romero, Carolina B. ; Burdet, Berenice ; Palumbo, María L. ; Zorrilla-Zubilete, María A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-29f971fb00f7c10afbbe7d552ba829c47e44ad3704d128ab7a1cf2b836c893e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Cerebellum</topic><topic>Cerebellum - metabolism</topic><topic>Exploratory behavior</topic><topic>Exploratory Behavior - physiology</topic><topic>Female</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Memory Disorders - etiology</topic><topic>Memory Disorders - metabolism</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase Type I - biosynthesis</topic><topic>Nitric Oxide Synthase Type I - genetics</topic><topic>Oxidative Stress</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - etiology</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal stress</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Restraint, Physical - adverse effects</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Stress, Psychological - etiology</topic><topic>Stress, Psychological - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maur, Damián G.</creatorcontrib><creatorcontrib>Romero, Carolina B.</creatorcontrib><creatorcontrib>Burdet, Berenice</creatorcontrib><creatorcontrib>Palumbo, María L.</creatorcontrib><creatorcontrib>Zorrilla-Zubilete, María A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maur, Damián G.</au><au>Romero, Carolina B.</au><au>Burdet, Berenice</au><au>Palumbo, María L.</au><au>Zorrilla-Zubilete, María A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal stress induces alterations in cerebellar nitric oxide that are correlated with deficits in spatial memory in rat’s offspring</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>2012-12</date><risdate>2012</risdate><volume>61</volume><issue>8</issue><spage>1294</spage><epage>1301</epage><pages>1294-1301</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><abstract>► Prenatal stress induces a disarrangement in offspring’s cerebellum. ► We examine the role of cerebellar nitric oxide system in this model. ► We found changes in behavioral parameters. ► There was an increase in nitric oxide synthase. ► Alterations in nitric oxide might be related to an altered behavioral outcome.
Prenatal stress (PS) has been linked to abnormal cognitive, behavioral and psychosocial outcomes in both animals and humans. Since PS has been shown to induce a cerebellar cytoarchitectural disarrangement and cerebellar abnormalities that have been linked to an impairment of behavioral functions, the aim of the present work was to investigate whether the exposure to PS in a period in which the cerebellum is still immature can induce behavioral deficits in the adult and whether this alterations are correlated with changes in nitric oxide (NO) and cellular oxidative mechanisms in offspring’s cerebellum. Our results show impairments in spatial memory and territory discrimination in PS adult rats. PS offspring also displayed alterations in cerebellar nitric oxide synthase (NOS) expression and activity. Moreover, a correlation between spatial memory deficits and the increase in NOS activity was found. The results found here may point to a role of cerebellar NO in the behavioral alterations induced by stress during early development stages.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23022609</pmid><doi>10.1016/j.neuint.2012.09.006</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cerebellum Cerebellum - metabolism Exploratory behavior Exploratory Behavior - physiology Female Male Maze Learning - physiology Memory Disorders - etiology Memory Disorders - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type I - biosynthesis Nitric Oxide Synthase Type I - genetics Oxidative Stress Pregnancy Pregnancy Complications - etiology Pregnancy Complications - physiopathology Prenatal Exposure Delayed Effects Prenatal stress Random Allocation Rats Rats, Wistar Real-Time Polymerase Chain Reaction Restraint, Physical - adverse effects RNA, Messenger - biosynthesis RNA, Messenger - genetics Stress, Psychological - etiology Stress, Psychological - physiopathology |
| title | Prenatal stress induces alterations in cerebellar nitric oxide that are correlated with deficits in spatial memory in rat’s offspring |
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