Binding of Eu(III) to 1,2-hydroxypyridinone-modified peptide nucleic acids

Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu(III) as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu(III) exci...

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Veröffentlicht in:	Inorganic chemistry 2012-12, Vol.51 (23), p.12597-12599
Hauptverfasser:	de Leon, Arnie R, Olatunde, Abiola O, Morrow, Janet R, Achim, Catalina
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Europium - chemistry Ligands Luminescence Molecular Structure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Peptide Nucleic Acids - chemistry Pyridones - chemistry Spectrophotometry, Ultraviolet Transition Temperature
Online-Zugang:	Volltext
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