Binding of Eu(III) to 1,2-hydroxypyridinone-modified peptide nucleic acids
Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu(III) as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu(III) exci...
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| Veröffentlicht in: | Inorganic chemistry 2012-12, Vol.51 (23), p.12597-12599 |
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| container_end_page | 12599 |
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| container_issue | 23 |
| container_start_page | 12597 |
| container_title | Inorganic chemistry |
| container_volume | 51 |
| creator | de Leon, Arnie R Olatunde, Abiola O Morrow, Janet R Achim, Catalina |
| description | Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu(III) as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu(III) excitation spectra and luminescence lifetime data are consistent with Eu(III) bound to both 1,2 HOPO ligands in a PNA-HOPO duplex as the major species present in solution. |
| doi_str_mv | 10.1021/ic301790v |
| format | Article |
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| fulltext | fulltext |
| identifier | EISSN: 1520-510X |
| ispartof | Inorganic chemistry, 2012-12, Vol.51 (23), p.12597-12599 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Binding Sites Europium - chemistry Ligands Luminescence Molecular Structure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Peptide Nucleic Acids - chemistry Pyridones - chemistry Spectrophotometry, Ultraviolet Transition Temperature |
| title | Binding of Eu(III) to 1,2-hydroxypyridinone-modified peptide nucleic acids |
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