In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo
The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for the treatment of various parasitic diseases and collected after an ethnopharmacological inventory conducted in the Bolongo area, Bandundu province in DR Congo, was evaluated. De...
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| Veröffentlicht in: | Journal of ethnopharmacology 2012-05, Vol.141 (1), p.301-308 |
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| creator | Musuyu Muganza, D. Fruth, B.I. Nzunzu Lami, J. Mesia, G.K. Kambu, O.K. Tona, G.L. Cimanga Kanyanga, R. Cos, P. Maes, L. Apers, S. Pieters, L. |
| description | The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for the treatment of various parasitic diseases and collected after an ethnopharmacological inventory conducted in the Bolongo area, Bandundu province in DR Congo, was evaluated.
Decoctions were prepared, lyophilized and evaluated for in vitro antiprotozoal activity against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum, and the chloroquine- and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Cytotoxicity against MRC-5 cells was included to assess selectivity of activity.
Most of the tested extracts exhibited pronounced (IC50≤5μg/ml) or good (5 |
| doi_str_mv | 10.1016/j.jep.2012.02.035 |
| format | Article |
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Decoctions were prepared, lyophilized and evaluated for in vitro antiprotozoal activity against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum, and the chloroquine- and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Cytotoxicity against MRC-5 cells was included to assess selectivity of activity.
Most of the tested extracts exhibited pronounced (IC50≤5μg/ml) or good (5<IC50≤10μg/ml) antiprotozoal activity against one or more of the selected protozoa. A total of 19 plant extracts inhibited Trypanosoma b. brucei, especially the extract from Isolona hexaloba stem bark (IC50=1.95μg/ml, SI=16.5); 8 plant extracts were active against Trypanosoma cruzi, the extracts from Enanatia chlorantha stem bark and Quassia africana root bark being the most active with IC50 values of 1.87 and 1.88μg/ml, respectively (SI=3.0 and 3.3, respectively); 8 plant extracts showed activity against Leishmania infantum, with extracts from Napoleona vogelii stem bark and Quassia africana root bark as the most active with IC50 values of 5.66 and 5.04μg/ml (SI=11.3 and 1.2). Finally, 9 plant extracts inhibited Plasmodium falciparum K1 with the extracts from Quassia africana (root bark and stem bark) being the most active ones with IC50 values of 0.46 and 1.27μg/ml (SI=13.7 and 13.6). Extracts from Enantia chlorantha stem bark, Piptadeniastrum africanum stem bark and Quassia africana root bark were cytotoxic for MRC-5 cells (CC50<10μg/ml).
These results can partly support and justify the traditional use of some of these plant species for the treatment of parasitic diseases.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2012.02.035</identifier><identifier>PMID: 22394563</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Annickia ; Antimalarials - pharmacology ; Antiprotozoal activity ; Antiprotozoal Agents - isolation & purification ; Antiprotozoal Agents - pharmacology ; Antiprotozoal Agents - therapeutic use ; Antiprotozoal Agents - toxicity ; Aqueous extracts ; bark ; Cell Line ; Cell Survival - drug effects ; Cytotoxicity ; Democratic Republic of the Congo ; Dose-Response Relationship, Drug ; DR Congo ; Ethnopharmacology ; Humans ; Inhibitory Concentration 50 ; inventories ; Isolona ; Leishmania infantum ; Leishmania infantum - drug effects ; Medicinal plants ; Medicine, African Traditional ; Parasitic Sensitivity Tests ; parasitoses ; Phytotherapy ; Piptadeniastrum ; plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; Plants, Medicinal ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Protozoa ; Quassia ; roots ; stems ; Trypanocidal Agents - pharmacology ; Trypanosoma brucei ; Trypanosoma brucei brucei - drug effects ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects</subject><ispartof>Journal of ethnopharmacology, 2012-05, Vol.141 (1), p.301-308</ispartof><rights>2012</rights><rights>Copyright © 2012. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-94cc080d8ccea8becdf99b63664c2a357b211d5110c94cb208ad38d7793970073</citedby><cites>FETCH-LOGICAL-c476t-94cc080d8ccea8becdf99b63664c2a357b211d5110c94cb208ad38d7793970073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2012.02.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22394563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Musuyu Muganza, D.</creatorcontrib><creatorcontrib>Fruth, B.I.</creatorcontrib><creatorcontrib>Nzunzu Lami, J.</creatorcontrib><creatorcontrib>Mesia, G.K.</creatorcontrib><creatorcontrib>Kambu, O.K.</creatorcontrib><creatorcontrib>Tona, G.L.</creatorcontrib><creatorcontrib>Cimanga Kanyanga, R.</creatorcontrib><creatorcontrib>Cos, P.</creatorcontrib><creatorcontrib>Maes, L.</creatorcontrib><creatorcontrib>Apers, S.</creatorcontrib><creatorcontrib>Pieters, L.</creatorcontrib><title>In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for the treatment of various parasitic diseases and collected after an ethnopharmacological inventory conducted in the Bolongo area, Bandundu province in DR Congo, was evaluated.
Decoctions were prepared, lyophilized and evaluated for in vitro antiprotozoal activity against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum, and the chloroquine- and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Cytotoxicity against MRC-5 cells was included to assess selectivity of activity.
Most of the tested extracts exhibited pronounced (IC50≤5μg/ml) or good (5<IC50≤10μg/ml) antiprotozoal activity against one or more of the selected protozoa. A total of 19 plant extracts inhibited Trypanosoma b. brucei, especially the extract from Isolona hexaloba stem bark (IC50=1.95μg/ml, SI=16.5); 8 plant extracts were active against Trypanosoma cruzi, the extracts from Enanatia chlorantha stem bark and Quassia africana root bark being the most active with IC50 values of 1.87 and 1.88μg/ml, respectively (SI=3.0 and 3.3, respectively); 8 plant extracts showed activity against Leishmania infantum, with extracts from Napoleona vogelii stem bark and Quassia africana root bark as the most active with IC50 values of 5.66 and 5.04μg/ml (SI=11.3 and 1.2). Finally, 9 plant extracts inhibited Plasmodium falciparum K1 with the extracts from Quassia africana (root bark and stem bark) being the most active ones with IC50 values of 0.46 and 1.27μg/ml (SI=13.7 and 13.6). Extracts from Enantia chlorantha stem bark, Piptadeniastrum africanum stem bark and Quassia africana root bark were cytotoxic for MRC-5 cells (CC50<10μg/ml).
These results can partly support and justify the traditional use of some of these plant species for the treatment of parasitic diseases.</description><subject>Annickia</subject><subject>Antimalarials - pharmacology</subject><subject>Antiprotozoal activity</subject><subject>Antiprotozoal Agents - isolation & purification</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Antiprotozoal Agents - therapeutic use</subject><subject>Antiprotozoal Agents - toxicity</subject><subject>Aqueous extracts</subject><subject>bark</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cytotoxicity</subject><subject>Democratic Republic of the Congo</subject><subject>Dose-Response Relationship, Drug</subject><subject>DR Congo</subject><subject>Ethnopharmacology</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>inventories</subject><subject>Isolona</subject><subject>Leishmania infantum</subject><subject>Leishmania infantum - drug effects</subject><subject>Medicinal plants</subject><subject>Medicine, African Traditional</subject><subject>Parasitic Sensitivity Tests</subject><subject>parasitoses</subject><subject>Phytotherapy</subject><subject>Piptadeniastrum</subject><subject>plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Extracts - toxicity</subject><subject>Plants, Medicinal</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Protozoa</subject><subject>Quassia</subject><subject>roots</subject><subject>stems</subject><subject>Trypanocidal Agents - pharmacology</subject><subject>Trypanosoma brucei</subject><subject>Trypanosoma brucei brucei - drug effects</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFuFCEUhomxsdvqA3ijXHozWxiYAeKVWa02aWKi9powZ5gtm5lhBLZxfYG-tqfZ6qVNSIDkOx-c8xPymrM1Z7y92K13flnXjNdrhks0z8iKa1VXqlHiOVkxoXSlleSn5CznHWNMcclekNO6FkY2rViR-6uZ3oWSInVzCUuKJf6ObsRbT-FQ8PorAHVQAlIHGgcqBPXlNs5xuXVpchDHuA3gxvFAsx89FN_TyfcBwoyeZURvpkOKE_3opwjJFRR-88u-G_GAwk2ct_ElORncmP2rx_2c3Fx--rH5Ul1__Xy1-XBdgVRtqYwEYJr1GsA73XnoB2O6VrSthNqJRnU1533DOQNEu5pp1wvdK2WEUdi-OCfvjl5s9efe52KnkMGP-E0f99nyGgWyUap9GmWMm1YyIxHlRxRSzDn5wS4pTC4dELIPUdmdxajsQ1SW4RIN1rx51O87nNe_ir_ZIPD2CAwuWrdNIdub72iQ-K7mxnAk3h8JjxO7Cz7ZDMHPgNNPGITtY_jPB_4AetGvOg</recordid><startdate>20120507</startdate><enddate>20120507</enddate><creator>Musuyu Muganza, D.</creator><creator>Fruth, B.I.</creator><creator>Nzunzu Lami, J.</creator><creator>Mesia, G.K.</creator><creator>Kambu, O.K.</creator><creator>Tona, G.L.</creator><creator>Cimanga Kanyanga, R.</creator><creator>Cos, P.</creator><creator>Maes, L.</creator><creator>Apers, S.</creator><creator>Pieters, L.</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20120507</creationdate><title>In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo</title><author>Musuyu Muganza, D. ; Fruth, B.I. ; Nzunzu Lami, J. ; Mesia, G.K. ; Kambu, O.K. ; Tona, G.L. ; Cimanga Kanyanga, R. ; Cos, P. ; Maes, L. ; Apers, S. ; Pieters, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-94cc080d8ccea8becdf99b63664c2a357b211d5110c94cb208ad38d7793970073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Annickia</topic><topic>Antimalarials - pharmacology</topic><topic>Antiprotozoal activity</topic><topic>Antiprotozoal Agents - isolation & purification</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Antiprotozoal Agents - therapeutic use</topic><topic>Antiprotozoal Agents - toxicity</topic><topic>Aqueous extracts</topic><topic>bark</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Cytotoxicity</topic><topic>Democratic Republic of the Congo</topic><topic>Dose-Response Relationship, Drug</topic><topic>DR Congo</topic><topic>Ethnopharmacology</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>inventories</topic><topic>Isolona</topic><topic>Leishmania infantum</topic><topic>Leishmania infantum - drug effects</topic><topic>Medicinal plants</topic><topic>Medicine, African Traditional</topic><topic>Parasitic Sensitivity Tests</topic><topic>parasitoses</topic><topic>Phytotherapy</topic><topic>Piptadeniastrum</topic><topic>plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Extracts - toxicity</topic><topic>Plants, Medicinal</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Protozoa</topic><topic>Quassia</topic><topic>roots</topic><topic>stems</topic><topic>Trypanocidal Agents - pharmacology</topic><topic>Trypanosoma brucei</topic><topic>Trypanosoma brucei brucei - drug effects</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Musuyu Muganza, D.</creatorcontrib><creatorcontrib>Fruth, B.I.</creatorcontrib><creatorcontrib>Nzunzu Lami, J.</creatorcontrib><creatorcontrib>Mesia, G.K.</creatorcontrib><creatorcontrib>Kambu, O.K.</creatorcontrib><creatorcontrib>Tona, G.L.</creatorcontrib><creatorcontrib>Cimanga Kanyanga, R.</creatorcontrib><creatorcontrib>Cos, P.</creatorcontrib><creatorcontrib>Maes, L.</creatorcontrib><creatorcontrib>Apers, S.</creatorcontrib><creatorcontrib>Pieters, L.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Musuyu Muganza, D.</au><au>Fruth, B.I.</au><au>Nzunzu Lami, J.</au><au>Mesia, G.K.</au><au>Kambu, O.K.</au><au>Tona, G.L.</au><au>Cimanga Kanyanga, R.</au><au>Cos, P.</au><au>Maes, L.</au><au>Apers, S.</au><au>Pieters, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2012-05-07</date><risdate>2012</risdate><volume>141</volume><issue>1</issue><spage>301</spage><epage>308</epage><pages>301-308</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for the treatment of various parasitic diseases and collected after an ethnopharmacological inventory conducted in the Bolongo area, Bandundu province in DR Congo, was evaluated.
Decoctions were prepared, lyophilized and evaluated for in vitro antiprotozoal activity against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum, and the chloroquine- and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Cytotoxicity against MRC-5 cells was included to assess selectivity of activity.
Most of the tested extracts exhibited pronounced (IC50≤5μg/ml) or good (5<IC50≤10μg/ml) antiprotozoal activity against one or more of the selected protozoa. A total of 19 plant extracts inhibited Trypanosoma b. brucei, especially the extract from Isolona hexaloba stem bark (IC50=1.95μg/ml, SI=16.5); 8 plant extracts were active against Trypanosoma cruzi, the extracts from Enanatia chlorantha stem bark and Quassia africana root bark being the most active with IC50 values of 1.87 and 1.88μg/ml, respectively (SI=3.0 and 3.3, respectively); 8 plant extracts showed activity against Leishmania infantum, with extracts from Napoleona vogelii stem bark and Quassia africana root bark as the most active with IC50 values of 5.66 and 5.04μg/ml (SI=11.3 and 1.2). Finally, 9 plant extracts inhibited Plasmodium falciparum K1 with the extracts from Quassia africana (root bark and stem bark) being the most active ones with IC50 values of 0.46 and 1.27μg/ml (SI=13.7 and 13.6). Extracts from Enantia chlorantha stem bark, Piptadeniastrum africanum stem bark and Quassia africana root bark were cytotoxic for MRC-5 cells (CC50<10μg/ml).
These results can partly support and justify the traditional use of some of these plant species for the treatment of parasitic diseases.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22394563</pmid><doi>10.1016/j.jep.2012.02.035</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2012-05, Vol.141 (1), p.301-308 |
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| subjects | Annickia Antimalarials - pharmacology Antiprotozoal activity Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Antiprotozoal Agents - toxicity Aqueous extracts bark Cell Line Cell Survival - drug effects Cytotoxicity Democratic Republic of the Congo Dose-Response Relationship, Drug DR Congo Ethnopharmacology Humans Inhibitory Concentration 50 inventories Isolona Leishmania infantum Leishmania infantum - drug effects Medicinal plants Medicine, African Traditional Parasitic Sensitivity Tests parasitoses Phytotherapy Piptadeniastrum plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Extracts - toxicity Plants, Medicinal Plasmodium falciparum Plasmodium falciparum - drug effects Protozoa Quassia roots stems Trypanocidal Agents - pharmacology Trypanosoma brucei Trypanosoma brucei brucei - drug effects Trypanosoma cruzi Trypanosoma cruzi - drug effects |
| title | In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo |
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