Comparative in vitro toll-like receptor ligand induced cytokine profiles of Toda and Murrah buffaloes—Identification of tumour necrosis factor alpha promoter polymorphism

The objective of this study was to assess cytokine production upon activation of pattern recognition receptors responsible for sensing bacterial and viral pathogen associated molecular patterns in two genetically diverse buffalo breeds, Toda and Murrah. A very limited molecular-epidemiological analy...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2012-12, Vol.150 (3-4), p.189-197
Hauptverfasser:	Vignesh, A.R., Dhinakar Raj, G., Dhanasekaran, S., Tirumurugaan, K.G., Raja, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Aminoquinolines - pharmacology Anaplasma Anaplasma - isolation & purification Anaplasmosis - blood Anaplasmosis - diagnosis Anaplasmosis - immunology Animals Bacteria - metabolism breeds buffaloes Buffaloes - genetics Buffaloes - metabolism Cytokines Cytokines - genetics Cytokines - metabolism disease resistance flagellin Gene Expression Regulation - immunology genetic polymorphism interferon-gamma Leukocytes, Mononuclear - metabolism Ligands lipopolysaccharides Lipopolysaccharides - pharmacology messenger RNA mononuclear leukocytes Murrah pathogens Peptidoglycan - pharmacology peptidoglycans Polymorphism, Genetic promoter regions Promoter Regions, Genetic - genetics Quantitative real time PCR receptors RNA, Messenger - genetics RNA, Messenger - metabolism Theileria Theileria - isolation & purification Theileriasis - blood Theileriasis - diagnosis Theileriasis - immunology TLR ligands Toda Toll like receptor Toll-Like Receptors - agonists transcription (genetics) tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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