Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Excess free fatty acids (FFAs) are known to induce insulin resistance, and a role for TLR4 has been implicated in this process. But FFAs are believed to be incapable of binding TLR4 directly. In a new study, Samir Bhattacharya and colleagues show that fetuin-A acts as an intermediary in this process...

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Veröffentlicht in:	Nature medicine 2012-08, Vol.18 (8), p.1279-1285
Hauptverfasser:	Pal, Durba, Dasgupta, Suman, Kundu, Rakesh, Maitra, Sudipta, Das, Gobardhan, Mukhopadhyay, Satinath, Ray, Sukanta, Majumdar, Subeer S, Bhattacharya, Samir
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells 631/80/86 692/420/256 692/699/2743/137 Adipocytes - chemistry Adipocytes - drug effects Adipocytes - physiology Adipose tissue Alpha fetoproteins alpha-2-HS-Glycoprotein - antagonists & inhibitors alpha-2-HS-Glycoprotein - chemistry alpha-2-HS-Glycoprotein - physiology alpha-2-HS-Glycoprotein - toxicity Animals Base Sequence Binding Sites Biomedical and Life Sciences Biomedicine Blood Glucose - analysis Cancer Research Care and treatment Chronic Disease Cytokines Cytokines - biosynthesis Cytokines - genetics Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Diagnosis Dietary Fats - toxicity Fatty acids Fatty Acids, Nonesterified - pharmacology Galactosides - metabolism Gene expression Gene Expression Regulation - drug effects Health aspects Humans Immune system Infectious Diseases Inflammation - chemically induced Inflammation - physiopathology Insulin resistance Insulin Resistance - physiology letter Ligands Ligands (Biochemistry) Lipids Metabolic Diseases Mice Mice, Inbred BALB C Mice, Knockout Mice, Obese Molecular Medicine Molecular Sequence Data Neurosciences NF-kappa B - metabolism Obesity - blood Obesity - physiopathology Receptors, Leptin - deficiency Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Toll-Like Receptor 4 - analysis Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - chemistry Toll-Like Receptor 4 - physiology
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