Association of changes in the gene expression profile of blood cells with the local tumor inflammatory response in a murine tumor model

► Subcutaneous Hepa1-6 tumors in C57Bl/6 mice are associated with the T-cell response. ► The tumors transiently developed, diminished, and ultimately vanished. ► Genes up-regulated in blood and tumors indicated T-cell-involved biological networks. ► Gene expression profiles in blood were associated...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-11, Vol.428 (1), p.36-43
Hauptverfasser:	Sakai, Yoshio, Tatsumi, Isamu, Higashimoto, Mami, Seki, Akihiro, Nasti, Alessandro, Yoshida, Keiko, Kawaguchi, Kazunori, Wada, Takashi, Honda, Masao, Komura, Takuya, Kaneko, Shuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Blood cells Blood Cells - metabolism Carcinoma, Hepatocellular - blood CD4 antigen Cell Line, Tumor Disease Models, Animal DNA microarrays Female Gene expression Gene expression profile Gene Expression Profiling Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Immune response Immune response (cell-mediated) Inflammation Inflammation - blood Liver Neoplasms - blood Local tumor inflammation Lymphocytes T Mice Mice, Inbred C57BL Peripheral blood Peripheral blood cell Tumors Up-Regulation
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