HPLC determination and pharmacokinetics of the new original domestic drug dibufelon
A simple, specific, sensitive, and precise high-performance liquid chromatography (HPLC) assay with UV detection has been developed for quantitative determination of fenozan acid in human blood plasma. Using this method, the pharmacokinetics of the new domestic preparation dibufelon (OOO Consortium-...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical chemistry journal 2009-11, Vol.43 (11), p.641-643 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 643 |
|---|---|
| container_issue | 11 |
| container_start_page | 641 |
| container_title | Pharmaceutical chemistry journal |
| container_volume | 43 |
| creator | Kondratenko, S. N Starodubtsev, A. K Belyakova, G. A |
| description | A simple, specific, sensitive, and precise high-performance liquid chromatography (HPLC) assay with UV detection has been developed for quantitative determination of fenozan acid in human blood plasma. Using this method, the pharmacokinetics of the new domestic preparation dibufelon (OOO Consortium-PIK, Russia) were investigated after a single peroral administration of an 800-mg dose in 12 healthy volunteers. It is established that the drug is rapidly absorbed from the GI tract into the systemic blood flow [C max ,178 ± 29 ng/mL; T max, 3.9 ± 0.5 h; AUC ₀₋∞, 1434 ± 269 (ng ∙ h)/mL; C max/AUC ₀₋∞, 0.135 ± 0.011 L/h], rather well retained in humans (MRT, 8.6 ± 0.8 h; T ₁/₂, 5.3 ± 0.8 h), and, despite a rapid total clearance (Cl t ,824 ± 167 L/h), penetrates well into organs and tissues (V Z , 5590 ± 1204 L). |
| doi_str_mv | 10.1007/s11094-010-0370-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1221136093</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1221136093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-632f69d1baa1cfc3feada13f17cedbb4414914843dcd864718a512ddd322cdc13</originalsourceid><addsrcrecordid>eNp9kMtKAzEUQIMoWB8f4Mos3Yzem6TzWErxBQWFKrgLaR5t6sykJjOIf29kXLvK4p5zuTmEXCBcI0B1kxChEQUgFMArKMQBmeG84kUDHA_JDKDBAufwfkxOUtpBBoGzGVk9viwX1NjBxs73avChp6o3dL9VsVM6fPjeDl4nGhwdtpb29ouG6DeZbakJnU15Sk0cN9T49ehsG_ozcuRUm-z533tK3u7vXhePxfL54Wlxuyw0F_OhKDlzZWNwrRRqp7mzyijkDittzXotBIoGRS240aYuRYW1miMzxnDGtNHIT8nVtHcfw-eYL5GdT9q2reptGJNExhB5CQ3PKE6ojiGlaJ3cR9-p-C0R5G9AOQWUuYv8DShFdtjkpMz2GxvlLowx_zv9K11OklNBqk30Sb6tGCAHrKEuG8F_AKOtfUU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1221136093</pqid></control><display><type>article</type><title>HPLC determination and pharmacokinetics of the new original domestic drug dibufelon</title><source>Springer Nature - Complete Springer Journals</source><creator>Kondratenko, S. N ; Starodubtsev, A. K ; Belyakova, G. A</creator><creatorcontrib>Kondratenko, S. N ; Starodubtsev, A. K ; Belyakova, G. A</creatorcontrib><description>A simple, specific, sensitive, and precise high-performance liquid chromatography (HPLC) assay with UV detection has been developed for quantitative determination of fenozan acid in human blood plasma. Using this method, the pharmacokinetics of the new domestic preparation dibufelon (OOO Consortium-PIK, Russia) were investigated after a single peroral administration of an 800-mg dose in 12 healthy volunteers. It is established that the drug is rapidly absorbed from the GI tract into the systemic blood flow [C max ,178 ± 29 ng/mL; T max, 3.9 ± 0.5 h; AUC ₀₋∞, 1434 ± 269 (ng ∙ h)/mL; C max/AUC ₀₋∞, 0.135 ± 0.011 L/h], rather well retained in humans (MRT, 8.6 ± 0.8 h; T ₁/₂, 5.3 ± 0.8 h), and, despite a rapid total clearance (Cl t ,824 ± 167 L/h), penetrates well into organs and tissues (V Z , 5590 ± 1204 L).</description><identifier>ISSN: 0091-150X</identifier><identifier>EISSN: 1573-9031</identifier><identifier>DOI: 10.1007/s11094-010-0370-4</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Drugs ; fenozan acid ; Gastrointestinal tract ; High-performance liquid chromatography ; HPLC ; Medicine ; Organic Chemistry ; Pharmacokinetics ; Pharmacology/Toxicology ; Pharmacy ; plasma</subject><ispartof>Pharmaceutical chemistry journal, 2009-11, Vol.43 (11), p.641-643</ispartof><rights>Springer Science+Business Media, Inc. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-632f69d1baa1cfc3feada13f17cedbb4414914843dcd864718a512ddd322cdc13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11094-010-0370-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11094-010-0370-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids></links><search><creatorcontrib>Kondratenko, S. N</creatorcontrib><creatorcontrib>Starodubtsev, A. K</creatorcontrib><creatorcontrib>Belyakova, G. A</creatorcontrib><title>HPLC determination and pharmacokinetics of the new original domestic drug dibufelon</title><title>Pharmaceutical chemistry journal</title><addtitle>Pharm Chem J</addtitle><description>A simple, specific, sensitive, and precise high-performance liquid chromatography (HPLC) assay with UV detection has been developed for quantitative determination of fenozan acid in human blood plasma. Using this method, the pharmacokinetics of the new domestic preparation dibufelon (OOO Consortium-PIK, Russia) were investigated after a single peroral administration of an 800-mg dose in 12 healthy volunteers. It is established that the drug is rapidly absorbed from the GI tract into the systemic blood flow [C max ,178 ± 29 ng/mL; T max, 3.9 ± 0.5 h; AUC ₀₋∞, 1434 ± 269 (ng ∙ h)/mL; C max/AUC ₀₋∞, 0.135 ± 0.011 L/h], rather well retained in humans (MRT, 8.6 ± 0.8 h; T ₁/₂, 5.3 ± 0.8 h), and, despite a rapid total clearance (Cl t ,824 ± 167 L/h), penetrates well into organs and tissues (V Z , 5590 ± 1204 L).</description><subject>Drugs</subject><subject>fenozan acid</subject><subject>Gastrointestinal tract</subject><subject>High-performance liquid chromatography</subject><subject>HPLC</subject><subject>Medicine</subject><subject>Organic Chemistry</subject><subject>Pharmacokinetics</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>plasma</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUQIMoWB8f4Mos3Yzem6TzWErxBQWFKrgLaR5t6sykJjOIf29kXLvK4p5zuTmEXCBcI0B1kxChEQUgFMArKMQBmeG84kUDHA_JDKDBAufwfkxOUtpBBoGzGVk9viwX1NjBxs73avChp6o3dL9VsVM6fPjeDl4nGhwdtpb29ouG6DeZbakJnU15Sk0cN9T49ehsG_ozcuRUm-z533tK3u7vXhePxfL54Wlxuyw0F_OhKDlzZWNwrRRqp7mzyijkDittzXotBIoGRS240aYuRYW1miMzxnDGtNHIT8nVtHcfw-eYL5GdT9q2reptGJNExhB5CQ3PKE6ojiGlaJ3cR9-p-C0R5G9AOQWUuYv8DShFdtjkpMz2GxvlLowx_zv9K11OklNBqk30Sb6tGCAHrKEuG8F_AKOtfUU</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Kondratenko, S. N</creator><creator>Starodubtsev, A. K</creator><creator>Belyakova, G. A</creator><general>Boston : Springer US</general><general>Springer US</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20091101</creationdate><title>HPLC determination and pharmacokinetics of the new original domestic drug dibufelon</title><author>Kondratenko, S. N ; Starodubtsev, A. K ; Belyakova, G. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-632f69d1baa1cfc3feada13f17cedbb4414914843dcd864718a512ddd322cdc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Drugs</topic><topic>fenozan acid</topic><topic>Gastrointestinal tract</topic><topic>High-performance liquid chromatography</topic><topic>HPLC</topic><topic>Medicine</topic><topic>Organic Chemistry</topic><topic>Pharmacokinetics</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>plasma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondratenko, S. N</creatorcontrib><creatorcontrib>Starodubtsev, A. K</creatorcontrib><creatorcontrib>Belyakova, G. A</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondratenko, S. N</au><au>Starodubtsev, A. K</au><au>Belyakova, G. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HPLC determination and pharmacokinetics of the new original domestic drug dibufelon</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2009-11-01</date><risdate>2009</risdate><volume>43</volume><issue>11</issue><spage>641</spage><epage>643</epage><pages>641-643</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>A simple, specific, sensitive, and precise high-performance liquid chromatography (HPLC) assay with UV detection has been developed for quantitative determination of fenozan acid in human blood plasma. Using this method, the pharmacokinetics of the new domestic preparation dibufelon (OOO Consortium-PIK, Russia) were investigated after a single peroral administration of an 800-mg dose in 12 healthy volunteers. It is established that the drug is rapidly absorbed from the GI tract into the systemic blood flow [C max ,178 ± 29 ng/mL; T max, 3.9 ± 0.5 h; AUC ₀₋∞, 1434 ± 269 (ng ∙ h)/mL; C max/AUC ₀₋∞, 0.135 ± 0.011 L/h], rather well retained in humans (MRT, 8.6 ± 0.8 h; T ₁/₂, 5.3 ± 0.8 h), and, despite a rapid total clearance (Cl t ,824 ± 167 L/h), penetrates well into organs and tissues (V Z , 5590 ± 1204 L).</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><doi>10.1007/s11094-010-0370-4</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-150X |
| ispartof | Pharmaceutical chemistry journal, 2009-11, Vol.43 (11), p.641-643 |
| issn | 0091-150X 1573-9031 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1221136093 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Drugs fenozan acid Gastrointestinal tract High-performance liquid chromatography HPLC Medicine Organic Chemistry Pharmacokinetics Pharmacology/Toxicology Pharmacy plasma |
| title | HPLC determination and pharmacokinetics of the new original domestic drug dibufelon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T20%3A19%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HPLC%20determination%20and%20pharmacokinetics%20of%20the%20new%20original%20domestic%20drug%20dibufelon&rft.jtitle=Pharmaceutical%20chemistry%20journal&rft.au=Kondratenko,%20S.%20N&rft.date=2009-11-01&rft.volume=43&rft.issue=11&rft.spage=641&rft.epage=643&rft.pages=641-643&rft.issn=0091-150X&rft.eissn=1573-9031&rft_id=info:doi/10.1007/s11094-010-0370-4&rft_dat=%3Cproquest_cross%3E1221136093%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1221136093&rft_id=info:pmid/&rfr_iscdi=true |