Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lytraceae) in experimental animals

Lafoensia pacari St.-Hil. is a tree native to the Brazilian Cerrado. Its bark macerate is popularly used in Brazilian folk medicine for the treatment of peptic ulcer, wound healing and inflammation. To evaluate the antiulcer activities of the methanol extract of Lafoensia pacari (MELP) and possible...

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Veröffentlicht in:	Journal of ethnopharmacology 2012-12, Vol.144 (3), p.497-505
Hauptverfasser:	Tamashiro Filho, Paulo, Sikiru Olaitan, Balogun, Tavares de Almeida, Danielle Ayr, Lima, Joaquim Corsino da Silva, Marson-Ascêncio, Poliana Guerino, Donizeti Ascêncio, Sérgio, Rios-Santos, Fabrício, Martins, Domingos Tabajara de Oliveira
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid acidity Animals anti-ulcer activity Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use bark Brazil cerrado Ellagic acid Ethanol gastric juice gastrointestinal motility Gastrointestinal Transit - drug effects Gastroprotective high performance liquid chromatography Indomethacin inflammation Interleukin-17 - blood laboratory animals Lafoensia pacari Lythraceae Male mechanism of action Medicine, Traditional methanol Methanol - chemistry Mice mucus necrosis phenols Phytotherapy Plant Bark Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar saponins secretion Solvents - chemistry steroids Stomach Ulcer - blood Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - physiopathology stomach ulcers Stress, Psychological tannins tissue repair traditional medicine trees tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - blood Ulcer healing
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