The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation

► Active Hexose Correlated Compound (AHCC) is used to boost the immune function. ► AHCC induced the production of GROα and MCP1 in IEC18 cells and of IL8 in HT29 cells. ► AHCC induced IL1β, IL6 and TNFα production in human monocytes (THP-1 cells). ► The stimulatory response was evoked by TLR4/MyD88,...

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Veröffentlicht in:	Food chemistry 2013-02, Vol.136 (3-4), p.1288-1295
Hauptverfasser:	Daddaoua, Abdelali, Martínez-Plata, Enrique, Ortega-González, Mercedes, Ocón, Borja, Aranda, Carlos J., Zarzuelo, Antonio, Suárez, María D., de Medina, Fermín Sánchez, Martínez-Augustin, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	AHCC Animals Biological and medical sciences Cell Line culture media cytokines dietary supplements Dietary Supplements - analysis Enterocyte enzyme-linked immunosorbent assay epithelial cells Epithelial Cells - drug effects Epithelial Cells - immunology Food industries Fundamental and applied biological sciences. Psychology Humans Immunologic Factors - immunology Immunologic Factors - pharmacology Intestines - cytology Intestines - drug effects Intestines - immunology Macrophage immunomodulatory macrophages Macrophages - drug effects Macrophages - immunology mechanism of action mitogen-activated protein kinase Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - immunology monocytes Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - immunology NF-kappa B - genetics NF-kappa B - immunology NFκB Polysaccharides - immunology Polysaccharides - pharmacology Rats secretion signal transduction TLR4 Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology
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