Activin A Stimulates AKR1C3 Expression and Growth in Human Prostate Cancer

Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. We investigated the effects of activin, a factor involved in the regulation of PC growth and...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-12, Vol.153 (12), p.5726-5734
Hauptverfasser:	Hofland, Johannes, van Weerden, Wytske M, Steenbergen, Jacobie, Dits, Natasja F. J, Jenster, Guido, de Jong, Frank H
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxysteroid Dehydrogenases - biosynthesis Activin Activins - metabolism Aldo-Keto Reductase Family 1 Member C3 Androgens Androgens - metabolism Androstenedione Animals Biological and medical sciences Castration Cell culture Cell Line, Tumor Cell Proliferation Disease Progression Enzymatic activity Enzyme activity Enzymes Follistatin Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Hydroxyprostaglandin Dehydrogenases - biosynthesis Hydroxysteroids Inhibin Male Male genital diseases Medical sciences Metastases Mice Neoplasm Metastasis Neoplasm Transplantation Nephrology. Urinary tract diseases Physiological effects Prostate cancer Prostatic Neoplasms - metabolism Signal Transduction Steroidogenesis Synthesis Testosterone Testosterone - metabolism Therapeutic targets Tumors Tumors of the urinary system Urinary tract. Prostate gland Vertebrates: endocrinology Xenografts Xenotransplantation
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