Atypical angiopoietin-like protein that regulates ANGPTL3

Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Inactivation of ANGPTL3 , a gene located in an intron of DOCK7 , results in very low levels of LDL-cholesterol (C), HDL-C and triglyceride (TAG). We identified another ANGPTL family member, ANGPTL8 , w...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-11, Vol.109 (48), p.19751-19756
Hauptverfasser:	Quagliarini, Fabiana, Wang, Yan, Kozlitina, Julia, Grishin, Nick V, Hyde, Rhonda, Boerwinkle, Eric, Valenzuela, David M, Murphy, Andrew J, Cohen, Jonathan C, Hobbs, Helen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses adipose tissue Amino Acid Sequence Angiopoietin-like Proteins Angiopoietins - chemistry Angiopoietins - metabolism Angiopoietins - physiology Animals Biological Sciences Cholesterol, HDL - blood Cholesterol, LDL - blood Family members fasting fatty acid metabolism Gene expression Gene expression regulation genes Guanine Nucleotide Exchange Factors - genetics hepatocytes humans hypertriglyceridemia Hypertriglyceridemia - physiopathology Introns Lipid metabolism Lipids Lipoproteins Liver Liver - metabolism low density lipoprotein cholesterol Messenger RNA Metabolism Mice Molecular Sequence Data Plasma Proteins refeeding Sequence Homology, Amino Acid triacylglycerols Triglycerides - blood
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