Treatment duration of extra-pulmonary tuberculosis: 6 months or more? TB-INFO database analysis
The recommended duration of pulmonary tuberculosis therapy is 6 months. For extrapulmonary tuberculosis, treatment duration depends on tuberculosis involvement and HIV status. The objective of this study was to describe the main characteristics of a cohort of extrapulmonary tuberculosis patients, to...
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| Veröffentlicht in: | La revue de medecine interne 2012-12, Vol.33 (12), p.665-671 |
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| creator | Bouchikh, S Stirnemann, J Prendki, V Porcher, R Kesthmand, H Morin, A-S Cruaud, P Rouaghe, S Farge, D Fain, O |
| description | The recommended duration of pulmonary tuberculosis therapy is 6 months. For extrapulmonary tuberculosis, treatment duration depends on tuberculosis involvement and HIV status. The objective of this study was to describe the main characteristics of a cohort of extrapulmonary tuberculosis patients, to compare patients with a 6-month treatment to those with more than a 6-month treatment, and to analyze the compliance of medical centres with recommended duration of treatment.
A retrospective cohort study of 210 patients with extrapulmonary tuberculosis was carried from January 1999 to December 2006 in two hospitals in the north-east of Paris. These patients were treated with quadruple therapy during two months, followed by dual therapy during 4 months (n=77) or more (n=66). The characteristics of each group were compared by uni- and multivariate analysis. The primary endpoint was the rate of relapse or treatment failure at 24-month follow-up after treatment completion.
No relapse was observed after 24 months of follow-up after the end of treatment in the two groups. In univariate analysis, patients with lymph node tuberculosis were more often treated for 6 months than at other sites of tuberculosis (respectively 61% versus 40.9%; P=0.02); the decision of treatment duration was related to medical practices (79.2% treated 6 months in one hospital versus 20.7% in the other, P |
| doi_str_mv | 10.1016/j.revmed.2012.05.008 |
| format | Article |
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A retrospective cohort study of 210 patients with extrapulmonary tuberculosis was carried from January 1999 to December 2006 in two hospitals in the north-east of Paris. These patients were treated with quadruple therapy during two months, followed by dual therapy during 4 months (n=77) or more (n=66). The characteristics of each group were compared by uni- and multivariate analysis. The primary endpoint was the rate of relapse or treatment failure at 24-month follow-up after treatment completion.
No relapse was observed after 24 months of follow-up after the end of treatment in the two groups. In univariate analysis, patients with lymph node tuberculosis were more often treated for 6 months than at other sites of tuberculosis (respectively 61% versus 40.9%; P=0.02); the decision of treatment duration was related to medical practices (79.2% treated 6 months in one hospital versus 20.7% in the other, P<0.001); patients living in private residence were more often treated during 6 months than patients living in residence (24.2% versus 10.3%, P=0.042). In multivariate analysis, only hospital (P=0.046), sex (P=0.007) and private residence were significantly different in each group.
A period of 6 months seems to be sufficient to treat extrapulmonary tuberculosis (except for neuromeningeal localization).</description><identifier>EISSN: 1768-3122</identifier><identifier>DOI: 10.1016/j.revmed.2012.05.008</identifier><identifier>PMID: 22703726</identifier><language>fre</language><publisher>France</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; AIDS-Related Opportunistic Infections - drug therapy ; Algorithms ; Antitubercular Agents - therapeutic use ; Cohort Studies ; Continuity of Patient Care - statistics & numerical data ; Data Interpretation, Statistical ; Databases, Factual - statistics & numerical data ; Drug Administration Schedule ; Female ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Humans ; Male ; Middle Aged ; Paris - epidemiology ; Patient Compliance - statistics & numerical data ; Retrospective Studies ; Time Factors ; Tuberculosis - complications ; Tuberculosis - drug therapy ; Tuberculosis - epidemiology ; Young Adult</subject><ispartof>La revue de medecine interne, 2012-12, Vol.33 (12), p.665-671</ispartof><rights>Copyright © 2012. Published by Elsevier SAS.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22703726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouchikh, S</creatorcontrib><creatorcontrib>Stirnemann, J</creatorcontrib><creatorcontrib>Prendki, V</creatorcontrib><creatorcontrib>Porcher, R</creatorcontrib><creatorcontrib>Kesthmand, H</creatorcontrib><creatorcontrib>Morin, A-S</creatorcontrib><creatorcontrib>Cruaud, P</creatorcontrib><creatorcontrib>Rouaghe, S</creatorcontrib><creatorcontrib>Farge, D</creatorcontrib><creatorcontrib>Fain, O</creatorcontrib><title>Treatment duration of extra-pulmonary tuberculosis: 6 months or more? TB-INFO database analysis</title><title>La revue de medecine interne</title><addtitle>Rev Med Interne</addtitle><description>The recommended duration of pulmonary tuberculosis therapy is 6 months. For extrapulmonary tuberculosis, treatment duration depends on tuberculosis involvement and HIV status. The objective of this study was to describe the main characteristics of a cohort of extrapulmonary tuberculosis patients, to compare patients with a 6-month treatment to those with more than a 6-month treatment, and to analyze the compliance of medical centres with recommended duration of treatment.
A retrospective cohort study of 210 patients with extrapulmonary tuberculosis was carried from January 1999 to December 2006 in two hospitals in the north-east of Paris. These patients were treated with quadruple therapy during two months, followed by dual therapy during 4 months (n=77) or more (n=66). The characteristics of each group were compared by uni- and multivariate analysis. The primary endpoint was the rate of relapse or treatment failure at 24-month follow-up after treatment completion.
No relapse was observed after 24 months of follow-up after the end of treatment in the two groups. In univariate analysis, patients with lymph node tuberculosis were more often treated for 6 months than at other sites of tuberculosis (respectively 61% versus 40.9%; P=0.02); the decision of treatment duration was related to medical practices (79.2% treated 6 months in one hospital versus 20.7% in the other, P<0.001); patients living in private residence were more often treated during 6 months than patients living in residence (24.2% versus 10.3%, P=0.042). In multivariate analysis, only hospital (P=0.046), sex (P=0.007) and private residence were significantly different in each group.
A period of 6 months seems to be sufficient to treat extrapulmonary tuberculosis (except for neuromeningeal localization).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>Algorithms</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Cohort Studies</subject><subject>Continuity of Patient Care - statistics & numerical data</subject><subject>Data Interpretation, Statistical</subject><subject>Databases, Factual - statistics & numerical data</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Paris - epidemiology</subject><subject>Patient Compliance - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Tuberculosis - complications</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis - epidemiology</subject><subject>Young Adult</subject><issn>1768-3122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLw0AUhQdBbK3-A5FZukm8M8nk4Ua0WC0Uu4nrcJPcYEpezkPsv3fAujqXw8eF8zF2IyAUIJL7Q6jpe6AmlCBkCCoEyM7YUqRJFkRCygW7NOYAAJ7OL9hCyhSiVCZLVhaa0A40Wt44jbabRj61nH6sxmB2_TCNqI_cuop07frJdOaBJ9zX9tPwSftL0yMvnoPt-2bPG7RYoSGOI_ZHD1-x8xZ7Q9enXLGPzUuxfgt2-9ft-mkXzCIWNoirmKK8ElS3jUoTIJVJUmkq2jiLlRAkpcol1ugXkUKM4iiDBgVCnaOsKFqxu7-_s56-HBlbDp2pqe9xpMmZ0ksAleSpAI_enlBXeWflrLvBbyz_pUS_cwxj7g</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Bouchikh, S</creator><creator>Stirnemann, J</creator><creator>Prendki, V</creator><creator>Porcher, R</creator><creator>Kesthmand, H</creator><creator>Morin, A-S</creator><creator>Cruaud, P</creator><creator>Rouaghe, S</creator><creator>Farge, D</creator><creator>Fain, O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Treatment duration of extra-pulmonary tuberculosis: 6 months or more? TB-INFO database analysis</title><author>Bouchikh, S ; Stirnemann, J ; Prendki, V ; Porcher, R ; Kesthmand, H ; Morin, A-S ; Cruaud, P ; Rouaghe, S ; Farge, D ; Fain, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-4b4e39b1ecfd5760e582e5771f484511e22592aca768e5aa34380da1a0c9a2be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>AIDS-Related Opportunistic Infections - drug therapy</topic><topic>Algorithms</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Cohort Studies</topic><topic>Continuity of Patient Care - statistics & numerical data</topic><topic>Data Interpretation, Statistical</topic><topic>Databases, Factual - statistics & numerical data</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Paris - epidemiology</topic><topic>Patient Compliance - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Tuberculosis - complications</topic><topic>Tuberculosis - drug therapy</topic><topic>Tuberculosis - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouchikh, S</creatorcontrib><creatorcontrib>Stirnemann, J</creatorcontrib><creatorcontrib>Prendki, V</creatorcontrib><creatorcontrib>Porcher, R</creatorcontrib><creatorcontrib>Kesthmand, H</creatorcontrib><creatorcontrib>Morin, A-S</creatorcontrib><creatorcontrib>Cruaud, P</creatorcontrib><creatorcontrib>Rouaghe, S</creatorcontrib><creatorcontrib>Farge, D</creatorcontrib><creatorcontrib>Fain, O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>La revue de medecine interne</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouchikh, S</au><au>Stirnemann, J</au><au>Prendki, V</au><au>Porcher, R</au><au>Kesthmand, H</au><au>Morin, A-S</au><au>Cruaud, P</au><au>Rouaghe, S</au><au>Farge, D</au><au>Fain, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment duration of extra-pulmonary tuberculosis: 6 months or more? TB-INFO database analysis</atitle><jtitle>La revue de medecine interne</jtitle><addtitle>Rev Med Interne</addtitle><date>2012-12</date><risdate>2012</risdate><volume>33</volume><issue>12</issue><spage>665</spage><epage>671</epage><pages>665-671</pages><eissn>1768-3122</eissn><abstract>The recommended duration of pulmonary tuberculosis therapy is 6 months. For extrapulmonary tuberculosis, treatment duration depends on tuberculosis involvement and HIV status. The objective of this study was to describe the main characteristics of a cohort of extrapulmonary tuberculosis patients, to compare patients with a 6-month treatment to those with more than a 6-month treatment, and to analyze the compliance of medical centres with recommended duration of treatment.
A retrospective cohort study of 210 patients with extrapulmonary tuberculosis was carried from January 1999 to December 2006 in two hospitals in the north-east of Paris. These patients were treated with quadruple therapy during two months, followed by dual therapy during 4 months (n=77) or more (n=66). The characteristics of each group were compared by uni- and multivariate analysis. The primary endpoint was the rate of relapse or treatment failure at 24-month follow-up after treatment completion.
No relapse was observed after 24 months of follow-up after the end of treatment in the two groups. In univariate analysis, patients with lymph node tuberculosis were more often treated for 6 months than at other sites of tuberculosis (respectively 61% versus 40.9%; P=0.02); the decision of treatment duration was related to medical practices (79.2% treated 6 months in one hospital versus 20.7% in the other, P<0.001); patients living in private residence were more often treated during 6 months than patients living in residence (24.2% versus 10.3%, P=0.042). In multivariate analysis, only hospital (P=0.046), sex (P=0.007) and private residence were significantly different in each group.
A period of 6 months seems to be sufficient to treat extrapulmonary tuberculosis (except for neuromeningeal localization).</abstract><cop>France</cop><pmid>22703726</pmid><doi>10.1016/j.revmed.2012.05.008</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over AIDS-Related Opportunistic Infections - drug therapy Algorithms Antitubercular Agents - therapeutic use Cohort Studies Continuity of Patient Care - statistics & numerical data Data Interpretation, Statistical Databases, Factual - statistics & numerical data Drug Administration Schedule Female HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology Humans Male Middle Aged Paris - epidemiology Patient Compliance - statistics & numerical data Retrospective Studies Time Factors Tuberculosis - complications Tuberculosis - drug therapy Tuberculosis - epidemiology Young Adult |
| title | Treatment duration of extra-pulmonary tuberculosis: 6 months or more? TB-INFO database analysis |
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