Variants in the LEPR Gene Are Nominally Associated With Higher BMI and Lower 24‐h Energy Expenditure in Pima Indians

Genome‐wide association studies (GWASs) have been used to search for susceptibility genes for type 2 diabetes and obesity in the Pima Indians, a population with a high prevalence of both diseases. In these studies, a variant (rs2025804) in the LEPR gene was nominally associated with BMI in 1,082 sub...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2012-12, Vol.20 (12), p.2426-2430
Hauptverfasser:	Traurig, Michael T., Perez, Jessica M., Ma, Lijun, Bian, Li, Kobes, Sayuko, Hanson, Robert L., Knowler, William C., Krakoff, Jonathan A., Bogardus, Clifton, Baier, Leslie J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Body Mass Index Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Energy Energy Metabolism - genetics Female Genetic Predisposition to Disease Genetics Genome-Wide Association Study Genotype Humans Indians, North American - genetics Male Native North Americans Obesity - epidemiology Obesity - genetics Obesity - metabolism Phenotype Polymorphism, Single Nucleotide Postprandial Period Receptors, Leptin - genetics Receptors, Leptin - metabolism Thermogenesis
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