Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study
Background The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD). Methods Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC,...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2013, Vol.28 (1), p.115-120 |
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| creator | Shatat, Ibrahim F. Jakson, Sherron M. Blue, Amanda E. Johnson, Mary A. Orak, John K. Kalpatthi, Ram |
| description | Background
The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD).
Methods
Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected.
Results
Median age was 13 years (range 11–16), body mass index (BMI) 19.1 kg/m
2
(range 18.2–21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38,
P
= 0.02).
Conclusion
Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP. |
| doi_str_mv | 10.1007/s00467-012-2275-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1220368098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A335070826</galeid><sourcerecordid>A335070826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-3ecbd18f54f91d678c3ae9bb7091b34da7cad07af836eb2adfdd48b32570eb2b3</originalsourceid><addsrcrecordid>eNp1kl1rFDEYhQdR7Fr9Ad5IQBBvpr5J5iPjXVn8gla9UOhdyCTv7KSdTbZJpmX_vVm2aisruQhJnvNyODlF8ZLCCQVo30WAqmlLoKxkrK3L7lGxoBVnJe3ExeNiAR2nJVT04qh4FuMlAIhaNE-LI8aEaJigi-LmXMUrNGTcbjAkdNF6R2wkm4A3akKXiHVEj3YyAR25tWkk0eqrCYnGaSLGRlQR3xNFzq25xZjIdzRWpWA1-YqbMfjJr7Zk6V30Idl5TWKazfZ58WRQU8QXd_tx8fPjhx_Lz-XZt09flqdnpa5BpJKj7g0VQ10NHTVNKzRX2PV9Cx3teWVUq5WBVg2CN9gzZQZjKtFzVreQzz0_Lt7u526Cv56zPbm2cedcOfRzlJQx4I2ATmT09T_opZ-Dy-4kpV0LTdN01V9qldOR1g0-BaV3Q-Up5zW0IFiTqfIAtUKHQU3e4WDz9QP-5ACfl8G11QcFb-4JRlRTGqOf5pS_Lz4E6R7UwccYcJCbYNcqbCUFuSuR3JdI5hLJXYlklzWv7pKY-zWaP4rfrckA2wMxP7kVhntR_XfqL1q80Vk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1197066694</pqid></control><display><type>article</type><title>Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Shatat, Ibrahim F. ; Jakson, Sherron M. ; Blue, Amanda E. ; Johnson, Mary A. ; Orak, John K. ; Kalpatthi, Ram</creator><creatorcontrib>Shatat, Ibrahim F. ; Jakson, Sherron M. ; Blue, Amanda E. ; Johnson, Mary A. ; Orak, John K. ; Kalpatthi, Ram</creatorcontrib><description>Background
The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD).
Methods
Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected.
Results
Median age was 13 years (range 11–16), body mass index (BMI) 19.1 kg/m
2
(range 18.2–21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38,
P
= 0.02).
Conclusion
Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-012-2275-9</identifier><identifier>PMID: 22886281</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Anemia ; Anemia, Sickle Cell - complications ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Body mass index ; Care and treatment ; Child ; Children ; Consortia ; Diagnosis ; Female ; Health aspects ; Hematology ; Humans ; Hypertension ; Male ; Masked Hypertension - complications ; Masked Hypertension - epidemiology ; Medicine ; Medicine & Public Health ; Mortality ; Nephrology ; Original Article ; Pediatrics ; Prevalence ; Risk factors ; Sickle cell anemia ; Sickle cell disease ; Stroke (Disease) ; United States ; Urology</subject><ispartof>Pediatric nephrology (Berlin, West), 2013, Vol.28 (1), p.115-120</ispartof><rights>IPNA 2012</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-3ecbd18f54f91d678c3ae9bb7091b34da7cad07af836eb2adfdd48b32570eb2b3</citedby><cites>FETCH-LOGICAL-c508t-3ecbd18f54f91d678c3ae9bb7091b34da7cad07af836eb2adfdd48b32570eb2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-012-2275-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-012-2275-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22886281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shatat, Ibrahim F.</creatorcontrib><creatorcontrib>Jakson, Sherron M.</creatorcontrib><creatorcontrib>Blue, Amanda E.</creatorcontrib><creatorcontrib>Johnson, Mary A.</creatorcontrib><creatorcontrib>Orak, John K.</creatorcontrib><creatorcontrib>Kalpatthi, Ram</creatorcontrib><title>Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD).
Methods
Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected.
Results
Median age was 13 years (range 11–16), body mass index (BMI) 19.1 kg/m
2
(range 18.2–21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38,
P
= 0.02).
Conclusion
Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP.</description><subject>Adolescent</subject><subject>Anemia</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Blood Pressure</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Children</subject><subject>Consortia</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Masked Hypertension - complications</subject><subject>Masked Hypertension - epidemiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Prevalence</subject><subject>Risk factors</subject><subject>Sickle cell anemia</subject><subject>Sickle cell disease</subject><subject>Stroke (Disease)</subject><subject>United States</subject><subject>Urology</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kl1rFDEYhQdR7Fr9Ad5IQBBvpr5J5iPjXVn8gla9UOhdyCTv7KSdTbZJpmX_vVm2aisruQhJnvNyODlF8ZLCCQVo30WAqmlLoKxkrK3L7lGxoBVnJe3ExeNiAR2nJVT04qh4FuMlAIhaNE-LI8aEaJigi-LmXMUrNGTcbjAkdNF6R2wkm4A3akKXiHVEj3YyAR25tWkk0eqrCYnGaSLGRlQR3xNFzq25xZjIdzRWpWA1-YqbMfjJr7Zk6V30Idl5TWKazfZ58WRQU8QXd_tx8fPjhx_Lz-XZt09flqdnpa5BpJKj7g0VQ10NHTVNKzRX2PV9Cx3teWVUq5WBVg2CN9gzZQZjKtFzVreQzz0_Lt7u526Cv56zPbm2cedcOfRzlJQx4I2ATmT09T_opZ-Dy-4kpV0LTdN01V9qldOR1g0-BaV3Q-Up5zW0IFiTqfIAtUKHQU3e4WDz9QP-5ACfl8G11QcFb-4JRlRTGqOf5pS_Lz4E6R7UwccYcJCbYNcqbCUFuSuR3JdI5hLJXYlklzWv7pKY-zWaP4rfrckA2wMxP7kVhntR_XfqL1q80Vk</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Shatat, Ibrahim F.</creator><creator>Jakson, Sherron M.</creator><creator>Blue, Amanda E.</creator><creator>Johnson, Mary A.</creator><creator>Orak, John K.</creator><creator>Kalpatthi, Ram</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study</title><author>Shatat, Ibrahim F. ; Jakson, Sherron M. ; Blue, Amanda E. ; Johnson, Mary A. ; Orak, John K. ; Kalpatthi, Ram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-3ecbd18f54f91d678c3ae9bb7091b34da7cad07af836eb2adfdd48b32570eb2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Anemia</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Blood Pressure</topic><topic>Blood Pressure Monitoring, Ambulatory</topic><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Children</topic><topic>Consortia</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Masked Hypertension - complications</topic><topic>Masked Hypertension - epidemiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Prevalence</topic><topic>Risk factors</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><topic>Stroke (Disease)</topic><topic>United States</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shatat, Ibrahim F.</creatorcontrib><creatorcontrib>Jakson, Sherron M.</creatorcontrib><creatorcontrib>Blue, Amanda E.</creatorcontrib><creatorcontrib>Johnson, Mary A.</creatorcontrib><creatorcontrib>Orak, John K.</creatorcontrib><creatorcontrib>Kalpatthi, Ram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shatat, Ibrahim F.</au><au>Jakson, Sherron M.</au><au>Blue, Amanda E.</au><au>Johnson, Mary A.</au><au>Orak, John K.</au><au>Kalpatthi, Ram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2013</date><risdate>2013</risdate><volume>28</volume><issue>1</issue><spage>115</spage><epage>120</epage><pages>115-120</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD).
Methods
Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected.
Results
Median age was 13 years (range 11–16), body mass index (BMI) 19.1 kg/m
2
(range 18.2–21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38,
P
= 0.02).
Conclusion
Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22886281</pmid><doi>10.1007/s00467-012-2275-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 2013, Vol.28 (1), p.115-120 |
| issn | 0931-041X 1432-198X |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Anemia Anemia, Sickle Cell - complications Blood Pressure Blood Pressure Monitoring, Ambulatory Body mass index Care and treatment Child Children Consortia Diagnosis Female Health aspects Hematology Humans Hypertension Male Masked Hypertension - complications Masked Hypertension - epidemiology Medicine Medicine & Public Health Mortality Nephrology Original Article Pediatrics Prevalence Risk factors Sickle cell anemia Sickle cell disease Stroke (Disease) United States Urology |
| title | Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study |
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