Inter-Individual Differences in Baseline Coagulation Activities and Their Implications for International Normalized Ratio Control During Warfarin Initiation Therapy

Background and Objective Genetic polymorphisms of cytochrome P450 (CYP) 2C9 ( CYP2C9 ) and vitamin K epoxide reductase complex subunit 1 ( VKORC1 ) and patient demographic characteristics are responsible for inter-individual differences in warfarin maintenance dosage requirements. At present, howeve...

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Veröffentlicht in:	Clinical pharmacokinetics 2012-12, Vol.51 (12), p.799-808
Hauptverfasser:	Ichimura, Yosuke, Takahashi, Harumi, Lee, Michael T. M., Shiomi, Mari, Mihara, Kiyoshi, Morita, Takashi, Chen, Yuan-Tsong, Echizen, Hirotoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticoagulants - pharmacology Anticoagulants - therapeutic use Asian Continental Ancestry Group - genetics Biological and medical sciences Blood Coagulation - drug effects Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Family 4 Female General pharmacology Humans Internal Medicine International Normalized Ratio Male Medical sciences Medicine Medicine & Public Health Middle Aged Mixed Function Oxygenases - genetics Original Research Article Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacotherapy Polymorphism, Single Nucleotide Prothrombin - analysis Vitamin K Epoxide Reductases Warfarin - pharmacology Warfarin - therapeutic use
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