Liver Failure After Extended Hepatectomy in Mice Is Mediated by a p21-Dependent Barrier to Liver Regeneration

Background & Aims Extended liver resection leads to hepatic failure because of a small remnant liver volume. Excessive parenchymal damage has been proposed as the principal cause of this failure, but little is known about the contribution of a primary deficiency in liver regeneration. We develop...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2012-12, Vol.143 (6), p.1609-1619.e4
Hauptverfasser:	Lehmann, Kuno, Tschuor, Christoph, Rickenbacher, Andreas, Jang, Jae–Hwi, Oberkofler, Christian E, Tschopp, Oliver, Schultze, Simon M, Raptis, Dimitri A, Weber, Achim, Graf, Rolf, Humar, Bostjan, Clavien, Pierre–Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - physiology Cell Proliferation Cyclin-Dependent Kinase Inhibitor p21 - deficiency Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - physiology Disease Models, Animal Extended Hepatectomy Forkhead Box Protein M1 Forkhead Transcription Factors - physiology Gastroenterology and Hepatology Hepatectomy - adverse effects Liver - physiopathology Liver - surgery Liver Failure - etiology Liver Failure - physiopathology Liver Regeneration Liver Regeneration - physiology Liver Regeneration Failure Mice Mice, Inbred C57BL Mice, Knockout Organ Size - physiology Small-For-Size Syndrome
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