Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography
Abstract Objective Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholester...
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| creator | Tsubakio-Yamamoto, Kazumi Sugimoto, Taizo Nishida, Makoto Okano, Rieko Monden, Yasumasa Kitazume-Taneike, Rika Yamashita, Taiji Nakaoka, Hajime Kawase, Ryota Yuasa-Kawase, Miyako Inagaki, Miwako Nakatani, Kazuhiro Masuda, Daisaku Ohama, Tohru Matsuyama, Akifumi Nakagawa-Toyama, Yumiko Ishigami, Masato Komuro, Issei Yamashita, Shizuya |
| description | Abstract Objective Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance. |
| doi_str_mv | 10.1016/j.metabol.2012.05.011 |
| format | Article |
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We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2012.05.011</identifier><identifier>PMID: 22728065</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>6 Insulin sensitivity ; Adiponectin ; Adiponectin - blood ; Adult ; Aged ; Apolipoproteins - blood ; Asian Continental Ancestry Group - statistics & numerical data ; Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - metabolism ; Carotid Intima-Media Thickness ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cholesterol, VLDL - blood ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Endocrinology & Metabolism ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; High density lipoprotein ; HPLC ; Humans ; Insulin Resistance ; Japan ; Low density lipoprotein ; Male ; Middle Aged ; Multivariate Analysis ; Particle Size ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Metabolism, clinical and experimental, 2012-12, Vol.61 (12), p.1763-1770</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-cdaaaf8d29b29ca86a7d86d78fb00c21fb2a5496e49a4e72197cedd63ee4e6c23</citedby><cites>FETCH-LOGICAL-c483t-cdaaaf8d29b29ca86a7d86d78fb00c21fb2a5496e49a4e72197cedd63ee4e6c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.metabol.2012.05.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26673729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22728065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsubakio-Yamamoto, Kazumi</creatorcontrib><creatorcontrib>Sugimoto, Taizo</creatorcontrib><creatorcontrib>Nishida, Makoto</creatorcontrib><creatorcontrib>Okano, Rieko</creatorcontrib><creatorcontrib>Monden, Yasumasa</creatorcontrib><creatorcontrib>Kitazume-Taneike, Rika</creatorcontrib><creatorcontrib>Yamashita, Taiji</creatorcontrib><creatorcontrib>Nakaoka, Hajime</creatorcontrib><creatorcontrib>Kawase, Ryota</creatorcontrib><creatorcontrib>Yuasa-Kawase, Miyako</creatorcontrib><creatorcontrib>Inagaki, Miwako</creatorcontrib><creatorcontrib>Nakatani, Kazuhiro</creatorcontrib><creatorcontrib>Masuda, Daisaku</creatorcontrib><creatorcontrib>Ohama, Tohru</creatorcontrib><creatorcontrib>Matsuyama, Akifumi</creatorcontrib><creatorcontrib>Nakagawa-Toyama, Yumiko</creatorcontrib><creatorcontrib>Ishigami, Masato</creatorcontrib><creatorcontrib>Komuro, Issei</creatorcontrib><creatorcontrib>Yamashita, Shizuya</creatorcontrib><title>Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Abstract Objective Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.</description><subject>6 Insulin sensitivity</subject><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>Apolipoproteins - blood</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesterol, VLDL - blood</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinology & Metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>High density lipoprotein</subject><subject>HPLC</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Japan</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Particle Size</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhi0EotvCI4B8QeKSYDuJ41xAVSkUaSUOhbPl2JPGixOntlO03HhzvNoFJC6c5vL9M6NvBqEXlJSUUP5mV06QVO9dyQhlJWlKQukjtKFNxQrBCXmMNoQwXpC6a87QeYw7QkjbCv4UnTHWMkF4s0E_byGsE1bGLn4GneyMHTyAwzZi7UMApxIY_N2mEacRcLQ_APsB37zfYjUbvM11USFZ7SBiAwnCZOec6Pd4tHcjXiAMPkxq1oCdvV-twXoMflLJ3wW1jPtn6MmgXITnp3qBvn64_nJ1U2w_f_x0dbktdC2qVGijlBqEYV3POq0EV60R3LRi6AnRjA49U03dcag7VUPLaNdqMIZXADVwzaoL9PrYdwn-foWY5GSjBufUDH6NkuZELWpa04w2R1QHH2OAQS7BTirsJSXyYF_u5Mm-PNiXpJHZfs69PI1Y-wnMn9Rv3Rl4dQJU1MoNIWux8S_HeVu1rMvcuyMHWciDhSCjtpAVGhvykaTx9r-rvP2ng3Z2tnnoN9hD3Pk1zNm2pDLmjLw9vMrhUygjhHaiq34Bfl284w</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Tsubakio-Yamamoto, Kazumi</creator><creator>Sugimoto, Taizo</creator><creator>Nishida, Makoto</creator><creator>Okano, Rieko</creator><creator>Monden, Yasumasa</creator><creator>Kitazume-Taneike, Rika</creator><creator>Yamashita, Taiji</creator><creator>Nakaoka, Hajime</creator><creator>Kawase, Ryota</creator><creator>Yuasa-Kawase, Miyako</creator><creator>Inagaki, Miwako</creator><creator>Nakatani, Kazuhiro</creator><creator>Masuda, Daisaku</creator><creator>Ohama, Tohru</creator><creator>Matsuyama, Akifumi</creator><creator>Nakagawa-Toyama, Yumiko</creator><creator>Ishigami, Masato</creator><creator>Komuro, Issei</creator><creator>Yamashita, Shizuya</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography</title><author>Tsubakio-Yamamoto, Kazumi ; Sugimoto, Taizo ; Nishida, Makoto ; Okano, Rieko ; Monden, Yasumasa ; Kitazume-Taneike, Rika ; Yamashita, Taiji ; Nakaoka, Hajime ; Kawase, Ryota ; Yuasa-Kawase, Miyako ; Inagaki, Miwako ; Nakatani, Kazuhiro ; Masuda, Daisaku ; Ohama, Tohru ; Matsuyama, Akifumi ; Nakagawa-Toyama, Yumiko ; Ishigami, Masato ; Komuro, Issei ; Yamashita, Shizuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-cdaaaf8d29b29ca86a7d86d78fb00c21fb2a5496e49a4e72197cedd63ee4e6c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>6 Insulin sensitivity</topic><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Aged</topic><topic>Apolipoproteins - blood</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cholesterol, VLDL - blood</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinology & Metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>High density lipoprotein</topic><topic>HPLC</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Japan</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Particle Size</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsubakio-Yamamoto, Kazumi</creatorcontrib><creatorcontrib>Sugimoto, Taizo</creatorcontrib><creatorcontrib>Nishida, Makoto</creatorcontrib><creatorcontrib>Okano, Rieko</creatorcontrib><creatorcontrib>Monden, Yasumasa</creatorcontrib><creatorcontrib>Kitazume-Taneike, Rika</creatorcontrib><creatorcontrib>Yamashita, Taiji</creatorcontrib><creatorcontrib>Nakaoka, Hajime</creatorcontrib><creatorcontrib>Kawase, Ryota</creatorcontrib><creatorcontrib>Yuasa-Kawase, Miyako</creatorcontrib><creatorcontrib>Inagaki, Miwako</creatorcontrib><creatorcontrib>Nakatani, Kazuhiro</creatorcontrib><creatorcontrib>Masuda, Daisaku</creatorcontrib><creatorcontrib>Ohama, Tohru</creatorcontrib><creatorcontrib>Matsuyama, Akifumi</creatorcontrib><creatorcontrib>Nakagawa-Toyama, Yumiko</creatorcontrib><creatorcontrib>Ishigami, Masato</creatorcontrib><creatorcontrib>Komuro, Issei</creatorcontrib><creatorcontrib>Yamashita, Shizuya</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsubakio-Yamamoto, Kazumi</au><au>Sugimoto, Taizo</au><au>Nishida, Makoto</au><au>Okano, Rieko</au><au>Monden, Yasumasa</au><au>Kitazume-Taneike, Rika</au><au>Yamashita, Taiji</au><au>Nakaoka, Hajime</au><au>Kawase, Ryota</au><au>Yuasa-Kawase, Miyako</au><au>Inagaki, Miwako</au><au>Nakatani, Kazuhiro</au><au>Masuda, Daisaku</au><au>Ohama, Tohru</au><au>Matsuyama, Akifumi</au><au>Nakagawa-Toyama, Yumiko</au><au>Ishigami, Masato</au><au>Komuro, Issei</au><au>Yamashita, Shizuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>61</volume><issue>12</issue><spage>1763</spage><epage>1770</epage><pages>1763-1770</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Abstract Objective Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism. Material/method We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup. Results Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R. Conclusions APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22728065</pmid><doi>10.1016/j.metabol.2012.05.011</doi><tpages>8</tpages></addata></record> |
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| subjects | 6 Insulin sensitivity Adiponectin Adiponectin - blood Adult Aged Apolipoproteins - blood Asian Continental Ancestry Group - statistics & numerical data Biological and medical sciences Biomarkers - blood Blood Glucose - metabolism Carotid Intima-Media Thickness Cholesterol, HDL - blood Cholesterol, LDL - blood Cholesterol, VLDL - blood Chromatography, High Pressure Liquid Cross-Sectional Studies Endocrinology & Metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology High density lipoprotein HPLC Humans Insulin Resistance Japan Low density lipoprotein Male Middle Aged Multivariate Analysis Particle Size Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography |
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